Results 21 to 30 of about 1,412,279 (262)

Short- and long-term effects of ethanol administration in vivo on rat liver HMG-CoA reductase and cholesterol 7α-hydroxylase activities

Journal of Lipid Research, 1977
Short- and long-term effects of ethanol on HMG-CoA reductase (EC 1.1.1.34) and cholesterol 7α-hydroxylase activities in rat liver have been investigated.
M R Lakshmanan, R L Veech
doaj   +1 more source

Cholesterol as a modulator of cannabinoid receptor CB2 signaling

Scientific Reports, 2021
Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases basal ...
Alexei Yeliseev, Malliga R. Iyer, Thomas T. Joseph, Nathan J. Coffey, Resat Cinar, Lioudmila Zoubak, George Kunos, Klaus Gawrisch   +7 more
doaj   +1 more source

Sex differences in nicotine-enhanced Pavlovian conditioned approach in rats

Biology of Sex Differences, 2019
Background Nicotine exposure enhances Pavlovian conditioned approach (PCA), or the learned approach to reward-predictive cues. While females show elevated approach to conditioned stimuli compared to males, potentially indicating heightened addiction ...
Sierra J. Stringfield, Aric C. Madayag, Charlotte A. Boettiger, Donita L. Robinson   +3 more
doaj   +1 more source

Time-varying SUVr reflects the dynamics of dopamine increases during methylphenidate challenges in humans

Communications Biology, 2023
Combined PET imaging and mathematical simulations reveal that the rate of dopamine increase in the striatum underlies self-reports of drug “high” in response to oral and intravenous methylphenidate challenges in ...
Dardo Tomasi, Peter Manza, Jean Logan, Ehsan Shokri-Kojori, Michele-Vera Yonga, Danielle Kroll, Dana Feldman, Katherine McPherson, Catherine Biesecker, Evan Dennis, Allison Johnson, Kai Yuan, Wen-Tung Wang, John A. Butman, Gene-Jack Wang, Nora D. Volkow   +15 more
doaj   +1 more source

The Community-Based Medication-First program for opioid use disorder: a hybrid implementation study protocol of a rapid access to buprenorphine program in Washington State

Addiction Science & Clinical Practice, 2022
Background Opioid use disorder (OUD) is a serious health condition that is effectively treated with buprenorphine. However, only a minority of people with OUD are able to access buprenorphine.
Caleb J. Banta-Green, Mandy D. Owens, Jason R. Williams, Jeanne M. Sears, Anthony S. Floyd, Wendy Williams-Gilbert, Susan Kingston   +6 more
doaj   +1 more source

Chronic Binge Alcohol and Ovarian Hormone Loss Dysregulate Circulating Immune Cell SIV Co-Receptor Expression and Mitochondrial Homeostasis in SIV-Infected Rhesus Macaques

Biomolecules, 2022
Effective antiretroviral therapy (ART) has transitioned HIV to a chronic disease, with more than 50% of people living with HIV (PLWH) being over the age of 50.
Patrick M. McTernan, Robert W. Siggins, Anna Catinis, Angela M. Amedee, Liz Simon, Patricia E. Molina   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Collectivity of Drinking Behavior Among Adolescents: An Analysis of the Norwegian ESPAD Data 1995-2011

Nordic Studies on Alcohol and Drugs, 2014
AIMS – The aim of the current study was to test empirically two predictions from Skog’s theory of collectivity of drinking behavior, using time series data from Norwegian adolescents.
Brunborg Geir Scott, Bye Elin K., Rossow Ingeborg   +2 more
doaj   +1 more source

Naloxone’s dose-dependent displacement of [11C]carfentanil and duration of receptor occupancy in the rat brain

Scientific Reports, 2022
The continuous rise in opioid overdoses in the United States is predominantly driven by very potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls).
Yeona Kang, Kelly A. O’Conor, Andrew C. Kelleher, Joseph Ramsey, Abolghasem Bakhoda, Seth M. Eisenberg, Wenjing Zhao, Tyler Stodden, Torben D. Pearson, Min Guo, Nina Brown, Jeih-San Liow, Joanna S. Fowler, Sung Won Kim, Nora D. Volkow   +14 more
doaj   +1 more source

Alcohol. [PDF]

BMJ, 1982
Abstract There is evidence for a dose-response relationship between alcohol consumption and risk of liver cirrhosis, cancers of the oropharynx, larynx, oesophagus, rectum (beer only), liver, and female breast, and violent death, but the relationship between alcohol consumption and cardiovascular disease is more complex.
openaire   +2 more sources