Results 111 to 120 of about 872,006 (287)
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
Cover of Alcohol Education Materials
, 1975 Cover of the publication Alcohol education materials: an annotated bibliography by Gail G. Milgram published by the Publications Division, Rutgers Center of Alcohol Studies in 1975.Source: Alcohol education materials: an annotated bibliography by Gail G.
core +1 more source
Advanced Science, EarlyView.A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu +7 more
wiley +1 more source
, 2017 This chapter, “Alcohol Withdrawal,” reviews the prevalence, presentation, pathophysiology, and anesthetic considerations for patients encountered at risk of alcohol withdrawal, as well as current intensive care unit practices caring for patients at risk ...
Tracy McGrane
core +1 more source
Dual Nickel/Photoredox‐Catalyzed Regio‐ and Enantioselective Alkenylation of Epoxides
Advanced Science, EarlyView.Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Hongyan Lan +4 more
wiley +1 more source
Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer
Advanced Science, EarlyView.In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang +14 more
wiley +1 more source
Alterations of serum brain-derived neurotrophic factor levels in early alcohol withdrawal
, 2008 [[abstract]]Aims: Alcohol withdrawal-enhanced neurotoxicity contributes to the addictive process. Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal plasticity and learning.
Huang, MC; Chen, CH; Chen, CH; Liu, SC; Ho, CJ; Shen, WW; Leu, SJ
core +1 more source
Advanced Science, EarlyView.An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan +11 more
wiley +1 more source
, 1948 Originally published as Dr. Masserman's cats in the journal called Allied Youth in 1948, this copy of Alcohol, cats, and people written by E. M.
Jellinek, E. M. (Elvin Morton)
core +1 more source
Anxiolytic and Antianhedonic-like Effects of Psidium guajava Leaf in Alcohol-Withdrawn Mice
Journal of PharmacopunctureObjectives: Alcohol withdrawal syndrome manifests through a range of symptoms, including anxiety and anhedonia, significantly affecting the quality of life of those affected.
Vanjarapu Harithadevi, Vijayapandi Pandy
doaj +1 more source