Results 191 to 200 of about 122,587 (295)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

ZSCAN25 methylation predicts seizures and severe alcohol withdrawal syndrome. [PDF]

Epigenetics
Andersen A, Milefchik E, Papworth E, Penaluna B, Dawes K, Moody J, Weeks G, Froehlich E, deBlois K, Long JD, Philibert R.   +10 more
europepmc   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, Volume 13, Issue 8, 9 February 2026.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Exploring core symptoms of alcohol withdrawal syndrome in alcohol use disorder patients: a network analysis approach. [PDF]

Front Psychiatry
Shen G, Chen YH, Wu Y, Jiahui H, Fang J, Jiayi T, Yimin K, Wang W, Liu Y, Wang F, Chen L.   +10 more
europepmc   +1 more source

Memantine treatment in alcohol dementia: Rapid PET changes and clinical course [PDF]

, 2001
Bahlmann, Miriam, Bartenstein, P., Preuss, Ulrich W., Schütz, Christian G., Soyka, Michael   +4 more
core   +1 more source

Urinary tract infection‐related delirium in Alzheimer's disease and related dementias: Clinical challenges and translational opportunities

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease and related dementias (ADRD) affects millions of patients worldwide and is a leading cause of morbidity in older adults. Patients with ADRD are particularly susceptible to developing urinary tract infection (UTI) and UTI‐related delirium, creating a self‐perpetuating cycle in which ADRD increases vulnerability to infection ...
Sarah Kim, Sarah Kremen, Itai Danovitch, Shouri Lahiri   +3 more
wiley   +1 more source

Real-world analysis on the use of gamma-hydroxybutyric acid for alcohol withdrawal syndrome in hospitalized patients with diagnosis of cirrhosis. [PDF]

Intern Emerg Med
Salomoni M, Missanelli A, Crescioli G, Lanzi C, Totti A, Losso L, Gitto S, Bonaiuti R, Vannacci A, Lombardi N, Mannaioni G.   +10 more
europepmc   +1 more source

CYP2C19 genotype testing for clopidogrel: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 329-347, February 2026.
Clopidogrel, an antiplatelet agent, is currently licensed in the United Kingdom for the prevention and treatment of atherothrombotic events in cerebrovascular disease, coronary artery disease and peripheral arterial disease. Clopidogrel requires metabolic activation by the cytochrome P450 enzyme CYP2C19 to be effective.
Cinzia Dello Russo, Iain Frater, Rebecca Kuruvilla, Stefanie Lip, Hannah O'Neill, Kerry Burke, Vicky Chaplin, Alexander S. F. Doney, Salim Elyas, Nicholas Greaves, Sophie Harding, David Hargroves, Judith Hayward, Dyfrig A. Hughes, Tom A. T. Hughes, Sree Kondapally, Patrick Mok, Aaron Peace, Imran Rafi, Simon Ray, Vicky Stinton, Luigi Venetucci, Munir Pirmohamed   +22 more
wiley   +1 more source

Clinical Characteristics and Treatment Outcomes of Alcohol Withdrawal Syndrome in Adolescents and Young Adults. [PDF]

JAACAP Open
Unlu H, Yehia A, El-Gayar S, Havanur A, Deceus F, Brown SJ, Umar SB, Croarkin PE, Schneekloth TD, Abulseoud OA.   +9 more
europepmc   +1 more source