Results 41 to 50 of about 17,343 (263)
Reducing Albuterol Use in Children With Bronchiolitis
Pediatrics, 2018 Implementation of a clinical pathway reduced the use of albuterol among hospitalized infants with bronchiolitis. OBJECTIVES: In 2014, the American Academy of Pediatrics published bronchiolitis guidelines recommending against the use of bronchodilators ...
M. Dunn +7 more
semanticscholar +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Although attractive for relevance to real‐world scenarios, real‐world data (RWD) is typically used for drug repurposing and not therapeutic target discovery. Repurposing studies have identified few effective options in neurological diseases such as the rare disease, amyotrophic lateral sclerosis (ALS), which has no disease‐modifying treatments ...
Mohammadali Alidoost +9 more
wiley +1 more source
Medication Utilization Among Children With Sickle Cell Disease in the United States
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background and Objective The medication management of children with sickle cell disease (SCD), especially since the release of the 2014 National Heart, Lung, and Blood Institute (NHLBI) SCD treatment guidelines, is not well described in the published literature.
Abiodun John Ologunowa +5 more
wiley +1 more source
Hospital Pediatrics, 2018 OBJECTIVES To identify associations between use of ipratropium and/or intravenous magnesium and outcomes of children hospitalized with acute asthma exacerbations and treated with continuous albuterol.
S. Shein +12 more
semanticscholar +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to the difficulty of taking samples from different regions of the human lung, often only systemic ...
Rui Zhu +12 more
wiley +1 more source
Academic Emergency Medicine, EarlyView.Abstract Background Asthma is the most common chronic illness of childhood and a leading cause of hospitalization and health care costs for children. Intravenous magnesium sulfate (IVMg) may help severely ill children avoid hospitalization when added to standard treatment in an emergency department (ED), but this has not been adequately evaluated in a ...
Michael D. Johnson +10 more
wiley +1 more source
Oral Immunotherapy in Peanut‐Allergic Adults Using Real‐World Materials
Allergy, EarlyView.In 21 adults initiated on peanut oral immunotherapy (OIT), 67% tolerated at least 1000 mg on exit DBPCFC. Decreases in SPT size and increases in peanut‐ and Ara h 2‐specific IgG occurred in OIT participants but not in mechanistic controls (n = 9). Improvements were seen in FAQLQ‐AF and food neophobia scores.
Hannah Hunter +10 more
wiley +1 more source
Allergy, EarlyView.ABSTRACT Introduction The 2019 Global Initiative for Asthma (GINA) report no longer recommended short‐acting beta‐agonists (SABA) monotherapy due to associated complications and a lack of anti‐inflammatory properties. This systematic review and meta‐analysis aimed to evaluate adverse outcomes associated with SABA overuse in patients with asthma ...
Chia‐Ling Tsao +6 more
wiley +1 more source
Efficacy of Inhaled Levalbuterol Compared to Albuterol in Horses with Recurrent Airway Obstruction
Journal of Veterinary Internal Medicine, 2016 Background The (R)‐enantiomer of racemic albuterol (levalbuterol) has bronchodilatory properties whereas the (S)‐enantiomer causes adverse effects in human airways, animal models, and isolated equine bronchi.
M. G. Arroyo +4 more
semanticscholar +1 more source
Dupilumab Efficacy and Safety in Patients With Persistent Asthma: Asia–Pacific Region
Clinical &Experimental Allergy, EarlyView.Asthma prevalence is increasing in the Asia–Pacific region, and this population is frequently underrepresented in phase 3 clinical studies. We demonstrate Dupilumab's efficacy and safety among patients with uncontrolled moderate‐to‐severe type 2 asthma.
Qingling Zhang +13 more
wiley +1 more source