Results 151 to 160 of about 940,087 (264)

Morin Attenuates Diclofenac‐Induced Hepatocellular Death Injury via Nrf2/Ho‐1/NQO1, Beclin‐1/LC3A/LC3B and p53/Bax/Caspase Signalling Pathways

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 39, Issue 7, July 2025.
ABSTRACT Diclofenac (DF), a nonsteroidal and anti‐inflammatory drug, has limited use due to its adverse effects on the liver. On the other hand, morin, a bioflavonoid, has biological and pharmacological properties. This study aims to investigate whether morin may protect against diclofenac‐induced liver toxicity.
Nurhan Akaras   +5 more
wiley   +1 more source

Mitochondria‐Associated Endoplasmic Reticulum Membranes in Human Health and Diseases

open access: yesMedComm, Volume 6, Issue 7, July 2025.
MAM dysfunction is considered as an initiator or contributor in the progression of various diseases such as nervous system diseases, circulatory system diseases, digestive system diseases, locomotor system diseases, reproductive system diseases, endocrine system diseases, urinary system diseases, respiratory system diseases and cancer.
Yong Liu   +10 more
wiley   +1 more source

Oxidative Stress: Signaling Pathways, Biological Functions, and Disease

open access: yesMedComm, Volume 6, Issue 7, July 2025.
Oxidative stress causes cellular damage across multiple systems, contributing to neurodegeneration (Alzheimer's, Parkinson's, Huntington's), cancer progression and resistance, cardiovascular diseases (atherosclerosis, heart failure), liver and kidney injury, metabolic disorders (diabetes, obesity), autoimmune diseases, musculoskeletal decline, retinal ...
Sixuan Liu   +4 more
wiley   +1 more source

OsPRK1/2/3‐mediated reactive oxygen species signaling is required for pollen tube germination in rice

open access: yesJournal of Integrative Plant Biology, Volume 67, Issue 7, Page 1965-1981, July 2025.
The rice pollen‐specific receptor‐like kinases OsPRK1, OsPRK2, and OsPRK3 play a crucial role in reactive oxygen species (ROS)‐mediated pollen hydration and germination. Triple mutants display male sterility due to decreased ROS levels and impaired pollen hydration, and their germination phenotype can be partially restored by exogenous application of ...
Eui‐Jung Kim   +9 more
wiley   +1 more source

The gut‐microbiota‐brain axis: Focus on gut steroids

open access: yesJournal of Neuroendocrinology, Volume 37, Issue 7, July 2025.
Abstract There are over 1000 varieties of steroids that have been reported in nature, including the endogenous sex steroid hormones (i.e., progesterone, testosterone, and 17β‐estradiol) and corticosteroids which are mainly synthesized by gonads and adrenals, respectively.
Silvia Diviccaro   +4 more
wiley   +1 more source

E3‐Ubiquitin Ligase SgATL31 Promotes Anthracnose Resistance in Stylosanthes by Modulating ROS Burst and Antioxidant Defence: A Proteomic and Functional Study

open access: yesMolecular Plant Pathology, Volume 26, Issue 7, July 2025.
Integrated proteomics revealed anthracnose resistance factors in Stylosanthes, identifying the E3 ligase SgATL31 as a positive regulator through ROS and antioxidant pathway modulation. ABSTRACT Stylosanthes spp. (stylo) is an important leguminous forage cultivated in tropical areas.
Liyun Yang   +6 more
wiley   +1 more source

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

open access: yesThe FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source

Genetic variation in metronidazole metabolism and oxidative stress pathways in clinical Giardia lamblia assemblage A and B isolates

open access: yesInfection and Drug Resistance, 2019
Christina S Saghaug,1,2 Christian Klotz,3 Juha P Kallio,4 Hans-Richard Brattbakk,1,5 Tomasz Stokowy,1,5 Toni Aebischer,3 Inari Kursula,4,6 Nina Langeland,1–2,7 Kurt Hanevik1,21Department of Clinical Science, University of Bergen, Bergen, Hordaland,
Saghaug CS   +8 more
doaj  

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