Results 61 to 70 of about 877,912 (228)

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

The septal reduction severity and outcomes after alcohol septal ablation in patients with obstructive hypertrophic cardiomyopathy

Вестник хирургии имени И.И. Грекова
INTRODUCTION. This study examines the impact of the degree of interventricular septum reduction (<5 mm and ≥5 mm) on outcomes following alcohol septal ablation.METHODS AND MATERIALS.
E. A. Shloydo, M. G. Kashtanov, K. V. Popov, A. S. Sergeev, D. S. Maznev, S. D. Chernyshev   +5 more
doaj   +1 more source

Surgical Myectomy after Failed Ablation for Hypertrophic Obstructive Cardiomyopathy

The Thoracic & Cardiovascular Surgeon Reports, 2016
Background Hypertrophic cardiomyopathy is a genetic disease of the myocardial sarcolemma characterized by left ventricular hypertrophy. When obstruction to the left ventricular outflow tract is present and symptoms are refractory to medication, surgical ...
Ioannis Bougioukas, Uta Hoppe, Bernhard Danner, Friedrich A. Schoendube   +3 more
doaj   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Is subcutaneous fat tissue embolization effective and safe as a septal reduction technique in a patient with hypertrophic obstructive cardiomyopathy?

Türk Kardiyoloji Derneği Arşivi, 2018
Hypertrophic obstructive cardiomyopathy is an inheritable cardiac disease that typically manifests with an increased left ventricular outflow tract gradient.
Elnur Alizade, Sabahattin Gündüz, Ahmet Güner, Khagani Isgandarov, Selçuk Pala   +4 more
doaj   +1 more source

Alcohol septal ablation for obstructive hypertrophic cardiomyopathy

European Cardiology Review, 2007
Hypertrophic cardiomyopathy (HCM) is a genetic disease occurring in approximately one in 500–1000 of the general population. HCM is often undiagnosed or misdiagnosed, and asymptomatic cases are often unrecognized. Asymmetric left ventricular (LV) hypertrophy (LVH) most often develops during the period of rapid body growth of adolescence, but it may be ...
Saidi Mohiddin, Charles Knight
openaire   +1 more source

A repeat alcohol septal ablation procedure for hypertrophic obstructive cardiomyopathy where the first septal branch arose from the intermediate (Ramus) artery

, 2013
Septal reduction therapy (via alcohol septal ablation or surgical myomectomy) is indicated in patients with hyper- trophic obstructive cardiomyopathy (HOCM) who have NYHA class III/IV symptoms despite maximal medical therapy. In 90% of patients with HOCM
Doran, Grainne C., Burns, Catherine M., Incani, Alexander, Murdoch, Dale J., Walters, Darren L.   +4 more
core   +1 more source

Chemically Modular, Nonfluorinated Polymer Adsorbents for Capturing Per‐ and Polyfluoroalkyl Substances (PFAS)

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Nonfluorinated polymer networks for PFAS adsorption are synthesized using active ester click chemistry. Incorporating Lewis base ligands along with hydrophilic and hydrophobic co‐monomers leads to high PFOA binding efficiency. Ligand basicity and pH are found to play an important role in PFOA sorption.
Lakshay K. Dhamania, Joshua D. Moon
wiley   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source