Results 91 to 100 of about 2,727,544 (257)

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Exploring language production, comprehension and naming in adolescents with fetal alcohol spectrum disorders [PDF]

, 2011
The aims of this study were i) to evaluate the domains of language production, comprehension and naming in children with moderate or heavy prenatal exposure to alcohol, and ii) to determine if these domains are a specific weakness in these children.
Corbett, Claire
core   +1 more source

Towards ICD-11 for alcohol dependence: Diagnostic agreement with ICD-10, DSM-5, DSM-IV, DSM-III-R and DSM-III diagnoses in a Swedish general population of women

, 2021
Background: The proposed ICD-11 classification includes major revisions of alcohol dependence. We aimed to evaluate the presence of, and concordance between the proposed ICD-11 dependence and ICD-10, DSM-5, DSM-IV, DSM-III-R and DSM-III in a general ...
Lundin, A., Love, J, Lundin, A,, Waern, M, Danielsson, A-K, Lövestad, Solveig,, Hensing, Gunnel,, Lovestad, S, Hensing, G, Waern, Margda,, Löve, Jesper,, Danielsson, A-K,   +11 more
core   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

Clinical Correlates of Impulsivity, Depression, and Quality of Life in Alcohol and Opioid Dependence: A Comparative Study [PDF]

Indian Journal of Private Psychiatry
Background: Alcohol is one of the most prevalent substances used in India, followed by opioids. Dependence on these substances not only affects physical health but also an individual’s behavior, mood, and quality of life (QoL). Aim: To assess and compare
Jitendra Jeenger, Rohan Modi, Divya D Modi, Manu Sharma   +3 more
doaj   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Concordance of diagnoses between International Classification of Diseases (ICD) 11th and 10th revisions for alcohol dependence and harmful use and its implications for psychiatric care

Industrial Psychiatry Journal
Background: WHO has revised International Classification of Diseases (ICD) to 11th edition. There are some important changes in description of the diseases. Transition is expected to throw some challenges.
Virendra V. Singh, Bikram K. Dutta, Surender Sharma, Raghu N. Mani, Anindya K. Gupta   +4 more
doaj   +1 more source

Foetal alcohol syndrome: a case report from Sri Lanka

Sri Lanka Journal of Psychiatry, 2013
Alcohol dependence is not a major health problem among females in Sri Lanka unlike in males. Hence the adverse effects unique to alcohol consumption in females are uncommon.
Chathurie Suraweera, Raveen Hanwella
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source