Results 91 to 100 of about 546,315 (303)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence [PDF]

, 2015
Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non-selective phosphodiesterase inhibitor, to ...
Becker, Howard C., Bell, Richard L., Cui, Changhai, Egli, Mark, Franklin, Kelle M., Johnson, Kirk W., Lopez, Marcelo F.   +6 more
core   +1 more source

Acute Liver Injury in a Patient with Alcohol Dependence: A Case Resembling Autoimmune Hepatitis or Drug-Induced Liver Injury

Case Reports in Gastroenterology, 2014
Some patients with alcohol dependence may initially present with atypical laboratory and histological features resembling autoimmune hepatitis (AIH) or drug-induced liver injury (DILI).
Masahiro Hayashi, Tatsuo Kanda, Masato Nakamura, Tatsuo Miyamura, Shin Yasui, Shingo Nakamoto, Shuang Wu, Makoto Arai, Fumio Imazeki, Osamu Yokosuka   +9 more
doaj   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Acamprosate for alcohol dependence

São Paulo Medical Journal
BACKGROUND: Alcohol dependence is among the main leading health risk factors in most developed and developing countries. Therapeutic success of psychosocial programs for relapse prevention is moderate, but could potentially be increased by an adjuvant ...
Susanne Rösner, Andrea Hackl-Herrwerth, Stefan Leucht, Philippe Lehert, Simona Vecchi, Michael Soyka   +5 more
doaj   +1 more source

Changes in concentration of visfatin during four weeks of inpatient treatment of alcohol dependent males

Alcoholism and Drug Addiction, 2015
Introduction: Visfatin is a protein which belongs to the adiponectines, and exhibits insulinomimetic properties. A high concentration of visfatin may be directly related to an ongoing inflammatory process in the body.
Damian Czarnecki, Zofia Rosińska, Ewa Żekanowska, Marcin Ziółkowski, Barbara Góralczyk, Edward Jacek Gorzelańczyk, Marek Kunc, Anna Długosz, Jacek Budzyński, Beata Łangowska-Grodzka, Krzysztof Opozda   +10 more
doaj   +1 more source

The Effect of Olanzapine on Craving and Alcohol Consumption

, 2006
Previous studies have indicated that olanzapine decreases craving after a priming dose of alcohol, that craving after a priming dose of alcohol is greater among individuals with the seven-repeat allele of the DRD4 variable number of tandem repeats (VNTR)
Davidson, Dena, Hutchinson, Kent E, Peters, Annie, Ray, Lara, Rutter Goodworth, Marie-Christine, Sandman, Erica, Swift, Robert   +6 more
core  

UK Alcohol Treatment trial: client-treatment matching effects [PDF]

, 2008
Aim To test a priori hypotheses concerning client–treatment matching in the treatment of alcohol problems and to evaluate the more general hypothesis that client–treatment matching adds to the overall effectiveness of treatment. Design Pragmatic,
Beutler, Booth, Brehm, Brown, Burke, Bühringer, Clifford, Clifford, Clifford, Cooney, Cooney, Copello, Deci, Department of Health., Drummond, Ewing, Finney, Finney, Flay, Franks, Goldberg, Hall, Heather, Heather, Humphreys, Institute of Medicine., Jones, Karno, Kissin, Lindstrom, Longabaugh, Mattson, McClelland, McLachlan, McLellan, McLellan, McMahon, Miller, Miller, Miller, Miller, Miller, Moos, Moos, Moyer, Ogborne, Orford, Prochaska, Project MATCH Research Group., Project MATCH Research Group., Project MATCH Research Group., Raistrick, Raistrick, Randall, Sackett, Schwartz, Sobell, Sobell, Spielberger, Stiles, Stout, Tober, Truax, UKATT Research Team., UKATT Research Team., UKATT Research Team., Wampold, Wampold   +67 more
core   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Nicotine dependence and readiness to quit tobacco among past and present alcohol abusers in Chennai, India - a comparative study

Tobacco Induced Diseases, 2018
Background Tobacco and alcohol are among the top causes of preventable deaths in the world, in most cases both these substances are used together. This study aims to compare the differences in nicotine dependence and the readiness to quit among past and ...
Arun Kumar Sundaragopal, Preetha Elizabeth Chaly, Shyam Sivasamy   +2 more
doaj   +1 more source