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Microbial Alcohol/Aldehyde Oxidoreductases in Enantioselective Conversions

, 1992
Microbes have an enormous diversity of alcohol and aldehyde oxidoreductases. A brief overview is given of the types known and of some novel ones discovered recently. Except from the classical, NAD-dependent, alcohol dehydrogenase (the long chain, zinc-containing type, EC 1.1.1.1), these enzymes are unexplored with respect to enantioselectivity.
Arie Geerlof, J. Bert A. Van Tol, J. A. Jongejan, Johannis A. Duine   +3 more
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Alcohol, lactate and glutamate sensors based on oxidoreductases with regeneration of nicotinamide adenine dinucleotide

Analytica Chimica Acta, 1978
Flowthrough enzyme electrodes are reported for determinations of alcohol, lactate and glutamate. Oxidoreductases mixed with immobilized NAD+ cofactor are held between a suitable platinum electrode and a semipermeable membrane. The coenzyme is readily regenerated either directly by electrochemical oxidation or by using phenazine methosulphate (PMS+) as ...
Albertas Malinauskas, Juozas Kulys
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Genetics and differential expression of NADH:ubiquinone oxidoreductase B8 subunit in brains of genetic strains of mice differing in voluntary alcohol consumption

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002
Inbred strains of mice remain a valuable resource for genetic dissection of complex traits including responses to drugs and chemicals, particularly alcohol. As a novel source of candidate genes for further analysis, we have used mRNA differential displays to identify genes with differential expression in the brains of ethanol-preferring (C57BL/6J) vs ...
Michelle Harrison, Shiva M. Singh
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ChlOR, a GMC family oxidoreductase that evolved independently from the actinomycete, confers resistance to amphenicol antibiotics.

Environmental Microbiology, 2023
Overuse of the amphenicol antibiotics chloramphenicol (CHL) and thiamphenicol (TAP) poses a great threat to ecosystem safety and human health. The strain, Nocardioides sp. LMS-CY, Nocardioides sp. QY071 and Nocardioides sp.
Yingying Qian, Minggen Cheng, Linshiyu Lai, J. Zhou, G. Zylstra, Xing Huang   +5 more
semanticscholar   +1 more source

Electroenzymatic Reduction of Furfural to Furfuryl Alcohol by an Electron Mediator and Enzyme Orderly Assembled Biocathode.

ACS Applied Materials and Interfaces, 2023
The electroenzymatic valorization of biomass derivatives into valuable biochemicals has a promising outlook. However, bottlenecks including poor electron transfer between the electrode surface and oxidoreductase, inefficient regeneration of cofactors ...
P. Zhan, Xiangshi Liu, Shiding Zhang, Qian Zhu, Hongqing Zhao, Cong Ren, Jiawen Zhang, Lu Lu, Di Cai, Peiyong Qin   +9 more
semanticscholar   +1 more source

Substrate specificity of citrus alcohol: NAD oxidoreductase

Journal of Agricultural and Food Chemistry, 1971
J.H. Bruemmer, BONGWOO ROE
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Aged Garlic Extract Prevents Alcohol-Induced Cytotoxicity through Induction of Aldehyde Dehydrogenase 2 in the Liver of Mice.

Molecular Nutrition & Food Research, 2023
SCOPE Acetaldehyde is a highly toxic primary metabolite of ethanol, and converted to non-toxic acetic acid by aldehyde dehydrogenase (ALDH). Accumulation of acetaldehyde causes significant damage to our body.
T. Kitakaze, M. Inoue, H. Ashida
semanticscholar   +1 more source

Normal mode analysis and comparative study of intrinsic dynamics of alcohol oxidase enzymes from GMC protein family

Journal of Biomolecular Structure and Dynamics, 2023
Glucose-Methanol-Choline (GMC) family enzymes are very important in catalyzing the oxidation of a wide range of structurally diverse substrates. Enzymes that constitute the GMC family, share a common tertiary fold but < 25% sequence identity.
Mohammad Wahab Khan, A. Murali
semanticscholar   +1 more source

[Protective effects of Polygonatum odoratum polysaccharides on alcohol-induced injury of HepG2 cells and its mechanisms].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2022
Objective: To investigate the protective effects of Polygonatum odoratum polysaccharides (POP) on alcohol-induced injury of HepG2 cells and its potential molecular mechanisms.
Qiliong Zhu, Ya-Wen Wu, Xiao-hui Wang, Geng-Xi Li   +3 more
semanticscholar   +1 more source

MiR-214 promotes the alcohol-induced oxidative stress via down-regulation of glutathione reductase and cytochrome P450 oxidoreductase in liver cells.

Alcoholism: Clinical and Experimental Research, 2014
BACKGROUND The involvement of oxidative stress in the pathophysiological process of alcohol-induced liver injury has been studied for decades. However, the role of microRNAs (miRNAs) targeting to oxidative stress genes in the pathogenesis of alcohol ...
Xiaolong Dong, Hong Liu, Fangjie Chen, Dejun Li, Yanyan Zhao   +4 more
semanticscholar   +1 more source