Results 1 to 10 of about 57,781 (271)

Pharmacoepidemiology of Drug Exposure in Intubated and Non-Intubated Preterm Infants With Severe Bronchopulmonary Dysplasia

Frontiers in Pharmacology, 2021
Background: Infants with severe bronchopulmonary dysplasia (BPD) are commonly treated with off-label drugs due to lack of approved therapies. To prioritize drugs for rigorous efficacy and safety testing, it is important to describe exposure patterns in ...
T. Lewis, W. Truog, L. Nelin, N. Napolitano, R. L. McKinney, and on behalf of The BPD Collaborative   +5 more
doaj   +1 more source

Cucumis sativus L. Seeds Ameliorate Muscular Spasm-Induced Gastrointestinal and Respiratory Disorders by Simultaneously Inhibiting Calcium Mediated Signaling Pathway

Pharmaceuticals, 2021
Cucumis sativus L. is globally cultivated as an edible vegetable. Besides its nutritional benefits, it is used in traditional medicines against various ailments. The current study was designed to elucidate the multi-target mechanisms of a C.
Muqeet Wahid, Fatima Saqib, Hanadi Talal Ahmedah, Claudia Mihaela Gavris, Vincenzo De Feo, Mircea Hogea, Marius Moga, Radu Chicea   +7 more
doaj   +1 more source

Managing bronchiolitis in pediatric patients: Current evidence

Indian Journal of Respiratory Care, 2022
Background: Acute bronchiolitis is an inflammatory process affecting small airways. Although most cases are self-limiting, it is still one of the most common causes of hospitalization below 24 months of age. Treatment is mainly supportive. The purpose of
Subhranshu Sekhar Dhal, Hiremath Sagar
doaj   +1 more source

Possible Mechanisms Underlying the Antispasmodic, Bronchodilator, and Antidiarrheal Activities of Polarity–Based Extracts of Cucumis sativus L. Seeds in In Silico, In Vitro, and In Vivo Studies

Pharmaceuticals, 2022
Apart from the nutritional value, Cucumis sativus L. has also been used in the traditional medicine of Iran, Pakistan, and India. Its seeds are used by herbalists to treat gastrointestinal, respiratory, and urinary problems.
Muqeet Wahid, Fatima Saqib, Saeed Akhtar, Anam Ali, Polrat Wilairatana, Mohammad S. Mubarak   +5 more
doaj   +1 more source

Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity

Frontiers in Pharmacology, 2020
Local anesthetics (LAs), such as lidocaine and mexiletine, inhibit bronchoconstriction in asthmatics, but adverse effects limit their use for this specific clinical application.
Katharinne Ingrid Moraes Carvalho, Diego de Sá Coutinho, Humberto Cavalcante Joca, Artur Santos Miranda, Jader dos Santos Cruz, Emerson Teixeira Silva, Marcus Vinícius Nora Souza, Robson Xavier Faria, Patricia Machado Rodrigues e Silva, Jorge Carlos Santos Costa, Marco Aurélio Martins   +10 more
doaj   +1 more source

Pharmacological Validation for the Folklore Use of Ipomoea nil against Asthma: In Vivo and In Vitro Evaluation

Molecules, 2022
Oxidative stress is the key factor that strengthens free radical generation which stimulates lung inflammation. The aim was to explore antioxidant, bronchodilatory along with anti-asthmatic potential of folkloric plants and the aqueous methanolic crude ...
Taha Alqahtani, Sajida Parveen, Yahia Alghazwani, Hanan M. Alharbi, Reem M. Gahtani, Nadia Hussain, Kashif ur Rehman, Musaddique Hussain   +7 more
doaj   +1 more source

Nebuliser therapy in the intensive care unit [PDF]

, 1997
The relationship between identity, lived experience, sexual practices and the language through which these are conveyed has been widely debated in sexuality literature.
A Brah, A Ka Tat Tsang, A Konitzer-Smirnov, A Rotkirch, A Temkina, BJ Baer, C Farquhar, C Ramazanoglu, CM Hann, D Altman, D Cameron, D Healey, D Kulick, DP Schluter, E Lewin, E Omel’chenko, E Omel’chenko, EK Sedgwick, EW Said, F Fukuyama, F Stella, F Stella, I Brade, IB Neumann, IS Kon, J Binnie, J Butler, J Butler, J Weeks, JD Brewer, JK Puar, K Plummer, K Sarajeva, K Weston, L Duggan, L Engelstein, L Essig, L Garber, L McCall, L Wolff, M Besemeres, M Foucault, M Müller, M Nemtsev, M Vicinus, MFI Manalansan, N Duncan, N Nartova, N Nartova, N Nartova, NA Naples, R Bleys, S Ashwin, S Seidman, SI Golod, T Boellstorff, T Boellstorff, V Kolossov, W Leap, Y Taylor   +59 more
core   +2 more sources

Triple Therapy of Fluticasone Furoate, Umeclidinium, Vilanterol- A Compelling Choice in Severe Chronic Obstructive Pulmonary Disease [PDF]

Journal of Clinical and Diagnostic Research, 2021
Trelegy Ellipta (GlaxoSmithKlineTM) is the first single inhaler triple combination therapy comprising of umeclidinium, vilanterol and fluticasone approved by the United States Food and Drug Administration (US FDA) for patients with severe COPD in 2019.
B Jagan Nathan, Melina I Sahay, AK Gautham, DK Sriram, Melvin George   +4 more
doaj   +1 more source

Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency. [PDF]

, 2015
Adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID) is characterized by impaired T-, B- and NK-cell function. Affected children, in addition to early onset of infections, manifest non-immunologic symptoms including pulmonary ...
Candotti, Fabio, Hershfield, Michael S, Kohn, Donald B, Komarow, Hirsh D, Metcalfe, Dean D, Sokolic, Robert, Young, Michael   +6 more
core   +2 more sources

Bronchodilatory and B-adrenergic effects of methanolic and aqueous extracts of Althaea root on isolated tracheobronchial smooth rat muscle

Advanced Biomedical Research, 2015
Background: The smooth muscle contractions of the tracheobronchial airways are mediated through the balance of adrenergic, cholinergic and peptidergic nervous mechanisms.
Behrang Alani, Mohammad Zare, Mahdi Noureddini   +2 more
doaj   +1 more source