Results 31 to 40 of about 10,574 (182)

Systematic metadata analysis of brown rot fungi gene expression data reveals the genes involved in Fenton’s reaction and wood decay process

Mycology, 2020
Brown-rot fungi are rapid holocellulose degraders and are the most predominant degraders of coniferous wood products in North America. Brown-rot fungi degrades wood by both enzymatic (plant biomass degrading carbohydrate active enzymes-CAZymes) and non ...
Ayyappa Kumar Sista Kameshwar, Wensheng Qin   +1 more
doaj   +1 more source

Oxidoreductases and Hydroxynitrilase Lyases: Complementary Enzymatic Technologies for Chiral Alcohols

Engineering in Life Sciences, 2006
AbstractBiocatalytic processes are useful methods for the production of chiral intermediates. As an example, alcohol dehydrogenases are applied for the production of chiral alcohols by asymmetric reduction of prochiral ketones. From this class of enzymes alcohol dehydrogenase from Lactobacillus brevis will be described with respect to its industrial ...
T. Daußmann, T. C. Rosen, P. Dünkelmann   +2 more
openaire   +1 more source

Sortase A-mediated crosslinked short-chain dehydrogenases/reductases as novel biocatalysts with improved thermostability and catalytic efficiency

Scientific Reports, 2017
(S)-carbonyl reductase II (SCRII) from Candida parapsilosis is a short-chain alcohol dehydrogenase/reductase. It catalyses the conversion of 2-hydroxyacetophenone to (S)-1-phenyl-1,2-ethanediol with low efficiency.
Kunpeng Li, Rongzhen Zhang, Yan Xu, Zhimeng Wu, Jing Li, Xiaotian Zhou, Jiawei Jiang, Haiyan Liu, Rong Xiao   +8 more
doaj   +1 more source

Genome and secretome of Chondrostereum purpureum correspond to saprotrophic and phytopathogenic life styles.

PLoS ONE, 2019
The basidiomycete Chondrostereum purpureum (Silverleaf fungus) is a saprotroph and plant pathogen commercially used for combatting forest "weed" trees in vegetation management.
Rocio Reina, Harald Kellner, Jaqueline Hess, Nico Jehmlich, Immaculada García-Romera, Elisabet Aranda, Martin Hofrichter, Christiane Liers   +7 more
doaj   +1 more source

Substrate specificity mapping of fungal CAZy AA3_2 oxidoreductases

Biotechnology for Biofuels and Bioproducts
Background Oxidative enzymes targeting lignocellulosic substrates are presently classified into various auxiliary activity (AA) families within the carbohydrate-active enzyme (CAZy) database.
Hongbo Zhao, Johanna Karppi, Owen Mototsune, Daria Poshina, Jenny Svartström, Thi Truc Minh Nguyen, Tri Minh Vo, Adrian Tsang, Emma Master, Maija Tenkanen   +9 more
doaj   +1 more source

Dynamic exchange strategy for enzyme immobilization in Zr-based metal-organic frameworks for green synthesis of β-lactam antibiotics

Green Chemical Engineering
Penicillin G acylase (PGA), a crucial biocatalyst in β-lactam antibiotic synthesis, has been significantly limited in its industrial application due to inherent stability issues. To address this critical challenge, efficient immobilization strategies and
Heng Hu, Shaochun Wu, Yunlong Zheng, Zhenjie Zhang, Mingfang Yang, Yao Chen   +5 more
doaj   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Substrate diffusion and oxidation in GMC oxidoreductases: an experimental and computational study on fungal aryl-alcohol oxidase

Biochemical Journal, 2011
AAO (aryl-alcohol oxidase) provides H2O2 in fungal degradation of lignin, a process of high biotechnological interest. The crystal structure of AAO does not show open access to the active site, where different aromatic alcohols are oxidized. In the present study we investigated substrate diffusion and oxidation in AAO compared with the structurally ...
Hernández-Ortega A, Borrelli K, Ferreira P, Medina M, Martínez AT, Guallar V   +5 more
openaire   +4 more sources