Results 181 to 190 of about 632,185 (263)

Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA‐Charge Neutral Linkages for Enhanced Splice‐Switching Antisense Oligonucleotides

Angewandte Chemie, EarlyView.
Splice‐switching oligonucleotides are used to treat severe genetic conditions including Duchenne Muscular Dystrophy, but new chemistries are urgently required to improve their efficacy. In this work locked nucleic acid (LNA) is coupled to different charge neutral DNA backbones which are studied by structural, thermodynamic, and biological methods.
Alice Kennett, Lillian Lie, Martin Flerin, Belma Zengin Kurt, Ysobel R. Baker, Alyssa C. Hill, Abinaya Ramesh, Matthew J.A. Wood, Debashis Dhara, Afaf H. El‐Sagheer, Fernanda Duarte, Tom Brown   +11 more
wiley   +2 more sources

Reporting and representation of race and ethnicity data in phase III clinical trials for hematological malignancies. [PDF]

Future Sci OA
Wang T, Banerjee A, Gifkins D.
europepmc   +1 more source

Volumetric MRI Comparing Longitudinal Change in MOGAD to NMOSD, MS and Healthy Controls, and Disability Associations

Annals of Neurology, EarlyView.
Objectives To examine volumetric magnetic resonance imaging (vMRI) in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), compared to multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and healthy controls (HC). Methods Standardized vMRI in MOGAD were compared to age, sex, and disease duration matched MS (5:1),
Amy Kunchok, Moein Amin, Tatchaporn Ongphichetmetha, Mengke Du, Robert Bermel, Tucker Harvey, Justin R. Abbatemarco, Stephen E. Jones, Jeffrey A. Cohen, Daniel Ontaneda, Kunio Nakamura   +10 more
wiley   +1 more source

De Novo Design of High‐Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor

Angewandte Chemie, EarlyView.
Hybrid physics and deep‐learning enabled design methods identified miniprotein binders to Flpp3 (Francisella‐like lipoprotein), a key virulence factor from Francisella tularensis. Multiple candidates with nanomolar to picomolar binding affinities were obtained using yeast surface display screening and further experimental optimization.
Gizem Gokce‐Alpkilic, Buwei Huang, Andi Liu, Lieselotte S.M. Kreuk, Yaxi Wang, Victor Adebomi, Yensi Flores Bueso, Asim K. Bera, Alex Kang, Stacey R. Gerben, Stephen Rettie, Dionne K. Vafeados, Nicole Roullier, Inna Goreshnik, Xinting Li, David Baker, Joshua J. Woodward, Joseph D. Mougous, Gaurav Bhardwaj   +18 more
wiley   +2 more sources

The Translational Research Program in Cancer Differences across Populations. [PDF]

Cancer Epidemiol Biomarkers Prev
Figueiredo JC, Redwood D, Li L, Donato E, Fort D, Fox EE, Grady WM, Green H, Harrison TA, Haupt C, Hsu L, Hullar MAJ, Huyghe JR, Johnson W, Koehne AL, LaBrie SD, Lakey MA, Lin M, Loroña NC, Maresh GA, Matrana M, Mizrahi JD, Nash SH, Nguyen NT, Paruch JL, Phipps AI, Qu C, Randolph TW, Romo S, Thomas CE, Thomas S, Tiesinga J, Whitlow C, Yeung CCS, Yin H, Zibilich CM, Li CI, Thomas TK, Peters U.   +38 more
europepmc   +1 more source

Papers from the Harriman Alaska Expedition XVIII. Entomological Results (12): Coleoptera. Coleoptera of the Expedition

, 1900
Eugene Amandus Schwarz
openalex   +2 more sources

Targeted Proteomics upon Treatment with Tofersen Identifies Novel Response Markers for Superoxide Dismutase 1‐Linked Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke, Karthik Baskar, Franziska Bachhuber, Maximilian Wiesenfarth, Johannes Dorst, Joachim Schuster, Florian Schöberl, Peter Reilich, Martin Regensburger, Alexander German, René Günther, Maximilian Vidovic, Susanne Petri, Thomas Meyer, Tim Hagenacker, Julian Grosskreutz, Ute Weyen, Patrick Weydt, Thomas Haarmeier, Paul Lingor, Joachim Wolf, Andreas Hermann, Johannes Prudlo, Kornelia Günther, Antje Knehr, Zeynep Elmas, Zeljko Uzelac, Simon Witzel, Wolfgang Philipp Ruf, Axel Freischmidt, Ritchie Ho, Albert C. Ludolph, Jochen H. Weishaupt, Hayrettin Tumani, Patrick Oeckl, David Brenner, Alberto Catanese   +36 more
wiley   +1 more source

Organocatalyzed Atom Transfer Radical Polymerization (O‐ATRP) Using a Super‐Reducing Photoredox Catalyst

Angewandte Chemie, EarlyView.
A super‐reducing organic photocatalyst expands the scope of O‐ATRP to challenging initiators and monomers. The system enables controlled polymerizations with air tolerance, temporal regulation, and grafting‐from strategies, highlighting the transformative potential of super‐reducing PCs in reversible‐deactivation radical polymerization.
Yucheng Zhao, Brandon S. Portela, Alexander R. Green, Anna M. Wolff, Xin Liu, Katherine O. Puffer, Arindam Sau, Niels H. Damrauer, Robert S. Paton, Garret M. Miyake   +9 more
wiley   +2 more sources

Amplifying Cultural Values with Collaborative Photo-Elicitation: Strengths-Focused Co-Design with Alaska Native People. [PDF]

DIS (Des Interact Syst Conf)
Dirks LG, Belarde-Lewis M, Pratt W.
europepmc   +1 more source

Dispersion of First Sound in a Weakly Interacting Ultracold Fermi Liquid

Annalen der Physik, EarlyView.
 The weak‐interaction, low‐temperature region of the phase diagram of a Fermi gas the so‐called Fermi liquid regime, which has been somewhat overlooked in ultracold gases‐is investigated. Precise and measurable predictions are presented for the viscosity and dispersion of first sound to leading order in the scattering length.
Thomas Repplinger, Songtao Huang, Yunpeng Ji, Nir Navon, Hadrien Kurkjian   +4 more
wiley   +1 more source