Results 141 to 150 of about 943,763 (288)

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang, Shaoqing Yu, Wenjie Wei, Wen Tao, Tianwei Cai, Lequan Wen, Jiali Ye, Chi Zhang, Huayi Feng, Senming Cao, Baojun Wang, Xin Ma, Yan Huang, Xu Zhang   +13 more
wiley   +1 more source

Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Overview of Sructure, Multienzyme‐mimicking Activity and Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase. Abstract Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis.
Kai Song, Yu Wei, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu   +9 more
wiley   +1 more source

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu, Congcong Jiang, Hian Kee Lee, Yuanjian Zhang, Sheng Tang   +4 more
wiley   +1 more source

Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review

BioFactors, Volume 52, Issue 1, January/February 2026.
Resveratrol induces the expressions of TP53, NRF2, and JDP2 axis in cancer cells to control ROS balance in mitochondria. The antioxidation responses were induced through SRIT1/3, HDAC, STAT3, TGFβ, and so on, to trigger the inflammation, and NFkB response to lead to the cell death of cancers or neuro‐damaged cells.
Kenly Wuputra, Chia‐Che Ku, Ying‐Chu Lin, Yi‐Chun Tsai, Deng‐Chyang Wu, Yukio Mitsui, Maki Satou, Yuuki Tanaka, Shigeo Saito, Kazunari K. Yokoyama   +9 more
wiley   +1 more source

Sjögren-Larsson syndrome. Impaired fatty alcohol oxidation in cultured fibroblasts due to deficient fatty alcohol:nicotinamide adenine dinucleotide oxidoreductase activity. [PDF]

, 1988
William B. Rizzo, Andrea L. Dammann, Debra A. Craft   +2 more
openalex   +1 more source

New oxidoreductases from cyanobacteria for asymmetric synthesis of chiral alcohols

New Biotechnology, 2009
K. Hölsch, D. Weuster-Botz
openaire   +1 more source

A Meta‐Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data

Brain and Behavior, Volume 16, Issue 1, January 2026.
Chronic stress is linked to many human psychiatric disorders involving the prefrontal cortex (PFC). We performed a meta‐analysis of public transcriptional profiling data that showed that chronically stressed mice have less gene expression for glia and neural activity in the PFC. These findings mirror patterns seen in psychiatric patients.
Jinglin Xiong, Megan H. Hagenauer, Cosette A. Rhoads, Elizabeth Flandreau, Nancy Rempel‐Clower, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Toni Duan, Stanley Watson Jr., Huda Akil   +10 more
wiley   +1 more source

Bioreduction of β‐ketosulfides Using Deep Eutectic Solvents as Cosolvents

ChemCatChem, Volume 18, Issue 2, 28 January 2026.
A set of β‐ketosulfides has been selectively reduced to optically active β‐hydroxysulfides employing KREDs as biocatalysts in the presence of Deep Eutectic Solvents. By appropriately selecting both the biocatalyst and the reaction medium, both alcohol enantiomers can be obtained in high yields and optical purities.
Chiara Falcini, Juan Carvajal‐Bárcena, Lucía V. Urban, Juan Pablo Colomer, Fabricio R. Bisogno, Rosario Fernández, Gonzalo de Gonzalo   +6 more
wiley   +1 more source

Construction and Screening of Metagenomic Libraries Derived from Enrichment Cultures: Generation of a Gene Bank for Genes Conferring Alcohol Oxidoreductase Activity on Escherichia coli

, 2003
Anja Knietsch, Tanja Waschkowitz, Susanne Bowien, Anke Henne, Rolf Daniel   +4 more
openalex   +1 more source

A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases.

ACS Synthetic Biology, 2017
Jackson K. B. Cahn, Caroline A. Werlang, Armin Baumschlager, S. Brinkmann-Chen, S. L. Mayo, F. Arnold   +5 more
semanticscholar   +1 more source