British Journal of Clinical Pharmacology, EarlyView.Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert +6 more
wiley +1 more source
Region- and season-specific exposure to lead in a common North American songbird. [PDF]
EcotoxicologyOhrberg ML +7 more
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Purpose To quantify how often creatine kinase (CK) is measured after newly elevated aminotransferases in statin users, and whether absent CK data are associated with gastroenterology (GI) referrals. Methods Retrospective chart review of adult outpatients on statins with a first alanine/aspartate aminotransferase (ALT/AST) elevation during a 5 ...
Faris Shweikeh +5 more
wiley +1 more source
Prevalence and Clinical Characteristics of Systemic Sclerosis in Alaska Native and American Indian Peoples in Alaska. [PDF]
ACR Open RheumatolMehta VR +5 more
europepmc +1 more source
Phenazine‐Based Synthetic Biology to Signal Between Cells and Electrodes
Biotechnology and Bioengineering, EarlyView.ABSTRACT Bioelectronic systems that enable seamless communication between electronic devices and living systems represent a transformative frontier in biotechnology. Among available methodologies, redox based signaling offers unique advantages due to its ubiquity in biology and compatibility with standard electrochemical equipment, expanding on ...
Eric VanArsdale +8 more
wiley +1 more source
Point-of-Care Hepatitis C Testing in a Tribal Setting.
JAMA Netw OpenMera J +5 more
europepmc +1 more source
Are you worried someone in your household is at risk of suicide? Piloting ways to acceptably and feasibly increase safe firearm storage in rural Alaska. [PDF]
Inj PrevWexler L +11 more
europepmc +1 more source
The influence of rivers on seabird foraging ecology
Biological Reviews, EarlyView.ABSTRACT Rivers act as vital arteries to the world's oceans, delivering fresh water and nutrients that sustain marine ecosystems. Globally, river flow increasingly is being altered by climate change and anthropogenic pressures; yet the significance of rivers to predatory marine species, such as seabirds, and the extent to which river‐related changes ...
Julia B. Morais +2 more
wiley +1 more source
Fragment-Based Online OzESI-MS, NMR, and Computational DP4+/DFT Approaches to the Characterization of the Putative Biosynthetic Lipid Precursor of Atkamine from Alaskan <i>Latrunculia</i> Sponges. [PDF]
ACS OmegaBenjamin MM +11 more
europepmc +1 more source
Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife
Biological Reviews, EarlyView.ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief +4 more
wiley +1 more source