Results 51 to 60 of about 1,098,942 (360)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Personalized feedback based on a drink-pouring exercise may improve knowledge of, and adherence to, government guidelines for alcohol consumption [PDF]

, 2015
Background Although most people are aware of government guidelines for alcohol consumption, few have accurate knowledge of these and fewer still use these guidelines to monitor their drinking.
Ajzen, Becker, Bewick, Boles, Centers for Disease Control, Cherpitel, Devos-Comby, Fisher, Furtwängler, George, Gill, Gill, Gill, Gill, Gill, Gore, Harrison, Hasking, Herring, Hoskins, Jones, Kaskutas, Kerr, Kerr, Kerr, Kerr, Kulik, Merline, Moreira, Moss, Nicholls, Steele, Szmigin, Turrisi, Visser, Visser, Visser, Visser, White, White, White, Wild   +41 more
core   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Association between temperature, sunlight hours and alcohol consumption.

PLoS ONE, 2019
BACKGROUND:Alcohol is a major risk factor for liver cirrhosis. Recently, it was proposed that colder climate might causally lead to increased consumption of alcohol.
Hannes Hagström, Linnea Widman, Erik von Seth   +2 more
doaj   +1 more source

Socioeconomic Inequalities in Alcohol and Tobacco Consumption: A National Ecological Study in Mexican Adolescents

The Scientific World Journal, 2023
Alcohol and cigarettes are the psychoactive substances that adolescents use most frequently. When both addictions are combined, they carry the worst burden of disease globally.
Leticia Ávila-Burgos, Rebeca Guzmán-Saldaña, María de Lourdes Márquez-Corona, América Patricia Pontigo-Loyola, Sonia Márquez-Rodríguez, Mariana Mora-Acosta, Gladys Remigia Acuña-González, Antonio Hernández-Morales, Carlo Eduardo Medina-Solís   +8 more
doaj   +1 more source

A Comparison of Sociodemographic Correlates of Cigarette, Alcohol, and Energy Drink Consumption among High School Students in the United States, 2010-2015 [PDF]

, 2018
OBJECTIVE: Despite growing awareness about the harmful physiological effects of energy drinks, especially among young people, there is little regulation governing the marketing and sale of these products to adolescents.
Cha, Eun Me, Hoelscher, Deanna M., Ranjit, Nalini   +2 more
core   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students [PDF]

, 2017
Background: Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms ...
Adkins, Amy, Aliev, Fazil, Cho, Seung B., Cooke, Megan E., Dick, Danielle M., Edwards, Alexis C., Kendler, Kenneth S., Kitchens, James N., Neale, Zoe, Pedersen, Kimberly, Riley, Brien P., Salvatore, Jessica E., Savage, Jeanne E., Sun, Cuie, Webb, Bradley T., Williamson, Vernell S., Wolen, Aaron R.   +16 more
core   +2 more sources

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source