Results 71 to 80 of about 87,895 (325)

GABP Promotes Mesangial Cell Proliferation and Renal Fibrosis Through GLI1 in Diabetic Nephropathy

Advanced Science, EarlyView.
GABP is found to promote mesangial cell proliferation and ECM deposition through GLI1, while inhibiting GABP or GLI1 prevents the progression of DN by reducing ECM and fibrosis. The research results indicate that a potential therapeutic approach based on inhibiting mesangial cell proliferation and ECM accumulation can effectively treat DN, while GABP ...
Lei Du, Sijie Liu, Yinfei Lu, Dongxue Ren, Xiujuan Yu, Yue Hu, Tingting Yang, Qun Yang, Jingxian Ming, Jiawei Zhang, Xiaoxing Yin, Qian Lu   +11 more
wiley   +1 more source

Association of domain-specific physical activity with albuminuria among prediabetes and diabetes: a large cross-sectional study

Journal of Translational Medicine
Background Albuminuria, the presence of excess of protein in urine, is a well-known risk factor for early kidney damage among diabetic/prediabetic patients. There is a complex interaction between physical activity (PA) and albuminuria.
Bingquan Xiong, Yufan Wang, Juan He, Lisha Wang, Rui He, Min Zhu, Jiaxing Wang, Yingrui Li, Bin Liu, Kaihu Xiao, Qiang She   +10 more
doaj   +1 more source

Cardiovascular disease biomarkers are associated with declining renal function in type 2 diabetes [PDF]

, 2017
Aims/hypothesis: We investigated whether biochemical cardiovascular risk factors and/or markers of subclinical cardiovascular disease were associated with the development of reduced renal function in people with type 2 diabetes.
Conway, Bryan R., Jenks, Sara J., McLachlan, Stela, Price, Jackie F., Sattar, Naveed, Strachan, Mark W.J., Teoh, Wei Leng, Webb, David J., Welsh, Paul, Williamson, Rachel M.   +9 more
core   +2 more sources

Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING‐Mediated Glycolysis

Advanced Science, EarlyView.
Pyruvate carboxylase (PC), as a catalytic enzyme located within the mitochondria, plays an important role in kidney fibrosis. PC deficiency reduces its interaction with sulfide:quinone oxidoreductase (SQOR), increasing the ubiquitination and degradation of SQOR.
Hao Huang, Yuanyuan Han, Yan Zhang, Jianhua Zeng, Xin He, Jiawei Cheng, Songkai Wang, Yiwei Xiong, Hongling Yin, Qiongjing Yuan, Ling Huang, Yanyun Xie, Jie Meng, Lijian Tao, Zhangzhe Peng   +14 more
wiley   +1 more source

Albuminuria in patients with chronic obstructive pulmonary disease: a cross-sectional study in an African patient cohort

BMC Pulmonary Medicine, 2018
Background Cardiovascular disease (CVD) is remarkably frequent in patients with chronic obstructive pulmonary disease (COPD). Albuminuria is a marker of vascular endothelial dysfunction and predictor of CVD events.
Festo K. Shayo, Janet Lutale
doaj   +1 more source

Association between glycemic control and albuminuria among Peruvian adults with diabetes mellitus 2: a cross-sectional analytical study

São Paulo Medical Journal, 2022
BACKGROUND: Albuminuria is a risk factor for microvascular and macrovascular complications in the diabetic population. However, few studies have correlated poor glycemic control and albuminuria prevalence in Hispanic populations.
Lucero Del Carmen Collazos-Huamán, Camila Guerreros-Espino, Percy Herrera-Añazco, Vicente Aleixandre Benites-Zapata   +3 more
doaj   +1 more source

Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy in TYpe 2 diabetic patients with normoalbuminuria (PRIORITY): essential study design and rationale of a randomised clinical multicentre trial [PDF]

, 2016
Introduction: Diabetes mellitus affects 9% of the European population and accounts for 15% of healthcare expenditure, in particular, due to excess costs related to complications.
Beige, Joachim, Currie, Gemma, Delles, Christian, Lindhardt, Morten, Mischak, Harald, Navis, Gerjan, Noutsou, Marina, Ortiz, Alberto, Persson, Frederik, Pontillo, Claudia, Rossing, Peter, Ruggenenti, Piero Luigi, Rychlik, Ivan, Spasovski, Goce, von der Leyen, Heiko   +14 more
core   +4 more sources

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

The compound heterozygous mutations of c.607G>a and c.657delC in the FAH gene are associated with renal damage with hereditary tyrosinemia type 1 (HT1)

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
This study demonstrated the novel compound heterozygous mutations (NM_000137: c.657delC (p.K220Rfs*12) and NM_000137: c.607G>A(p.A203T)) in FAH gene in a patient were responsible for HT1. We showed these FAH mutations were inherited in an autosomal recessive manner and resulted in abnormal FAH protein expression and dysfunction, leading to ...
Huan Chi, Chun Gan, Yaru Jiang, Dan Chen, Jiawen Qiu, Qing Yang, Yaxi Chen, Mo Wang, Haiping Yang, Wei Jiang, Qiu Li   +10 more
wiley   +1 more source

The ratio of AGE to sRAGE independently associated with albuminuria in hypertensive patients

BMC Endocrine Disorders, 2018
Background Soluble receptor for advanced glycation end-products (sRAGE) and advanced glycation end-products (AGE) have been associated with risks of cardiovascular disease.
Kuang-Hsing Chiang, Jaw-Wen Chen, Shao-Sung Huang, Hsin-Bang Leu, Shing-Jong Lin, Po-Hsun Huang   +5 more
doaj   +1 more source