Results 91 to 100 of about 48,367 (253)

The ‘Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease’ (PATROL) study

BJU International, EarlyView.
Background Inherited (germline) pathogenic and likely pathogenic variants (gPVs) in key genes associated with increased risk of prostate cancer (PCa) now warrant more attentive PCa screening per National Comprehensive Cancer Network (NCCN) guidelines—e.g., BRCA2, HOXB13, ATM, BRCA1, MSH2, MSH6, CHEK2 and TP53.
Heather H. Cheng, Kara N. Maxwell, Keyan Salari, Matthew R. Cooperberg, Kristin Follmer, Joanne M. Jeter, Grace Jun, Daniel J. Lee, Hiten D. Patel, Edward M. Schaeffer, Alexandra O. Sokolova, Erika M. Wolff, Daniel W. Lin   +12 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Positive and Negative Experiences of Caring Among Adolescent Young Carers

Children &Society, EarlyView.
ABSTRACT Research has highlighted that adolescent young carers (AYCs) are in a vulnerable position due to their caring responsibilities being combined with the challenges of adolescence. However, caring among adolescents does not have to be a solely negative experience and positive experiences of caring can co‐exist.
Miriam Svensson, Kevin J. McKee, Francesco Barbabella, Lennart Magnusson, Rosita Brolin, Elizabeth Hanson   +5 more
wiley   +1 more source

Continuous alcohol withdrawal delirium and physical illness‐associated delirium in a man brought to the emergency department after a disaster: A case report

Neuropsychopharmacology Reports
Background Risk factors for alcohol withdrawal delirium include heavy drinking, prior alcohol withdrawal delirium or convulsions, nondrug sedative use, and a history of tachycardia, withdrawal, and infections.
Kota Kikuchi, Chie Hasegawa, Taro Sasaki, Yoshiteru Sato, Tamaki Owada, Yunosuke Shindo, Yasushi Kawamata, Norio Sugawara, Norio Yasui‐Furukori   +8 more
doaj   +1 more source

Frontline Healthcare Professionals' Perceptions of the Duty to Care During the COVID‐19 Pandemic: A Multi‐Method Study in Mozambique

Developing World Bioethics, EarlyView.
ABSTRACT COVID‐19 intensified ethical tensions between clinicians' duty to care and self‐protection amid PPE shortages. We explored frontline healthcare professionals' perspectives in Maputo, Mozambique. Semi‐structured interviews with healthcare professionals at four hospitals (April–June 2022) were recorded in Portuguese, transcribed, and ...
Ângela Alface, Graça Salomé, Khátia Munguambe, Troy D. Moon, Esperança Sevene, Elizabeth Heitman   +5 more
wiley   +1 more source

Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib, Francisco Emilio Fierro, Maria Ortega Abad, Ricardo Correa   +3 more
wiley   +1 more source

Evaluation of phenobarbital dosing strategies for hospitalized patients with alcohol withdrawal syndrome. [PDF]

Gen Hosp Psychiatry, 2023
Stallworth S, Stilley K, Viriyakitja W, Powers S, Parish A, Erkanli A, Komisar J.   +6 more
europepmc   +1 more source

Insulin, Semaglutide and Dapagliflozin in Adults With Type 1 Diabetes: Design and Methods of Triple Therapy for Type 1 Diabetes (TTT1)—An International Phase 3 Clinical Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Attaining target glycaemia can be a challenge in Type 1 Diabetes (T1D) due to insulin‐induced weight gain. Adjunct therapy with modern glucose‐lowering agents developed for type 2 diabetes (T2D) has great potential but may be insufficiently efficacious and carries risks of hypoglycaemia and ketosis.
Joseph G. Timmons, Husam Ghanim, James G. Boyle, Nicola Greenlaw, Ajay Chaudhuri, Manav A. Batra, Robert S. Lindsay, Lisa Jolly, Caroline Bonner, Alex McConnachie, John R. Petrie, Paresh Dandona   +11 more
wiley   +1 more source

Alcohol-withdrawal Syndrome [PDF]

BMJ, 1965
openaire   +2 more sources