Results 21 to 30 of about 24,767 (194)

The characteristics and costs of severe theophylline toxicity in a tertiary critical care unit in Eastern Cape Province, South Africa

South African Medical Journal, 2022
Background. Severe theophylline toxicity requiring haemodialysis accounts for approximately one-third of drug toxicity cases admitted to the Livingstone Tertiary Hospital (LTH) intensive care unit (ICU) in Gqeberha, South Africa, imposing a significant ...
JV Oxley-Oxland, R Freercks, D Baker, E van der Merwe   +3 more
doaj   +1 more source

Efficacy and safety profile of doxofylline compared to theophylline in asthma: a meta-analysis

Multidisciplinary Respiratory Medicine, 2019
Background Oral methylxanthines are effective drugs for the treatment of chronic obstructive respiratory disorders. The novel methylxanthine doxofylline, that has bronchodilator and anti-inflammatory activities, is not affected by the major drawback of ...
Paola Rogliani, Luigino Calzetta, Josuel Ora, Mario Cazzola, Maria Gabriella Matera   +4 more
doaj   +1 more source

Relation between Theophylline Serum Level with ECG Changes and Poison Severity Score (PSS) Among Some Theophylline Intoxicated Patients in Menofia Poison Control Center (MPCC) A Prospective Study [PDF]

Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2013
There are numerous toxins and drugs that can cause, in overdose, ECG changes, even in patients without history of cardiac pathology. Theophylline intoxication results in substantial morbidity and mortality, particularly in those with chronic ...
Nagwa Habib, Samy Hammad, Amira El Seidy, Safaa Amin   +3 more
doaj   +1 more source

Application of a Physiologically Based Pharmacokinetic Model to Study Theophylline Metabolism and Its Interactions With Ciprofloxacin and Caffeine

CPT: Pharmacometrics & Systems Pharmacology, 2016
Theophylline is a commonly used bronchodilator. However, due to its narrow therapeutic range, moderate elevation of serum concentration can result in adverse drug reactions (ADRs).
A Navid, DM Ng, SE Wong, FC Lightstone
doaj   +1 more source

RATEX: A Scalable RNA‐Based Platform for Logical and Multi‐Layered Cellular Programming

Angewandte Chemie International Edition, EarlyView.
RATEX integrated ribosome‐mediated transcription control with synthetic RNA regulators, enabling simultaneous processing of RNA, metabolite, and small‐molecule inputs through complex logic operations within a single transcript. The platform achieves up to 1,492‐fold gene regulation, multi‐input hybrid logic gates, RNA‐programmed signaling cascades, and
Hyunseop Goh, Hansol Kang, Chaeri Kim, Jongmin Kim   +3 more
wiley   +1 more source

CYP1A2 Gene Polymorphism and Theophylline Level in Asthma

Indonesian Biomedical Journal, 2019
BACKGROUND: Aminophylline (theophylline) is one of the most frequent asthma therapies in Indonesia, although it remains as a narrow therapy. The effects of drugs are individualized and strongly influenced by genetic, one of which is CYP1A2 gene ...
Amelia Lorensia, Zullies Ikawati, Tri Murti Andayani, Daniel Maranatha, Mariana Wahyudi   +4 more
doaj   +1 more source

Positive chronotropic effects of theophylline and cilostazol in patients with symptomatic sick sinus syndrome who have declined permanent pacing [PDF]

Reviews in Cardiovascular Medicine, 2020
Pacemakers are more commonly recommended than theophylline for sick sinus syndrome (SSS) treatment. The positive effects of cilostazol on bradyarrhythmias also have been reported.
In Tae Jin, Namsik Yoon, Hyung Ki Jeong, Ki Hong Lee, Hyung Wook Park, Jeong Gwan Cho
doaj   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Serum glucose potassium ratio compared to theophylline level as a predictor of severity and outcome in acute theophylline toxicity [PDF]

Zagazig Journal of Forensic Medicine and Toxicology
Background: Acute theophylline toxicity represents a significant hazard, mainly in developing countries, due to its severe consequences, the absence of an antidote, and the existence of many factors that affect the prognosis of acutely theophylline ...
sarah elmorsy, Hassan hany, Enas El-Taftazani, Sarah Eweda   +3 more
doaj   +1 more source

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

British Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup, Michel Tod, Laurent Bourguignon   +2 more
wiley   +1 more source