Results 71 to 80 of about 125,121 (369)

Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial. [PDF]

, 2015
Apolipoprotein L1 gene (APOL1) G1 and G2 coding variants are strongly associated with chronic kidney disease (CKD) in African Americans (AAs). Here APOL1 association was tested with baseline estimated glomerular filtration rate (eGFR), urine albumin ...
Bild, Diane E, Divers, Jasmin, Freedman, Barry I, Hawfield, Amret T, Kaysen, George A, Kimmel, Paul L, Langefeld, Carl D, Pajewski, Nicholas M, Raj, Dominic S, Reboussin, David M, Ricardo, Ana C, Rocco, Michael V, Sedor, John R, Systolic Blood Pressure Intervention Trial (SPRINT), Wright, Jackson T   +14 more
core   +1 more source

Effect of Canagliflozin on Renal and Cardiovascular Outcomes across Different Levels of Albuminuria: Data from the CANVAS Program.

Journal of the American Society of Nephrology, 2019
BACKGROUND If SGLT2 inhibitors protect the kidneys by reducing albuminuria as hypothesized, people with type 2 diabetes mellitus (T2DM) with higher albuminuria should benefit more. METHODS We conducted a post-hoc analysis of data from the CANagliflozin
B. Neuen, T. Ohkuma, B. Neal, D. Matthews, D. de Zeeuw, K. Mahaffey, G. Fulcher, Qiang Li, M. Jardine, Richard Oh, H. Heerspink, V. Perkovic   +11 more
semanticscholar   +1 more source

Electrochemical Biosensor for Rapid Detection of Acute Rejection in Kidney Transplants

Advanced Healthcare Materials, EarlyView.
A low‐cost, rapid electrochemical immunosensor coated with a novel antifouling nanocomposite enables single‐step, dual‐biomarker profiling directly from unprocessed urine. Application in a clinical study shows accurate discrimination of acute rejection in kidney transplants from other acute kidney injuries via machine learning.
Rohit Gupta, Nikolaos Salaris, Ashish Kalkal, Fernando Yuen Chang, Maryam Javed, Azhar Ali Khan, Priya Mandal, Stavroula Balabani, Reza Motallebzadeh, Manish K. Tiwari   +9 more
wiley   +1 more source

Increased prevalence of albuminuria in HIV-infected adults with diabetes. [PDF]

PLoS ONE, 2011
HIV and type 2 diabetes are known risk factors for albuminuria, but no previous reports have characterized albuminuria in HIV-infected patients with diabetes.We performed a cross-sectional study including 73 HIV-infected adults with type 2 diabetes, 82 ...
Peter S Kim, Christian Woods, Lauren Dutcher, Patrick Georgoff, Alice Rosenberg, Jo Ann M Mican, Jeffrey B Kopp, Margo A Smith, Colleen Hadigan   +8 more
doaj   +1 more source

Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use Among Hypertensive US Adults With Albuminuria

HYPERTENSION, 2020
Supplemental Digital Content is available in the text. Since 2003, US hypertension guidelines have recommended ACE (angiotensin-converting enzyme) inhibitors or ARBs (angiotensin receptor blockers) as first-line antihypertensive therapy in the presence ...
Chi D. Chu, N. Powe, C. McCulloch, Tanushree Banerjee, D. Crews, R. Saran, J. Bragg-Gresham, H. Morgenstern, Meda E. Pavkov, S. Saydah, D. Tuot   +10 more
semanticscholar   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Prevalencia de Micro albuminuria en pacientes hipertensos no diabéticos

Revista de la Facultad de Medicina, 2017
Introducción: Se ha demostrado que la presencia de micro albuminuria puede reflejar el desarrollo de enfermedad cardiovascular en pacientes con diabetes mellitus, este fenómeno también se ha observado en pacientes no diabéticos.
Sofia Roldán, Clara Chang
doaj   +1 more source

The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan

Scientific Reports, 2021
Activin A, a cytokine belonging to the transforming growth factor-β family, has been shown to play pivotal roles in tissue remodeling after renal injury and is present in elevated levels in diabetic patients.
Shih-Chen Chang, Chien-Yi Hsu, Li-Kuo Liu, Ya-Wen Lu, Yi-Lin Tsai, Ruey-Hsing Chou, Po-Hsun Huang, Liang-Kung Chen, Shing-Jong Lin   +8 more
doaj   +1 more source

Albuminuria and Serum Tumor Necrosis Factor Receptor Levels in Patients with Type 2 Diabetes on SGLT2 Inhibitors: A Prospective Study [PDF]

, 2023
Toshiki Otoda, Akiko Sekine, Ryoko Uemoto, Seijiro Tsuji, Tomoyo Hara, Motoyuki Tamaki, Tomoyuki Yuasa, Toshiaki Tamaki, Munehide Matsuhisa, Ken‐ichi Aihara   +9 more
openalex   +1 more source

TREM2 Drives Neutrophil Extracellular Traps‐Induced Dendritic Cell Maturation and Contributes to Lupus Progression

Advanced Science, EarlyView.
TREM2 recognizes NETs‐derived MPO to promote DC maturation and antigen presentation, thereby exacerbating the autoimmune response in SLE. Mechanistically, TREM2 activation triggers the DAP12/SYK/ERK cascade and enhances NETs internalization by DCs, which in turn activates the cGAS/STING signaling pathway.
Jingxian Shu, Jiabi Liang, Linda Zeng, Shuping Zhong, Xueling Fang, Yating Xu, Yongjian Wu, Xi Huang   +7 more
wiley   +1 more source