Results 81 to 90 of about 4,580,900 (353)

Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation

Nature Communications
Dopaminergic signaling shapes large-scale brain network architecture, constraining neural communication along a principal gradient that spans unimodal sensorimotor to transmodal association cortices.
Dardo Tomasi, Peter Manza, Şükrü Barış Demiral, Weizheng Yan, Kylee B. Miller, Faith Veenker, Joshua Zhao, Christina Lildharrie, Michele-Vera Yonga, Sarah Abey, Michaelene VanDine, Gene-Jack Wang, Nora D. Volkow   +12 more
doaj   +1 more source

The impact of poly-traumatization on treatment outcomes in young people with substance use disorders

BMC Psychiatry, 2021
Background It is believed that clients with psychological trauma experiences have a poor prognosis with regard to treatment participation and outcomes for substance use disorders.
Sidsel Karsberg, Morten Hesse, Michael Mulbjerg Pedersen, Ruby Charak, Mads Uffe Pedersen   +4 more
doaj   +1 more source

Alcohol Use Disorder and Depressive Disorders

Alcohol research : current reviews, 2019
Alcohol use disorder (AUD) and depressive disorders are among the most prevalent psychiatric disorders and co-occur more often than expected by chance.
R. McHugh, R. Weiss
semanticscholar   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Sleep disturbances are associated with cortical and subcortical atrophy in alcohol use disorder

Translational Psychiatry, 2021
Sleep disturbances are prominent in patients with alcohol use disorder (AUD) and predict relapse. So far, the mechanisms underlying sleep disruptions in AUD are poorly understood.
Rui Zhang, Dardo Tomasi, Peter Manza, Ehsan Shokri-Kojori, Sukru B. Demiral, Dana E. Feldman, Danielle S. Kroll, Catherine L. Biesecker, Katherine L. McPherson, Gene-Jack Wang, Corinde E. Wiers, Nora D. Volkow   +11 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Adverse Childhood Experiences and Their Association with Alcohol Abuse by Alaska Adults [PDF]

, 2015
Note: The PDF of this article includes a web supplement which did not appear in the original print version of the article.This article examines the prevalence of adverse childhood experiences (ACEs) — such as abuse and household dysfunction in childhood —
Rivera, Marny, Sidmore, Patrick
core  

Modeling alcohol use disorder severity: An integrative structural equation modeling approach [PDF]

, 2013
Background: Alcohol dependence is a complex psychological disorder whose phenomenology changes as the disorder progresses. Neuroscience has provided a variety of theories and evidence for the development, maintenance, and severity of addiction; however ...
Bacio, GA, Courtney, KE, Moallem, NR, Ray, LA   +3 more
core   +2 more sources

The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics

Cell Death Discovery, 2023
The proliferation and differentiation of hepatic progenitor cells (HPCs) drive the homeostatic renewal of the liver under diverse conditions. Liver regeneration is associated with an increase in Axin2+Cnr1+ HPCs, along with a marked increase in the ...
Bani Mukhopadhyay, Kellie Holovac, Kornel Schuebel, Partha Mukhopadhyay, Resat Cinar, Sindhu Iyer, Cheryl Marietta, David Goldman, George Kunos   +8 more
doaj   +1 more source

Diagnosis and Pharmacotherapy of Alcohol Use Disorder: A Review

Journal of the American Medical Association (JAMA), 2018
Importance Alcohol consumption is associated with 88 000 US deaths annually. Although routine screening for heavy alcohol use can identify patients with alcohol use disorder (AUD) and has been recommended, only 1 in 6 US adults report ever having been ...
H. Kranzler, M. Soyka
semanticscholar   +1 more source