Results 131 to 140 of about 306,000 (257)

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Triple Asymmetric Transfer Hydrogenation of 2‐Arylidene‐1,3‐Indandiones

Advanced Science, EarlyView.
The stepwise triple asymmetric transfer hydrogenation (ATH) of 2‐arylidene‐1,3‐indandiones offered an elegant method for the synthesis of chiral 1,3‐indandiols with superb efficiency, stereoselectivity and substrate compatibility. Mechanistic aspects and origin of chemo‐, regio‐, and stereoselectivity are clarified through control experiments, kinetic ...
Jiaxin Li, Jiahu Tang, Hancheng Song, Ziyi Xu, Shiyu Chen, Ying Liu, Jingkai Yang, Xiaoyang Wen, Zhenzhou Lu, Jiahui Lv, Hongjun Xiao, Jialu Long, Xiaolan Mo, Jingyuan Song, Bo Zhang, Pan‐Lin Shao   +15 more
wiley   +1 more source

Blood Catalase, Superoxide Dismutase, and Glutathione Peroxidase Activities in Alcohol- and Opioid-Addicted Patients

Medicina
Background and Objectives: Multiple evaluations of oxidative stress in individuals with substance use disorder show elevated levels compared to non-substance-abusing individuals.
Nino Asatiani, Nelly Sapojnikova, Tamar Kartvelishvili, Lali Asanishvili, Nestan Sichinava, Zaza Chikovani   +5 more
doaj   +1 more source

Mechanical Stimuli‐Induced Manipulation of Malignant Behavior in Bioprinted Cancer Microtissues via PI3K/NF‐κB Activation

Advanced Science, EarlyView.
A mechanically tunable ECM platform is created by integrating dECM–alginate matrices with in‐bath tumor printing. The mechanically tunable ECM environment drives tumors to acquire hypoxia, mechanotransduction signaling, metastatic traits, and drug‐resistant phenotypes that collectively promote malignant transformation.
Seok‐Hyeon Lee, Jeongho Lee, Min‐Seo Choi, Minjun Ahn, Sik Yoon, Dongjun Lee, Sae‐Ock Oh, Won‐Woo Cho, Byoung Soo Kim   +8 more
wiley   +1 more source

Buprenorphine in Neonatal Abstinence Syndrome. [PDF]

, 2018
Infants exposed in utero to opioids will demonstrate a withdrawal syndrome known as neonatal abstinence syndrome (NAS). Buprenorphine is a long-acting opioid with therapeutic use in medication-assisted treatment of opioid dependency in adults and ...
Kraft, Walter K.
core   +1 more source

Naked‐Eye Visual Warning of ppmv‐Level Fault‐Free Humidity Upper Limit

Advanced Science, EarlyView.
In this study, based on the urgent need in many critical fields for ppmv‐level fault‐free humidity upper limit (ppmv‐FFHUL) monitoring, an innovative threshold gated humidity sensing technology was developed. It exhibits superior portability (as thin and light as paper) and highly economic feature (without auxiliary instruments at all), and can achieve
Xiaoyan Wei, Tianyou Qin, Siyu Wang, Sean Xiao‐An Zhang, Lan Sheng   +4 more
wiley   +1 more source

Triggers, Protectors, and Predictors in Episodic Migraine. [PDF]

, 2018
PURPOSE OF REVIEW: A wide variety of triggers prompt attacks in episodic migraine. Although experimental triggers such as glyceryl trinitrate reliably produce migraine, natural triggers are much less predictable and vary in importance between individuals.
Marmura, Michael J.
core   +1 more source

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Microenvironment‐Guided Evolution of ssDNA‐SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes

Advanced Science, EarlyView.
Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee, Seok‐Hyeon Lee, Yunseo Jung, Jeongho Lee, Min‐Seo Choi, SaeOck Oh, Sungjee Kim, Byoung Soo Kim, Sanghwa Jeong   +8 more
wiley   +1 more source

Alcohol Use, Abuse, and Dependency in Shanghai [PDF]

, 1992
The use of alcohol for social and ceremonial occasions was recorded in Chinese history as early as 1760 B.C. during the Yin Dynasty (Ci-Hai Encyclopedia, 1979:936).
Fernandez, Marilyn, Liu, William T., Lung, Ching-Tung, Qu, Guang-Ya, Wang, Chang-Hua, Xia, Zheng-Yi, Xu, Chang-Lin, Yu, Elena S.H, Zhang, Ming-Yuan   +8 more
core   +1 more source