Results 61 to 70 of about 3,717,469 (406)

Dupuytren's disease, alcohol consumption and alcoholism [PDF]

Scandinavian Journal of Primary Health Care, 2001
To assess the relation between alcohol consumption and Dupuytren's disease.The participants were recruited from a previous study on Dupuytren's disease carried out in 1981-82 as part of a cohort study. Men with Dupuytren's disease in the former study and a control group were invited.
Kristján G. Gudmundsson, Thorbjorn Jonsson, Reynir Arngrímsson   +2 more
openaire   +3 more sources

Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study

British medical journal, 2018
Objective To examine the association between alcohol consumption and risk of dementia. Design Prospective cohort study. Setting Civil service departments in London (Whitehall II study).
S. Sabia, A. Fayosse, J. Dumurgier, A. Dugravot, T. Akbaraly, A. Britton, M. Kivimäki, A. Singh‐Manoux   +7 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Alcohol use is prevalent among adults with the fontan circulation but does not correlate with liver disease

International Journal of Cardiology Congenital Heart Disease, 2022
Background: Alcohol consumption is associated with an increased risk of liver disease. There are limited studies on the epidemiology of alcohol use and its effects on Fontan-associated liver disease (FALD) in adulthood.
Shravani Chintakindi, Bendelyn Asante Boateng, Irine Vodkin, Nicole Herrick, Maria Moceri, Deborah Raleigh, Edward Wang, Howaida El-Said, Ryan Reeves, Jose Silva Sepulveda, Laith Alshawabkeh   +10 more
doaj   +1 more source

Regional alcohol consumption and alcohol-related mortality in Great Britain: novel insights using retail sales data [PDF]

, 2015
Background: Regional differences in population levels of alcohol-related harm exist across Great Britain, but these are not entirely consistent with differences in population levels of alcohol consumption. This incongruence may be due to the use of self-
McCartney, Gerry, Robinson, Mark, Shipton, Deborah, Walsh, David, Whyte, Bruce   +4 more
core   +1 more source

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source

Moderate alcohol consumption and cognitive risk

Neuropsychiatric Disease and Treatment, 2011
Edward J Neafsey, Michael A CollinsDepartment of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, USAAbstract: We reviewed 143 papers that described the relationship between moderate drinking of
Neafsey EJ, Collins MA
doaj  

A UK student survey investigating the effects of consuming alcohol mixed with energy drinks on overall alcohol consumption and alcohol-related negative consequences

Preventive Medicine Reports, 2016
Previous research reported positive associations between alcohol mixed with energy drink (AMED) consumption and overall alcohol consumption. However, results were largely based on between-subjects comparisons comparing AMED consumers with alcohol-only ...
Sean J. Johnson, Chris Alford, Karina Stewart, Joris C. Verster   +3 more
doaj   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source