Results 81 to 90 of about 3,717,469 (406)

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

Analysis of Strategies Designed to Reduce Sales of Alcohol and Tobacco to Underage Persons: A Preliminary Report [PDF]

, 2012
Alaska has one of the highest per capita alcohol consumption rates in the nation, and the prevalence of alcohol dependence and alcohol abuse at 14 percent is twice the national average of seven percent. Of special concern is the prevention of alcohol use
Parker, Khristy, Rivera, Marny
core  

Moderate alcohol consumption alters both leucocyte gene expression profiles and circulating proteins related to immune response and lipid metabolism in men [PDF]

Moderate alcohol consumption has various effects on immune and inflammatory processes, which could accumulatively modulate chronic disease risk. So far, no comprehensive, integrative profiling has been performed to investigate the effects of longer-term ...
Erk, M.J., van, Hendriks, H.F.J., Joosten, M.M., Pellis, E.P.M., Witkamp, R.F.   +4 more
core   +2 more sources

The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice. [PDF]

, 2015
RATIONALE Using the drinking-in-the-dark (DID) model, we compared the effects of a novel mu-opioid receptor antagonist, GSK1521498, with naltrexone, a licensed treatment of alcohol dependence, on ethanol consumption in mice.
C Giuliano, C Giuliano, David N. Stephens, David R. Wille, DM Ignar, DN Stephens, DW Oslin, EA Rabiner, Edward T. Bullmore, EE Codd, F Kiefer, GH Jones, H Wit de, H Ziauddeen, HM Pettinati, JR Volpicelli, JS Rhodes, Kay Maltby, LA Berner, LA Parker, LD Middaugh, LS Hwa, Manolo Mugnaini, NK Kamdar, P Monti, PJ Nathan, PJ Nathan, Pradeep Nathan, S Loeber, Sam R. Miller, Sandra Sanchez-Roige, Tamzin L. Ripley, TJ Phillips, TL Ripley   +33 more
core   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Is alcohol consumption associated with poor academic achievement in university students?

International Journal of Preventive Medicine, 2013
Background: We assessed associations between educational achievement and alcohol consumption. Methods: We employed five alcohol consumption measures (length of time of and amount consumed during most recent drinking occasion, frequency of alcohol ...
Walid El Ansari, Christiane Stock, Claire Mills   +2 more
doaj  

Alcohol consumption as a risk factor for tuberculosis: meta-analyses and burden of disease

European Respiratory Journal, 2017
Meta-analyses of alcohol use, alcohol dosage and alcohol-related problems as risk factors for tuberculosis incidence were undertaken. The global alcohol-attributable tuberculosis burden of disease was also re-estimated. Systematic searches were conducted,
Sameer Imtiaz, K. Shield, M. Roerecke, A. Samokhvalov, K. Lönnroth, J. Rehm   +5 more
semanticscholar   +1 more source

Alcohol consumption and lifetime change in cognitive ability:a gene × environment interaction study [PDF]

, 2014
Studies of the effect of alcohol consumption on cognitive ability are often confounded. One approach to avoid confounding is the Mendelian randomization design.
AJ Birley, David C. Liewald, EJ Neafsey, F Panza, F Zanjani, G Davey Smith, Gail Davies, Geraldine McNeill, HK Seitz, Ian J. Deary, IHM Friesema, IJ Deary, IJ Deary, IJ Deary, J Corley, Janie Corley, John M. Starr, JW Kim, KJ Anstey, LF Masson, LM Hines, LM Houlihan, M Grønbæk, M Richards, M Zgombic-Knight, MA Collins, MF Folstein, Office of Population Censuses and Surveys, Office of Population Censuses and Surveys, P Brennan, PA Dickson, PL Brennan, S Ebrahim, S Sabia, Scottish Council for Research in Education, SJ Lewis, SL Au Yeung, Stuart J. Ritchie, Timothy C. Bates, Y Li   +39 more
core   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source

Colorectal Cancer and Alcohol Consumption—Populations to Molecules

Cancers, 2018
Colorectal cancer (CRC) is a major cause of morbidity and mortality, being the third most common cancer diagnosed in both men and women in the world. Several environmental and habitual factors have been associated with the CRC risk.
M. Rossi, Muhammad Jahanzaib Anwar, Ahmad Usman, A. Keshavarzian, Faraz Bishehsari   +4 more
semanticscholar   +1 more source