Results 141 to 150 of about 4,496,597 (381)

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)

open access: yesMolecular Psychiatry, 2017
Alcohol consumption has been linked to over 200 diseases and is responsible for over 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for example, ALDH2 and ADH1B, are strongly associated with alcohol ...
Toni‐Kim Clarke   +12 more
semanticscholar   +1 more source

Risk of Hepatotoxicity in Patients With Gout Treated With Febuxostat or Benzbromarone: A Propensity Score–Matched Cohort Study

open access: yesArthritis Care &Research, EarlyView.
Objective The objective of this study was to evaluate and compare the risk of hepatotoxicity associated with the use of febuxostat and benzbromarone in patients with gout. Methods New users of febuxostat or benzbromarone with monitoring of liver function at least three times in a year after initiation of the study drugs were identified from an ...
Wenyan Sun   +8 more
wiley   +1 more source

Gastrointestinal Perforation as a Safety Concern Among Patients With Rheumatoid Arthritis Receiving JAK Inhibitor Therapy: A Systematic Review and Network Meta‐Analysis

open access: yesArthritis Care &Research, EarlyView.
Objective Gastrointestinal perforation (GIP) is a rare and life‐threatening safety concern associated with JAK inhibitors (JAKi). We aimed to review the evidence regarding the risk of GIP associated with the use of JAKi in patients with rheumatoid arthritis (RA) using a systematic review and network meta‐analysis approach.
Thipsukhon Sathapanasiri   +7 more
wiley   +1 more source

“Fourteen Dollars for One Beer!” Pre‐drinking is associated with high‐risk drinking among Victorian young adults

open access: yesAustralian and New Zealand Journal of Public Health, 2013
Objective: Pre‐drinking entails consuming alcohol before attending licensed venues. We examined the relationship between pre‐drinking, intention to get drunk and high‐risk drinking among Victorians aged 18–24 years, to consider whether reducing pre ...
Sarah MacLean, Sarah Callinan
doaj   +1 more source

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

open access: yesAdvanced Biology, EarlyView.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers   +3 more
wiley   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

open access: yesAdvanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu   +12 more
wiley   +1 more source

Implementation of effective alcohol control strategies is needed at large sports and entertainment events

open access: yesAustralian and New Zealand Journal of Public Health, 2012
Objective: To assess the implementation and effectiveness of strategies and actions to eliminate and/or reduce alcohol‐related problems at large sports and entertainment events in New Zealand. Methods: We conducted site visits and monitoring observations
Mark Lyne, Andrew Galloway
doaj   +1 more source

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