Results 1 to 10 of about 68,646 (253)

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

The effects of a (poly)phenol‐rich food intervention on markers of exercise‐induced inflammation and oxidative stress: A randomised controlled trial

Experimental Physiology, EarlyView.
Abstract This study examined whether consuming a (poly)phenol‐rich food before strenuous muscle‐damaging exercise can modify post‐exercise markers of inflammation and oxidative stress. Using a double‐blinded, randomised, placebo‐controlled, between‐subjects design, 26 recreationally active males (n = 15) and females (n = 11) consumed higher‐(poly ...
Abrar Al Hebshi, Josh Thorley, Ana Rodriguez‐Mateos, Zicheng Zhang, Lewis J James, Tom Clifford   +5 more
wiley   +1 more source

Evaluation of theophylline therapeutic drug monitoring service

Zdravniški Vestnik, 2015
BackgroundTherapeutic monitoring of theophylline serum levels is required due to its narrow therapeutic range and marked interindividual pharmacokinetic variability.
Neža Rugelj, Katja Čvan Trobec, Mitja Pišlar, Pika Meško Brguljan, Mitja Košnik, Aleš Mrhar   +5 more
doaj  

Theophylline versus NSAID in the Treatment of Postdural Puncture  Headache in Obstetric Patients

Pakistan Armed Forces Medical Journal
Objective: To determine the effectiveness of oral Theophylline compared to Non-Steroidal Anti-Inflammatory Drugs in the management of postdural puncture headache in obstetric patients. Study Design: Quasi-experimental Study.
Tariq Mehmood, Rao Ali Shan Khan, Muhammad Awais Qarni, Kaukab Majeed Kayani, Usman Khalid, Hina Iftikhar   +5 more
doaj   +1 more source

To Study the Efficacy and Safety of Doxophylline and Theophylline in Bronchial Asthma [PDF]

Journal of Clinical and Diagnostic Research, 2015
Background: Asthma is a non communicable chronic disease prevalent all over the world. Two commonly used methylxanthines, theophylline and doxofylline were compared in the study in stable asthmatic patients at recommended doses by various spirometric
Sami Manzoor Margay, Samina Farhat, Sharanjit Kaur, Hilal Ahmad Teli   +3 more
doaj   +1 more source

Theophylline: a review of population pharmacokinetic analyses

Journal of Clinical Pharmacy and Therapeutics, 2016
Numerous population pharmacokinetic studies of theophylline have been conducted in paediatric and adult patients. The purpose of this review was to summarize the published studies concerning population pharmacokinetics of theophylline in patients of ...
Y.-J. Ma, De-Qi Jiang, J.-X. Meng, M.-X. Li, H.-H. Zhao, Y. Wang, L.-Q. Wang   +6 more
semanticscholar   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Predictive Factors for Efficacy and Safety of Prophylactic Theophylline for Extubation in Infants with Apnea of Prematurity.

PLoS ONE, 2016
PurposeThis study aimed to evaluate predictive factors involved in efficacy and safety in Japanese infants who received theophylline therapy to prevent apnea of prematurity (AOP) after weaning from mechanical ventilation.MethodsWe retrospectively ...
Tomoko Kondo, Yuki Kondo, Yuji Orita, Fumi Mitarai, Yoichi Ishitsuka, Mitsuru Irikura, Yoshihiro Shimodozono, Tsutomu Douchi, Yasuo Takeda, Tetsumi Irie   +9 more
doaj   +1 more source

Engineering an inducible gene expression system for Bacillus subtilis from a strong constitutive promoter and a theophylline-activated synthetic riboswitch

Microbial Cell Factories, 2016
BackgroundSynthetic riboswitches have been increasingly used to control and tune gene expression in diverse organisms. Although a set of theophylline-responsive riboswitches have been developed for bacteria, fully functional expression elements mediated ...
Wen-Jing Cui, Lai-Chuang Han, Jin-Tao Cheng, Zhong-Mei Liu, Li Zhou, Jun-Ling Guo, Zhe-Min Zhou   +6 more
semanticscholar   +1 more source

Can Spleen T1 Mapping Be Used as a Marker of Adenosine Response in Cardiac MRI?

NMR in Biomedicine, Volume 39, Issue 12, December 2026.
Patients with suspected coronary artery disease were scanned at 1.5 T with the routine clinical protocol for CMR. T1 mapping sequence at rest and during stress was included in which the spleen was visible. Splenic switch‐off was visually assessed in first‐pass images.
Sergio M. Solis‐Barquero, Ana Ezponda, Verónica Aramendía‐Vidaurreta, Marta Vidorreta, Marina Pascual, Gorka Bastarrika, Maria A. Fernández‐Seara   +6 more
wiley   +1 more source