Results 61 to 70 of about 546,315 (303)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Cognitive functions in alcohol use and cannabis use disorder: A cross-sectional study

Journal of Mental Health and Human Behaviour, 2019
Background and Aim: Alcohol and cannabis misuse have an impact on neurocognition. This cross-sectional study evaluated the neuropsychological performance of individuals with alcohol dependence and cannabis dependence with concomitant alcohol use ...
Ottilingam Somasundaram Ravindran, G Nandini, Natarajan Shanmugasundaram, V Vivian Kapil   +3 more
doaj   +1 more source

Men with and without alcohol dependence: A comparative study of Triguna, nonattachment, personality and subjective well-being

International Journal of Yoga, 2022
Context: Indian models of personality are seldom explored in relation to alcohol dependence. Triguna is an Indian model of personality originating from the Sankhya philosophy, whereby three gunas, Sattva, Rajas and Tamas describe personality features ...
Chandana Nedungottil, Jyotsna Agrawal, Mahendra Prakash Sharma, Pratima Murthy   +3 more
doaj   +1 more source

Performance of a Brief Assessment Tool for Identifying Substance Use Disorders [PDF]

, 2003
Objective: Evaluation of the performance of a brief assessment tool for identifying substance use disorders. The Triage Assessment for Addictive Disorders (TAAD) is a triage instrument that provides professionals with a tool to evaluate indications of ...
Campbell, Todd, Hoffman, Norman G, Madson, Michael B, Melchert, Timothy   +3 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

A Prospective Comparison of Bipolar I and II Subjects With and Without Comorbid Alcohol Dependence From the COGA Dataset

Frontiers in Psychiatry, 2020
Objective: Comorbidity of alcohol use disorders in bipolar subjects is high as indicated by epidemiological and clinical studies. Though a more severe course of bipolar disorder in subjects with comorbid alcohol dependence has been reported, fewer ...
Ulrich W. Preuss, Ulrich W. Preuss, M. N. Hesselbrock, V. M. Hesselbrock   +3 more
doaj   +1 more source

Neurofilament Light Chain Is a Promising Biomarker in Alcohol Dependence

Frontiers in Psychiatry, 2021
Background: Alcohol dependence, a global public health problem, leads to structural and functional damage in the brain. Alcohol dependence patients present complex and varied clinical manifestations and live with general complaints existing in ...
Yanfei Li, Ranran Duan, Zhe Gong, Lijun Jing, Tian Zhang, Yong Zhang, Yanjie Jia   +6 more
doaj   +1 more source

Gabapentin in Alcohol Dependence [PDF]

Journal of Pharmacy Technology, 2015
Objective: To review the literature related to the use of gabapentin in alcohol dependence following acute alcohol withdrawal. Data Sources: Searches of MEDLINE (1946-January 2015) and Cochrane Database (2005-January 2015) were performed using gabapentin, alcohol, and alcoholism as MeSH terms and keywords.
Morgan D, Greutman, Mark A, Gales, Barry J, Gales   +2 more
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence [PDF]

, 2013
Previous findings have demonstrated that variants in nicotinic receptor genes are associated with nicotine, alcohol and cocaine dependence. Because of the substantial comorbidity, it has often been unclear whether a variant is associated with multiple ...
Agrawal, Arpana, Almasy, Laura, Bierut, Laura, Brooks, Andy, Bucholz, Kathleen, Budde, John, Edenberg, Howard, Goate, Alison, Haller, Gabe, Kapoor, Manav, Kramer, John, Nurnberger, John, Rice, John, Saccone, Nancy, Tischfield, Jay, Xuei, Xiaoling   +15 more
core   +1 more source