Results 201 to 210 of about 2,165,233 (395)

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq   +4 more
wiley   +1 more source

Insulin signal transduction mediates ethanol-induced feeding dysfunction in a fly model of Fetal Alcohol Spectrum Disorder [PDF]

open access: yes, 2019
Fetal alcohol spectrum disorder (FASD) is the leading cause of congenital intellectual disabilities in the Western World, with a worldwide prevalence of 2-11% of all births.
Matsubara, Manae
core   +1 more source

Validation of the Alcohol Use Questionnaire (AUQ) in the Italian Context: A Measure for Assessing Alcohol Intake and Binge Drinking

open access: yesEuropean Journal of Investigation in Health, Psychology and Education
An accurate assessment of alcohol consumption is essential for identifying at-risk individuals and informing prevention and intervention strategies. The present study aimed to validate the Italian version of the Alcohol Use Questionnaire (AUQ), a self ...
Eleonora Topino, Alessio Gori
doaj   +1 more source

An Animal‐Free Patient‐Derived Tissue‐Mimetic Biochip Model of the Human Synovial Membrane for Human‐Relevant Osteoarthritis Research

open access: yesAdvanced Healthcare Materials, EarlyView.
Reihs et al. present the development of a humanized, animal‐free synovial membrane model for osteoarthritis. Methods include 3D biochip cultures of human‐primary OA synoviocytes with matrix and serum surrogates. Results show replication of synovial architecture and increased Yap1 expression.
Eva I. Reihs   +17 more
wiley   +1 more source

Colon‐Targeted Natural Polysaccharide‐Berberine Armored Hydrogel for the Treatment of Colitis

open access: yesAdvanced Healthcare Materials, EarlyView.
In this research, a novel hydrogel system targeting the colon is developed, incorporating Rhubarb polysaccharides and berberine‐loaded dendrimer. This hydrogel, forms through intermolecular hydrogen bonding and electrostatic interactions, accumulates in colonic tissues, effectively alleviating pathological immune hyperactivation while modulating gut ...
Miao Guo   +8 more
wiley   +1 more source

Opportunistic screening for alcohol use disorders in primary care: comparative study [PDF]

open access: bronze, 2006
Simon Coulton   +6 more
openalex   +1 more source

Rapid Deep Vat Printing Using Photoclickable Collagen‐Based Bioresins

open access: yesAdvanced Healthcare Materials, EarlyView.
Collagen‐based resin formulations based on thiol‐ene photoclick chemistry are demonstrated. These resins enable easy handleability under neutral conditions and further allow facile fabrication of multicellular tissue constructs via tomographic or FLight printing.
Michael Winkelbauer   +8 more
wiley   +1 more source

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