Results 81 to 90 of about 10,726 (212)

Beta2‐adrenergic agonist salbutamol exhibits enantioselective disposition in skeletal muscle of lean young men following oral administration

Drug Testing and Analysis, Volume 17, Issue 6, Page 842-849, June 2025.
Oral administration of salbutamol shows enantioselective disposition in human skeletal muscle, favoring the (S)‐enantiomer with higher relative partitioning of the pharmacologically active (R)‐enantiomer in muscle. This is concerning from an anti‐doping point of view because the anabolic properties demonstrated for salbutamol can potentially be ...
Morten Hostrup, Glenn A. Jacobson, Kasper Eibye, Christian K. Narkowicz, David S. Nichols, Søren Jessen   +5 more
wiley   +1 more source

Excessive gas exchange impairment during exercise in a subject with a history of bronchopulmonary dysplasia and high altitude pulmonary edema [PDF]

, 2007
A 27-year-old male subject (V(O2 max)), 92% predicted) with a history of bronchopulmonary dysplasia (BPD) and a clinically documented case of high altitude pulmonary edema (HAPE) was examined at rest and during exercise.
Andrew T. Lovering, Garg M., Hans C. Haverkamp, John S. Hokanson, Knudson R.J., Lee M. Romer, Marlowe W. Eldridge   +6 more
core   +1 more source

Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations

The Journal of Clinical Pharmacology, Volume 65, Issue 6, Page 665-674, June 2025.
Abstract Pediatric asthma exacerbations represent a significant cause of emergency department use and hospitalizations. Despite available treatment options, many children's exacerbations are refractory to standard therapies and require adjunct treatments.
Joseph E. Rower, Michael D. Johnson, Joseph J. Zorc, Bashar Shihabuddin, Mengtao Dai, Bradley J. Barney, Yaron Finkelstein   +6 more
wiley   +1 more source

Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled TMEM16A Potentiator GDC‐6988

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 6, Page 1087-1097, June 2025.
ABSTRACT The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to the difficulty of taking samples from different regions of the human lung, often only systemic ...
Rui Zhu, Ian Sorrell, Fang Ma, Miaoran Ning, Yoen‐Ju Son, Gaohong She, Tom De Bruyn, Joshua Galanter, Nastya Kassir, Ryan Owen, Masoud Jamei, Iain Gardner, Yuan Chen   +12 more
wiley   +1 more source

Albuterol as an adjunctive treatment to enzyme replacement therapy in infantile-onset Pompe disease

Molecular Genetics and Metabolism Reports, 2017
Background: Early initiation of enzyme replacement therapy (ERT) with recombinant human acid alpha-glucosidase is an effective treatment for patients with infantile-onset Pompe disease (IOPD) but cannot prevent a slow progression of myopathy.
Yin-Hsiu Chien, Wuh-Liang Hwu, Ni-Chung Lee, Fuu-Jen Tsai, Dwight D. Koeberl, Wen-Hui Tsai, Pao-Chin Chiu, Chaw-Liang Chang   +7 more
doaj   +1 more source

Comparison of albuterol sulphate and base dry powder particulate deposition using the Calu-3 lung epithelial model [PDF]

, 2011
To effectively predict the fate of formulated inhalation compounds delivered to the lung, a model of the airway epithelium should reflect drug permeability and transport characteristics in vivo.
Bebawy, M, Haghi, M, Traini, D, Young, P
core  

Pediatric asthma severity score is associated with critical care interventions [PDF]

, 2017
AIM: To determine if a standardized asthma severity scoring system (PASS) was associated with the time spent on continuous albuterol and length of stay in the pediatric intensive care unit (PICU).
Krupp, Nadia, Maue, Danielle K., Rowan, Courtney M.   +2 more
core   +1 more source

Intentional salbutamol poisoning: report of two siblings and review of the literature

Saudi Journal of Emergency Medicine
Background: About 65% of poisoning cases are related to children and of these, more than half of the patients are 5-year-old or less. While non-accidental poisoning is rare.
Dana Altamimi, Mohammed AlDeeb, Majid Al Eissa   +2 more
doaj   +1 more source

Effects of flow rate on transnasal pulmonary aerosol delivery of bronchodilators via high-flow nasal cannula for patients with COPD and asthma: protocol for a randomised controlled trial

BMJ Open, 2019
IntroductionBoth in vitro and in vivo radiolabelled studies on nebulisation via high-flow nasal cannula showed that inhaled dose decreases as the administered gas flow increases. In our previous in vitro study, we investigated the effects of the ratio of
Jian Luo, Yibing Chen, Lixing Xie, James B Fink   +3 more
doaj   +1 more source

Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma [PDF]

, 2011
Asthma patients who continue to experience symptoms despite being on regular inhaled corticosteroids (ICS) represent a management challenge. Long-acting beta2-agonists (LABA) or anti-leukotrienes (LTRA) are two treatment options that could be considered ...
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core   +1 more source