Results 121 to 130 of about 446,668 (261)

Diagnostic utility of two-dimensional speckle tracking imaging in detecting subclinical left ventricular systolic dysfunction in patients with alcohol-related disorders. [PDF]

Quant Imaging Med Surg
Zeng Y, Yang Y, Mo X, Liang S, Wu T, Zhang Q, Liu Y.   +6 more
europepmc   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Trajectories of hospital-presenting alcohol-related disorders between early and late adulthood: Exploring the role of mortality in a prospective study of a 1953 cohort. [PDF]

Addiction
Bishop L, Brännström L, Almquist YB.
europepmc   +1 more source

Contributions of an Internalizing Symptoms Polygenic Risk Score and Contextual Factors to Alcohol-Related Disorders in African American Young Adults. [PDF]

J Stud Alcohol Drugs, 2019
Rabinowitz JA, Musci R, Milam A, Benke K, Sisto D, Ialongo NS, Maher BS, Uhl G, Rosenbaum G, Reboussin B.   +9 more
europepmc   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

A historical review of alcohol-related health and social outcomes in Zambia

Global Journal of Medicine and Public Health
The purpose of this review was to summarize the history of health and social outcomes related to alcohol use in order to inform current strategies for addressing alcohol use disorders in Zambia.
Keyanna P Taylor, Jason Paltzer
doaj  

Alcohol-related disorders are associated with short-term outcomes in lung cancer patients undergoing VATS lobectomy: a 5-year retrospective analysis. [PDF]

Discov Oncol
Wu S, Zhu X, Pan K, Wu W, Chen Y, He X, Li H, Guan H.   +7 more
europepmc   +1 more source

Social class, social mobility and alcohol-related disorders in Swedish men and women: A study of four generations. [PDF]

PLoS One, 2018
Sidorchuk A, Goodman A, Koupil I.
europepmc   +1 more source

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Medicinal plants used by traditional medicine practitioners in treatment of alcohol-related disorders in Bushenyi District, southwestern Uganda. [PDF]

Front Pharmacol
Maling S, Kabakyenga J, Muchunguzi C, Olet EA, Namaganda M, Kahwa I, Alele PE.   +6 more
europepmc   +1 more source