Results 71 to 80 of about 546,315 (303)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings [PDF]

, 2016
Herein, we have reviewed the role of glutamate, the major excitatory neurotransmitter in the brain, in a number of neurochemical, -physiological, and -behavioral processes mediating the development of alcohol dependence.
Aal-Aaboda, Abe, Abulseoud, Ady, Agrawal, Alasmari, Alhaddad, Arriza, Babu, Bard, Bauer, Beattie, Begleiter, Bell, Bell, Bell, Bell, Bell, Bell, Besheer, Besheer, Besheer, Bischoff, Bockaert, Bondy, Bäckström, Béïque, Cannady, Cannella, Carlezon, Chandler, Chandler, Chefer, Chen, Chen, Cicero, Cloninger, Cohen-Gilbert, Comasco, Cotton, Cowen, Cozzoli, Cozzoli, Cozzoli, Crabbe, Danbolt, Das, Ding, Ding, Domart, Edenberg, Edenberg, Ehlers, El-Husseini, Ende, Enoch, Falco, Flatscher-Bader, Floyd, Fotuhi, Funke, Garbett, Garner, Gass, Gass, Goodwani, Gould, Goulding, Grace, Griffin, Hargreaves, Harris, Henley, Hermann, Hermens, Hodge, Isaac, Jaffrey, Jani, Jin, Joslyn, Kalivas, Kapasova, Kapoor, Karkkainen, Karpyak, Kimpel, Klugmann, Kohda, Konno, Koob, Kornau, Kranzler, Kryger, Krystal, Kuo, Kupila, Lallemand, Lappalainen, Laukkainen, Lester, Levey, Lin, Lin, Loh, Lominac, Long, Lum, Lüscher, Maday, Malenka, Malinow, Mardones, Matsumoto, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McBride, McClintick, McCool, Meinhardt, Melendez, Mokdad, Monaghan, Morris, Nevo, Niciu, Obara, Olive, Orth, O’Connor, O’Connor, Patten, Petrakis, Petralia, Preuss, Qrunfleh, Quintero, Rani, Rao, Rao, Reed, Rehm, Rehm, Reich, Reimers, Reissner, Richter, Rietschel, Risher, Rodd, Rodd, Romano, Rothstein, Sala, Sari, Sari, Sari, Sari, Sari, Schnell, Schroeder, Schroeder, Schuckit, Schumann, Selim, Shaw, Sheng, Shigemoto, Shiraishi-Yamaguchi, Spanagel, Staples, Steketee, Swartzwelder, Swartzwelder, Swerdlow, Szumlinski, Szumlinski, Szumlinski, Szumlinski, Tamaru, Tanaka, Tao-Cheng, Tarazi, Terranova, Thoma, Tomita, Traynelis, Van Bockstaele, Vengeliene, Wadiche, Wang, Warburton, Ward, Watterson, Williams, Witzmann, Wong, Worley, Xia, Xiao, Yan, Zamora-Martinez, Zhao, Zhou, Zhou, Ziff   +212 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. [PDF]

, 2014
BackgroundThe age at onset of alcohol dependence (AD) is a critical moderator of genetic associations for alcohol dependence. The present study evaluated whether single nucleotide polymorphisms (SNPs) can influence the age at onset of AD in large high ...
Agrawal, Arpana, Almasy, Laura, Bertelsen, Sarah, Bierut, Laura, Bucholz, Kathleen, Budde, John, Dick, Danielle M, Edenberg, Howard J, Foroud, Tatiana, Goate, Alison, Harari, Oscar, Hesselbrock, Victor, Hinrichs, Anthony L, Kapoor, Manav, Kramer, John, Le, Nhung, Nurnberger, John I, Porjesz, Bernice, Rice, John, Schuckit, Marc, Tischfield, Jay, Wang, Jen-Chyong, Wetherill, Leah, Xiaoling, Xuei   +23 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Cognitive Dysfunctions in Patients with Alcohol Dependence Syndrome in a Tertiary Hospital in Kathmandu

Journal of Nepal Medical Association, 2016
Introduction: Alcohol dependence is a chronic disorder, accompanied by neuropsychological deficits. Patients with alcohol dependence were evaluated to identify the cognitive dysfunctions.
Sirjana Adhikari, Mita Rana, Suraj Shakya, Saroj Prasad Ojha   +3 more
doaj   +3 more sources

A Long-Term Study of Sons of Alcoholics. [PDF]

, 1995
Men with a family history of alcoholism appear to have a lower intensity reaction to alcohol's effects than those without this family history. This study investigated whether a lower reaction could encourage greater alcohol consumption among family ...
Schuckit, Marc A
core  

Genetics of alcohol dependence [PDF]

Psychiatry and Clinical Neurosciences, 2011
Twin, family, and adoption studies have consistently shown that genetic factors play an important role in the pathogenesis of alcohol dependence. Numerous studies have aimed to identify genes that contribute to susceptibility to alcohol dependence. Whole‐genome linkage studies have identified several chromosomal regions that are linked with alcohol ...
Mitsuru, Kimura, Susumu, Higuchi
openaire   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Wareniklina – częściowy agonista receptorów nikotynowych w terapii zespołu uzależnienia od alkoholu

Alcoholism and Drug Addiction, 2016
The pharmacotherapy currently used for alcohol dependence may reduce alcohol consumption and extend abstinence periods. However, it is effective in only about 30% of addicted subjects.
Natalia Obsada, Jadwiga Zalewska-Kaszubska   +1 more
doaj   +1 more source