Results 81 to 90 of about 205,440 (310)

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

Advanced Science, EarlyView.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu, Haowen Jiang, Yichang Liu, Chang Peng, Hanlin Wang, Wenhua Yang, Zan Lyu, Yan Sun, Huan Ma, Hongyu Gu, Weijuan Kan, Liya Jing, Tiancheng Dong, Chunmei Xia, Saifei Lei, Rui Wu, Jinlong Li, Jia Li   +17 more
wiley   +1 more source

Doctors' drinking habits and consumption of alcohol. [PDF]

, 1988
Juhani Juntunen, Sisko Asp, M Olkinuora, M. Äärimaa, L. Strid, Kyllikki Kauttu   +5 more
openalex   +1 more source

MicroRNA‐Enriched Plant‐Derived Exosomes Alleviate Colitis by Modulating Systemic Immunity, Metabolic Homeostasis, and Gut Microbiota

Advanced Science, EarlyView.
Herbal medicine, with its multicomponent and multitarget potential, is often studied primarily for traditional forms, especially phytochemicals. Currently, ulcerative colitis lacks natural, low‐toxicity therapies, yet emerging research highlights plant‐derived exosomes as a promising option.
Ruipeng Shi, Wen Tan, Haochun Jin, Sio I Chan, Wei Li, Si San Lei, Guozhen Cui, Yitao Wang, Dong‐Hua Yang, Zhangfeng Zhong   +9 more
wiley   +1 more source

Parental supply of alcohol and adolescent drinking: a multilevel analysis of nationally representative data

BMC Public Health, 2017
Background Existing research on parental supply of alcohol analyses the effects of self-reported parental supply on adolescent drinking using individual level data.
Gary C. K. Chan, Janni Leung, Jason Connor, Wayne Hall, Adrian B. Kelly   +4 more
doaj   +1 more source

A six year longitudinal study of the occupational consequences of drinking over "safe limits" of alcohol. [PDF]

, 1992
Rachel Jenkins, S. Marie Harvey, Tony Butler, Roger L. Thomas   +3 more
openalex   +1 more source

THE PRIZE ESSAY ON ALCOHOLIC DRINKS. [PDF]

The Lancet
n ...
Beggs, Thomas, Gilpin, Charles
openaire   +2 more sources

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff   +17 more
wiley   +1 more source

Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system

Cell Reports
Summary: High-intensity alcohol drinking during binge episodes contributes to the socioeconomic burden created by alcohol use disorders (AUDs), and nociceptin receptor (NOP) antagonists have emerged as a promising intervention.
Harold Haun, Raul Hernandez, Luzi Yan, Meghan Flanigan, Olivia Hon, Sophia Lee, Hernán Méndez, Alison Roland, Lisa Taxier, Thomas Kash   +9 more
doaj   +1 more source

Disruption of Gut Microbiota‐Mediated De Novo NAD+ Synthesis Contributes to the Development of Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This study demonstrates that patients with PCOS exhibit altered gut microbial profiles, and FMT from PCOS patients induces PCOS‐like symptoms in mice. Specifically, gut dysbiosis reduces 3‐HAA levels in the context of PCOS. Administration of 3‐HAA to mice alleviates PCOS by promoting de novo NAD+ synthesis.
Ke Chen, Huafeng Geng, Yang Zheng, Hongyang Xie, Rui Qin, Junyang Chen, Cong Ye   +6 more
wiley   +1 more source

Harmful alcohol drinking among HIV-positive people in Nepal: an overlooked threat to anti-retroviral therapy adherence and health-related quality of life

Global Health Action, 2018
Background: People living with Human Immunodeficiency Virus (HIV) often suffer from alcohol-use disorders resulting in their poor health and treatment outcomes.
Khem Narayan Pokhrel, Kalpana Gaulee Pokhrel, Sanjeev Raj Neupane, Vidya Dev Sharma   +3 more
doaj   +1 more source