Results 51 to 60 of about 1,742,228 (306)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Emerging pharmacotherapies for alcohol dependence: a systematic review focusing on reduction in consumption.

, 2013
BACKGROUND: European Medicines Agency guidelines recognize two different treatment goals for alcohol dependence: abstinence and reduction in alcohol consumption. All currently approved agents are indicated for abstinence.
Aubin, H.J., Daeppen, J.B.
core   +1 more source

Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group

Translational Psychiatry, 2021
Males and females with alcohol dependence have distinct mental health and cognitive problems. Animal models of addiction postulate that the underlying neurobiological mechanisms are partially distinct, but there is little evidence of sex differences in ...
Sally Grace, Maria Gloria Rossetti, Nicholas Allen, Albert Batalla, Marcella Bellani, Paolo Brambilla, Yann Chye, Janna Cousijn, Anna E Goudriaan, Robert Hester, Kent Hutchison, Izelle Labuschagne, Reza Momenan, Rocio Martin-Santos, Peter Rendell, Nadia Solowij, Rajita Sinha, Chiang-shan Ray Li, Lianne Schmaal, Zsuzsika Sjoerds, Chao Suo, Gill Terrett, Ruth J. van Holst, Dick J. Veltman, Murat Yücel, Paul Thompson, Patricia Conrod, Scott Mackey, Hugh Garavan, Valentina Lorenzetti   +29 more
doaj   +1 more source

Caregiver burden in alcohol dependence syndrome and its sociodemographic correlates: A cross-sectional study from South India

Kerala Journal of Psychiatry, 2023
Background: Caring for people with severe mental and medical illness adversely affects their natural caregivers, which is measured as caregiver burden (CGB).
Jithin T Joseph, V R Aniji , V Arun, Mathew J Valamparampil   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Studies of Alcohol: Past, Present and Future

, 1989
Copy of the article Mendelson, J. H., & Mello, N. K. (1989). Studies of Alcohol: Past, Present and Future. Journal of Studies on Alcohol, 50(4), 293–196.
Mendelson, Jack, H., Mello, Nancy, K.
core   +1 more source

A Prospective Comparison of Bipolar I and II Subjects With and Without Comorbid Alcohol Dependence From the COGA Dataset

Frontiers in Psychiatry, 2020
Objective: Comorbidity of alcohol use disorders in bipolar subjects is high as indicated by epidemiological and clinical studies. Though a more severe course of bipolar disorder in subjects with comorbid alcohol dependence has been reported, fewer ...
Ulrich W. Preuss, Ulrich W. Preuss, M. N. Hesselbrock, V. M. Hesselbrock   +3 more
doaj   +1 more source

Men with and without alcohol dependence: A comparative study of Triguna, nonattachment, personality and subjective well-being

International Journal of Yoga, 2022
Context: Indian models of personality are seldom explored in relation to alcohol dependence. Triguna is an Indian model of personality originating from the Sankhya philosophy, whereby three gunas, Sattva, Rajas and Tamas describe personality features ...
Chandana Nedungottil, Jyotsna Agrawal, Mahendra Prakash Sharma, Pratima Murthy   +3 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source