Results 71 to 80 of about 4,496,597 (381)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Sleep disturbances are associated with cortical and subcortical atrophy in alcohol use disorder

Translational Psychiatry, 2021
Sleep disturbances are prominent in patients with alcohol use disorder (AUD) and predict relapse. So far, the mechanisms underlying sleep disruptions in AUD are poorly understood.
Rui Zhang, Dardo Tomasi, Peter Manza, Ehsan Shokri-Kojori, Sukru B. Demiral, Dana E. Feldman, Danielle S. Kroll, Catherine L. Biesecker, Katherine L. McPherson, Gene-Jack Wang, Corinde E. Wiers, Nora D. Volkow   +11 more
doaj   +1 more source

Is alcohol dependence best viewed as a chronic relapsing disorder? [PDF]

, 2011
This 'For Debate' paper starts by recognizing the growing trend towards considering alcohol dependence as a chronic relapsing disorder. We argue that the adoption of this model results from focusing on those in treatment for alcohol dependence rather ...
American Psychiatric Association, Andreasson, Babor, Babor, Breese, Cacciola, Caetano, Cartwright, Chan, Cohen, Cunningham, Cunningham, Cunningham, Dawson, Dawson, Dawson, Dawson, de Bruijn, Ducci, Edwards, Edwards, Edwards, Edwards, Enoch, Fillmore, Finney, Gorman, Grant, Heather, Hingson, Institute of Medicine, Jacob, Kalant, Klingemann, Ko, Koob, Kreitman, Leake, Leshner, Linke, McAweeney, McCambridge, McKay, McKay, McLellan, McLellan, McLellan, McLellan, McLellan, Merline, Midanik, Miller, Miller, Miller, Miller, Moss, O'Brien, Orford, Penick, Prochaska, Room, Room, Rose, Rosenthal, Rosenthal, Saitz, Schuckit, Schuckit, Scott, Stockwell, Timko, Tucker, Vaillant, Volkow, Weisner, Weisner, Weisner, Willenbring, World Health Organization, Wrase   +79 more
core   +2 more sources

Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?

Molecular Oncology, EarlyView.
 
Chen‐xi Li, Zhong‐cheng Gong
wiley   +1 more source

Associations between simultaneous use of alcohol and cannabis and cannabis-related problems in 2014–2016: evidence from the Washington panel survey

Journal of Cannabis Research
Background To address the research question of how simultaneous users of alcohol and cannabis differ from concurrent users in risk of cannabis use problems after the recreational marijuana legalization in Washington State.
Yachen Zhu, Yu Ye, Thomas K. Greenfield, William C. Kerr   +3 more
doaj   +1 more source

Relationship between tonic and phasic craving for alcohol. [PDF]

, 2018
BackgroundMultiple measures are utilized to assess alcohol craving, often interchangeably. Little is known about the relationship between tonic and phasic craving.
Hartwell, Emily E, Ray, Lara A
core   +2 more sources

Alcohol Use Disorder and Depressive Disorders

Alcohol research : current reviews, 2019
Alcohol use disorder (AUD) and depressive disorders are among the most prevalent psychiatric disorders and co-occur more often than expected by chance.
R. McHugh, R. Weiss
semanticscholar   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Characteristics of the Washington cannabis market from 2014 to 2016

Journal of Cannabis Research, 2022
Background The state of Washington legalized cannabis for adult use in 2012 and retail stores began to open in 2014. While details of the legal market have been tracked by the state, the total market for cannabis and characteristics of purchasers can ...
William C. Kerr, Yu Ye
doaj   +1 more source

Explaining trends in alcohol-related harms in Scotland 1991–2011 (II): policy, social norms, the alcohol market, clinical changes and a synthesis [PDF]

, 2016
Objective: To provide a basis for evaluating post-2007 alcohol policy in Scotland, this paper tests the extent to which pre-2007 policy, the alcohol market, culture or clinical changes might explain differences in the magnitude and trends in alcohol ...
Beeston, C., Bouttell, J., Craig, L., Craig, P., Graham, L., Lakha, F., Lewsey, J., MacPherson, M., McAdams, R., McCartney, G., Minton, J., Parkinson, J., Robinson, M., Shipton, D., Taulbut, M., Walsh, D.   +15 more
core   +1 more source