Results 241 to 250 of about 586,881 (303)

GLS1‐Mediated Redundancy in Glutamate Accelerates Arterial Calcification via Activating NMDAR/Ca2+/β‐Catenin Pathway

Advanced Science, EarlyView.
GLS1 is a novel contributor to arterial calcification. GLS1‐catalyzed glutamate exerts the promoting effects on osteogenic reprogramming in arteries. NMDAR, a glutamate receptor, is also activated and overexpressed during arterial calcification.
Ziting Zhou, Bing Dong, Dayu He, Jianshuai Ma, Yun Kong, Huijin Zhu, Chen Xie, Tiecheng Yang, Xin Zhen, Zhengzhipeng Zhang, Zhaohui He, Jinkun Cheng, Aoran Huang, Jie Chen, Ruo Wu, Huiyong Yin, Yanlian Chen, Jun Tao, Hui Huang   +18 more
wiley   +1 more source

Burden of alcohol use disorder, alcohol-related liver disease, and alcohol-related liver cancer: Editorial on "Global epidemiology of alcohol-related liver disease, liver cancer, and alcohol use disorder, 2000-2021. [PDF]

Clin Mol Hepatol
Wang Y, Oza N, Leo J, Choudhury A, Huang DQ.   +4 more
europepmc   +1 more source

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

Advanced Science, EarlyView.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu   +13 more
wiley   +1 more source

A preliminary randomized trial of the safety, tolerability, and clinical effects of hemp-derived cannabidiol in alcohol use disorder. [PDF]

Front Psychiatry
Mueller RL, Hooper JF, Ellingson JM, Olsavsky AK, Rzasa-Lynn R, Bryan AD, Bidwell LC, Hutchison KE.   +7 more
europepmc   +1 more source

Alcohol use disorder-personality disorder comorbidity: Reanalysis of NESARC data [PDF]

, 2009
Jahng, Seungmin, Sher, Ken, Steinley, Doug, Tomko, Rachel, Tragesser, Sarah, Trull, Tim, Wood, Phil   +6 more
core   +1 more source

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

Advanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao, Zhongkun Zhang, Minzi Ju, Liang Bian, Huijuan Wang, Sibo Zhao, Ningbo Cai, Yu Wang, Yanpeng Jia, Ling Shen, Yuan Zhang, Honghong Yao   +11 more
wiley   +1 more source

Alcohol Use Disorder Diagnoses Among Individuals Who Take HIV Preexposure Prophylaxis.

JAMA Netw Open
Avanceña ALV, Okoye G, Yokananth R, Norwood A, Schnarrs PW.   +4 more
europepmc   +1 more source

Species differences in comorbid alcohol use disorder and major depressive disorder: A narrative review. [PDF]

Alcohol Clin Exp Res (Hoboken)
Winkler GA, Grahame NJ.
europepmc   +1 more source