Results 81 to 90 of about 4,677,837 (402)

The short-term impact of the alcohol act on alcohol-related deaths and hospital admissions in Scotland: a natural experiment [PDF]

, 2018
Background and aim: The introduction of the Alcohol Act in Scotland on 1 October 2011, which included a ban on multi-buy promotions, was likely associated with a fall in off-trade alcohol sales in the year after its implementation.
Babor, Beeston, Bellis, Black, Booth, Bray, Chikritzhs, Cleveland, Craig, Craig, Fretheim, Holmes, Holmes, Information Services Division, Jarosz, Jones, Leon, Linden, Ludbrook, Meng, Nakamura, Nakamura, Robinson, Robinson, St Clair, Stockwell, Vocht, Wagenaar, Wagenaar, Whyte, World Health Organization, Zhao   +31 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

The impact of poly-traumatization on treatment outcomes in young people with substance use disorders

BMC Psychiatry, 2021
Background It is believed that clients with psychological trauma experiences have a poor prognosis with regard to treatment participation and outcomes for substance use disorders.
Sidsel Karsberg, Morten Hesse, Michael Mulbjerg Pedersen, Ruby Charak, Mads Uffe Pedersen   +4 more
doaj   +1 more source

Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]

, 2015
The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia, Pandol, Stephen J, Waldron, Richard T   +2 more
core   +1 more source

Effect of the Uniform Accident and Sickness Policy Provision Law on Alcohol Screening and Intervention in Trauma Centers [PDF]

, 2006
Outlines how a law allowing insurers to deny payment for injury claims if alcohol or drug use was involved prevents alcohol screening and interventions to reduce alcohol use, repeat injuries, and healthcare costs.
Deanna Lewis
core   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics

Cell Death Discovery, 2023
The proliferation and differentiation of hepatic progenitor cells (HPCs) drive the homeostatic renewal of the liver under diverse conditions. Liver regeneration is associated with an increase in Axin2+Cnr1+ HPCs, along with a marked increase in the ...
Bani Mukhopadhyay, Kellie Holovac, Kornel Schuebel, Partha Mukhopadhyay, Resat Cinar, Sindhu Iyer, Cheryl Marietta, David Goldman, George Kunos   +8 more
doaj   +1 more source

Trade and health: how World Trade Organization(WTO) law affects alcohol and public health [PDF]

, 2008
The alcohol field is becoming more aware of the consequences of world trade law for alcohol policies. However, there is a need for greater clarity about the different effects of trade on alcohol-related harm.
Gould, Grieshaber-Otto, Grieshaber-Otto, Ziegler, Gould, Bloche, Shaffer, Endal, Correa, Ranson, Saspin, Baumberg, Drager, Fidler, Howse, Borland, Gould, Stoller, Alavaikko, Ferris, Vingilis, Room, Chaloupka, Secretariat of the Pacific Community, Gould, Taylor, Chaloupka, Taylor, Kuo, Anderson, Shaw, Sinclair, Callard, Waitzkin, United Nations Conference on Trade and Development, United Nations Conference on Trade and Development, Anderson, Room, Room, McGrady, Bettcher, Chaloupka   +41 more
core   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure

Translational Psychiatry, 2021
Alcohol use disorder (AUD) is highly comorbid with depression. Withdrawal from chronic alcohol drinking results in depression and understanding brain molecular mechanisms that drive withdrawal-related depression is important for finding new drug targets ...
Wei-Yang Chen, Hu Chen, Kana Hamada, Eleonora Gatta, Ying Chen, Huaibo Zhang, Jenny Drnevich, Harish R. Krishnan, Mark Maienschein-Cline, Dennis R. Grayson, Subhash C. Pandey, Amy W. Lasek   +11 more
doaj   +1 more source