Results 71 to 80 of about 1,516,378 (315)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

Tobacco use and nicotine dependence among people living with HIV who drink heavily in South Africa: a cross-sectional baseline study

open access: yesBMC Public Health, 2019
Background People living with HIV (PLWH) who drink alcohol and use tobacco are particularly vulnerable to tobacco-induced diseases due to an already compromised immune system. This study investigated the prevalence and factors associated with tobacco use
Catherine O. Egbe   +6 more
doaj   +1 more source

The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics

open access: yesCell Death Discovery, 2023
The proliferation and differentiation of hepatic progenitor cells (HPCs) drive the homeostatic renewal of the liver under diverse conditions. Liver regeneration is associated with an increase in Axin2+Cnr1+ HPCs, along with a marked increase in the ...
Bani Mukhopadhyay   +8 more
doaj   +1 more source

ALCOHOLISM. [PDF]

open access: yesThe Lancet, 1902
n ...
openaire   +2 more sources

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

open access: yesFEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui   +5 more
wiley   +1 more source

The impact of changes in opioid dependency treatment upon COVID-19 transmission in Sydney, Australia: a retrospective longitudinal observational study

open access: yesBMC Public Health
Background In April 2020, in response to the COVID-19 public health emergency, South Eastern Sydney Local Health District (SESLHD) Drug and Alcohol services modified their delivery of opioid dependency treatment (ODT) to reduce spread of COVID-19 and ...
Benjamin T. Trevitt   +5 more
doaj   +1 more source

Estimation of the Accuracy of Method for Quantitative Determination of Volatile Compounds in Alcohol Products [PDF]

open access: yesProceedings of BSTU, Series: Chemistry, Organic Substances Technology and Biotechnology. No.4, 2014. P.201-205, 2016
Results of the estimation of the precision for determination volatile compounds in alcohol-containing products by gas chromatography: acetaldehyde, methyl acetate, ethyl acetate, methanol, isopropyl alcohol, propyl alcohol, isobutyl alcohol, butyl alcohol, isoamyl alcohol are presented. To determine the accuracy, measurements were planned in accordance
arxiv  

Alcohol consumption and alcohol policy

open access: yesTURKISH JOURNAL OF MEDICAL SCIENCES, 2020
Alcohol is a unique addictive substance used by many people for different reasons. Alcohol use affects not only the users but also the family and the whole society in a negative way. Alcohol is one of the most commonly used substances for entertainment purposes in the world and 1 in 3 people is a current drinker.
Mustafa Necmi İLHAN, Dilek YAPAR
openaire   +3 more sources

Protein O‐glycosylation in the Bacteroidota phylum

open access: yesFEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns   +2 more
wiley   +1 more source

User-centered design of contingency management for implementation in opioid treatment programs: a qualitative study

open access: yesBMC Health Services Research, 2019
Background Contingency management (CM) is one of the only behavioral interventions shown to be effective for the treatment of opioid use disorders when delivered alone and in combination with pharmacotherapy.
Sara J. Becker   +6 more
doaj   +1 more source

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