Results 41 to 50 of about 198,403 (311)

Correlations between sex-related hormones, alcohol dependence and alcohol craving

, 2019
Background: Sex-related differences in the susceptibility, progression, and treatment response in alcohol-dependent subjects have been repeatedly reported.
Winham, Stacey J., Ho, Ada M-C,, Ho, Ada M-C, Karpyak, Victor M.,, Winham, Stacey J.,, Geske, Jennifer R., Bakalkin, Georgy,, Bakalkin, Georgy, Karpyak, Victor M., Geske, Jennifer R.,   +9 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pharmacogenetics of Alcohol and Alcohol Dependence Treatment [PDF]

Current Pharmaceutical Design, 2010
In this article, we review studies of genetic moderators of the response to medications to treat alcohol dependence, the acute response to alcohol, and the response to the psychotherapeutic treatment of heavy drinking. We consider four neurotransmitter systems: opioidergic, dopaminergic, GABAergic, and glutamatergic and focus on one receptor protein in
Henry R, Kranzler, Howard J, Edenberg
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Correlation analysis between clinical effective emotional treatment and plasma N-methyl-D-aspartate receptor function-related indexes

Frontiers in Neuroscience
BackgroundWith the use of ketamine, Glutamate (Glu) system has gradually become the focus of antidepressant effects. N-methyl-D-aspartate receptor (NMDAR), as one of the major ionic glutamate receptors, plays a dominant role in antidepressant effects ...
Zuxing Feng, Yanli Li, Ying Cai, Fan Yang, Fan Yang, Xiangfeng Zhou, Maoyang Feng, Li Wu   +7 more
doaj   +1 more source

Czynniki ryzyka podejmowania prób samobójczych u osób leczonych stacjonarnie z powodu uzależnienia od alkoholu w Polsce

Alcoholism and Drug Addiction, 2015
Introduction: Alcohol dependence is an important risk factor for suicidal behaviours. Current data show that between 14 and 43% of alcohol-dependent patients attempt suicide.
Aneta Michalska, Maciej Kopera, Bartłomiej Gmaj, Agata Łoczewska, Natalia Szejko, Eliza Kisielińska, Marcin Wojnar   +6 more
doaj   +1 more source

Emerging pharmacotherapies for alcohol dependence: a systematic review focusing on reduction in consumption.

, 2013
BACKGROUND: European Medicines Agency guidelines recognize two different treatment goals for alcohol dependence: abstinence and reduction in alcohol consumption. All currently approved agents are indicated for abstinence.
Aubin, H.J., Daeppen, J.B.
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Czynniki ryzyka majaczenia alkoholowego u osób leczonych stacjonarnie w Polsce z powodu uzależnienia od alkoholu

Alcoholism and Drug Addiction, 2016
Introduction: Delirium tremens (DT) is a life-threatening complication that occurs in 5–33% of patients treated for alcohol withdrawal syndrome. The aim of the present study was to analyse the risk factors for delirium tremens among patients treated for ...
Aneta Michalska, Maciej Kopera, Bartłomiej Gmaj, Agata Łoczewska, Natalia Szejko, Dorota Wołyńczyk-Gmaj, Eliza Kisielińska, Sylwia Fudalej, Marcin Wojnar   +8 more
doaj   +1 more source

Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group

Translational Psychiatry, 2021
Males and females with alcohol dependence have distinct mental health and cognitive problems. Animal models of addiction postulate that the underlying neurobiological mechanisms are partially distinct, but there is little evidence of sex differences in ...
Sally Grace, Maria Gloria Rossetti, Nicholas Allen, Albert Batalla, Marcella Bellani, Paolo Brambilla, Yann Chye, Janna Cousijn, Anna E Goudriaan, Robert Hester, Kent Hutchison, Izelle Labuschagne, Reza Momenan, Rocio Martin-Santos, Peter Rendell, Nadia Solowij, Rajita Sinha, Chiang-shan Ray Li, Lianne Schmaal, Zsuzsika Sjoerds, Chao Suo, Gill Terrett, Ruth J. van Holst, Dick J. Veltman, Murat Yücel, Paul Thompson, Patricia Conrod, Scott Mackey, Hugh Garavan, Valentina Lorenzetti   +29 more
doaj   +1 more source