Results 171 to 180 of about 609,297 (304)

T cell plasticity in systemic lupus erythematosus revealed by large‐scale T cell receptor repertoire and transcriptome studies

Arthritis &Rheumatology, Accepted Article.
Objective We aimed to characterize CD4+ T cell plasticity in human SLE by leveraging TCR repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity.
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source

Building new hydrography and virtual watersheds to conserve freshwater fisheries. [PDF]

Sci Rep
Benda L, Miller D, Leppi JC, Romey B, Andras K.   +4 more
europepmc   +1 more source

NeuroTwister: Gamified learning to teach cross‐sectional neuroanatomy to medical students

Anatomical Sciences Education, EarlyView.
Abstract Neuroscience is a required course in many health professions curricula, but with it often comes neurophobia, the fear or difficulty that students experience when attempting to learn neuroscience. Traditional teaching methods in neuroanatomy may contribute to cognitive overload and stress, reinforcing the notion that neuroanatomy is ...
Cameron B. Jeter, Kiley M. Gagain, Shannon N. Curran, Natalia S. Rozas   +3 more
wiley   +1 more source

On open access, data mining and plant conservation in the Circumpolar North with an online data example of the Herbarium, University of Alaska Museum of the North

Arctic Science, 2018
Falk Huettmann, Stefanie M. Ickert-Bond
doaj   +1 more source

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Tradeoffs Among Predator Control, Moose Harvests, and Trophy Antlers: Principles Pertinent to Managing Alaska's Wildlife. [PDF]

Animals (Basel)
Bowyer RT, Miller SD, Person DK.
europepmc   +1 more source

Main factors associated with variability in the assessment of the objective response rate. A re‐analysis of the PHEREXA phase 3 clinical trial

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Local investigators (LIs) overestimate the objective response rate (ORR) in comparison to Blinded Independent Central Reviewers (BICR) in oncology. In this study, we re‐analysed data obtained in the PHEREXA trial (NCT01026142) with the following aims: i) to confirm at the single‐patient level the discrepancy observed by analysing ...
Gennaro Daniele, Tommaso Giovagnoli, Pierluigi Navarra, Cinzia Dello Russo   +3 more
wiley   +1 more source

Scoping Review of the Environmental and Human Health Effects of Rural Alaska Landfills. [PDF]

Int J Environ Res Public Health
Chaney C, Moore-Nall A, Albert C, Beebe C, Bierwagen B, Davis M, Demoski A, Ip A, Jordan P, Lee SS, Mutter E, Oliver L, Rallo N, Schofield K, Seetot J, Shugak A, Tom A, Turner M, Zender L.   +18 more
europepmc   +1 more source

The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The quantitative effect of several inhibitory drugs on the development of adverse drug reactions (ADRs) is currently difficult to estimate. Our aim was to identify metabolic pathways, which, when inhibited, increase the risk for certain ADRs, and to use this system to consider comedication at individual level. Methods Data of a prospective
Judith Berres, Justyna Wozniak, Hannah Fölsch, Anja Knueppel‐Ruppert, Verena Graeff, Andrea Kriegisch‐Stumpf, Harald Dormann, Julia C. Stingl, Katja S. Just   +8 more
wiley   +1 more source

Climate impacts from North American boreal forest fires. [PDF]

Nat Geosci
van Gerrevink MJ, Veraverbeke S, Cooperdock S, Potter S, Zhong Q, Moubarak M, Virkkala AM, Goetz SJ, Mack MC, Randerson JT, Schutgens N, Turetsky MR, van der Werf GR, Rogers BM.   +13 more
europepmc   +1 more source