Results 141 to 150 of about 91,956 (289)

Zinc Finger E‐Box Binding Homeobox 1 Mediates Alcohol‐Induced Liver Disease

iNew Medicine, EarlyView.
Alcohol intake leads to the upregulation of ZEB1, which activates the YAP‐IL‐1β/MCP‐1 pathway, resulting in the activation of liver inflammation and the induction of hepatocyte apoptosis. ABSTRACT Hepatitis resulting from alcoholic liver disease (ALD) is an important risk factor for liver cancer. It is essential to understand the role of ALD to prevent
Boyu Zhang, Chunyang Zhang, Xiao Cui, Tao Xu, Xiangpeng Hu, Jiong Gu   +5 more
wiley   +1 more source

Risk profiling for cirrhosis and hepatocellular carcinoma in HFE hemochromatosis using mobilizable iron stores and alcohol consumption

Scientific Reports
HFE hemochromatosis (HH) may cause cirrhosis and hepatocellular carcinoma (HCC). Progression to these endpoints depends on the severity of iron overload and cofactors, such as alcohol.
Natasha D. P. Mitchell, Timothy G. St Pierre, Louise E. Ramm, Grant A. Ramm, John K. Olynyk   +4 more
doaj   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Alcohol Regulation and Crime [PDF]

We provide a critical review of research in economics that has examined causal relationships between alcohol use and crime. We lay out several causal pathways through which alcohol regulation and alcohol consumption may affect crime, including: direct ...
Carlos Dobkin, Christopher Carpenter
core   +2 more sources

Liver cirrhosis in 2021: Global Burden of Disease study.

PLoS ONE
BackgroundLiver cirrhosis is a chronic progressive disease caused by various liver injury mechanisms, characterized by irreversible fibrosis, hepatocyte degeneration and necrosis, and the formation of regenerative nodules, ultimately leading to liver ...
Hong Duo, Jian You, Siqi Du, Mengran Yu, Shaomei Wu, Pengpeng Yue, Xiao Cui, Yihui Huang, Jun Luo, Huaqin Pan, Qifa Ye   +10 more
doaj   +1 more source

Effect of Fecal Microbiota Transplantation on Arterial Stiffness in Alcohol-Related Liver Cirrhosis: A Prospective Pilot Study

Life
Background: Alcohol-related liver disease is frequently associated with systemic vascular dysfunction and increased arterial stiffness. This may contribute to adverse clinical outcomes.
Cristian Ichim, Adrian Boicean, Romeo Mihaila, Samuel Bogdan Todor, Paula Anderco, Victoria Birlutiu   +5 more
doaj   +1 more source

Epidemiology of Alcohol-Related Hepatitis, Alcohol-Related Cirrhosis, and Non-Alcohol-Related Cirrhosis in Alberta, Canada: An Administrative Data Validation and Population-Based Study

Background: Population-based studies evaluating the epidemiology of chronic liver diseases rely on accurate case definitions. This thesis aimed to develop new coding algorithms for alcohol- (AC) and non-alcohol-related cirrhosis (NAC) to use alongside a previously validated alcohol-related hepatitis (AH) coding algorithm to examine population-level AC,
openaire   +2 more sources

Minimum pricing of alcohol and its impact on consumption in the UK

A complete model of food demand is estimated for UK households, focusing on alcohol consumption both at home and outside. Using EFS data for 2005-06, several AIDS models have been estimated at different aggregation levels, thus defining a hierarchical ...
Arnoult, Matthieu H., Tiffin, J. Richard
core  

Advanced oxidation protein products and inflammatory markers in liver cirrhosis: a comparison between alcohol-related and HCV-related cirrhosis

, 2011
Advanced oxidation protein products (AOPPs) are protein markers of oxidative stress with pro-inflammatory properties that accumulated in liver cirrhosis.
Simon, Krzysztof, Pazgan-Simon, Monika, Zuwała-Jagiełło, Jolanta, Warwas, Maria   +3 more
core  

Soluble B7‐H6 as a Novel Diagnostic Biomarker for Post‐Hepatitis B Cirrhosis: A Clinical Value Study

Journal of Clinical Laboratory Analysis, EarlyView.
This study investigates the potential of soluble B7‐H6 (sB7‐H6) as a novel diagnostic biomarker for post‐hepatitis B cirrhosis. The infographic visually presents the following key points: (1) Liver Disease Progression: Chronic hepatitis B (CHB) progresses to liver cirrhosis (LC), with serum sB7‐H6 levels increasing stepwise as the disease advances. (2)
Kaiyong Chen, Luxuan Yang, Huaiwu Fu, Lei Cao, Zhu Li   +4 more
wiley   +1 more source