Results 21 to 30 of about 173,083 (258)

Cue reactivity is associated with duration and severity of alcohol dependence: an FMRI study. [PDF]

PLoS ONE, 2014
INTRODUCTION: With the progression of substance dependence, drug cue-related brain activation is thought to shift from motivational towards habit pathways. However, a direct association between cue-induced brain activation and dependence duration has not
Zsuzsika Sjoerds, Wim van den Brink, Aartjan T F Beekman, Brenda W J H Penninx, Dick J Veltman   +4 more
doaj   +1 more source

Cannabis use and dependence among French schizophrenic inpatients

Frontiers in Psychiatry, 2014
Background: To assess the prevalence of cannabis use and dependence in a population of schizophrenic inpatients and to compare schizophrenics with and without cannabis consumption. Methods: 101 schizophrenic patients were examined during their first week
Michel eLejoyeux
doaj   +1 more source

Clinical factors associated with relapse in male alcohol dependents during six-month follow-up

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Aim of this study was to evaluate the clinical factors associated with relapse to alcohol use during sixmonth after inpatient treatment in male alcohol dependents. Method: Participants were 156 consecutively admitted male alcohol dependents.
Cuneyt Evren, Rabia Cetin, Mine Durkaya, Ercan Dalbudak   +3 more
doaj  

Alcohol dependence syndrome in patients with alcoholic liver disease: A cross sectional observational study

Industrial Psychiatry Journal, 2023
Background: Excessive alcohol use leads to a spectrum of liver disease. While physicians treat liver disease, the cause, i.e. alcohol, often remains untreated.
CS Bharath, Kaushik Chatterjee, Arun S. Yadav, Ankit Dangi, Pookala Shivaram Bhat   +4 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

The prevalence of alcohol dependence and its association with hypertension: a population-based cross-sectional study4 in Xuzhou city, China

BMC Public Health, 2018
Background To describe the prevalence of alcohol dependence and to explore the relationship between alcohol dependence and newly detected hypertension in China.
Ailing Ji, Peian Lou, Zongmei Dong, Chunrong Xu, Pan Zhang, Guiqiu Chang, Ting Li   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Correlation analysis between clinical effective emotional treatment and plasma N-methyl-D-aspartate receptor function-related indexes

Frontiers in Neuroscience
BackgroundWith the use of ketamine, Glutamate (Glu) system has gradually become the focus of antidepressant effects. N-methyl-D-aspartate receptor (NMDAR), as one of the major ionic glutamate receptors, plays a dominant role in antidepressant effects ...
Zuxing Feng, Yanli Li, Ying Cai, Fan Yang, Fan Yang, Xiangfeng Zhou, Maoyang Feng, Li Wu   +7 more
doaj   +1 more source

Czynniki ryzyka podejmowania prób samobójczych u osób leczonych stacjonarnie z powodu uzależnienia od alkoholu w Polsce

Alcoholism and Drug Addiction, 2015
Introduction: Alcohol dependence is an important risk factor for suicidal behaviours. Current data show that between 14 and 43% of alcohol-dependent patients attempt suicide.
Aneta Michalska, Maciej Kopera, Bartłomiej Gmaj, Agata Łoczewska, Natalia Szejko, Eliza Kisielińska, Marcin Wojnar   +6 more
doaj   +1 more source