Results 191 to 200 of about 48,367 (253)

Short‐Term Risk Stratification in Alcohol‐Associated Hepatitis: Small HDL Particles and Inflammation Vulnerability Index Values Improve Model for End‐Stage Liver Disease

Alcohol, Clinical and Experimental Research, Volume 50, Issue 8, August 2026.
Lower small HDL particles (S‐HDL‐P), the key component of the Inflammation Vulnerability Index, were associated with greater alcohol‐associated hepatitis (AH) severity and higher 90‐day AH‐related mortality. S‐HDL‐P improved Model for End‐Stage Liver Disease (MELD)‐based prognostic model fit, while IVX (inflammation vulnerability index) provided ...
Eduardo Vilar‐Gomez, Margery A. Connelly, Vijay H. Shah, Irina Shalaurova, Jill M. Rafalko, Arun J. Sanyal, Naga P. Chalasani, Samer Gawrieh, for the TREAT Consortium   +8 more
wiley   +1 more source

Brexanolone, a First‐In‐Class Neurosteroid Medication: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Given the increasing prevalence of postpartum depression (PPD) and the stigma associated with this condition, it is essential to address this significant health concern. Brexanolone is an FDA‐approved treatment for PPD that works by positive‐allosteric modulation of type A γ‐aminobutyric acid (GABAA) receptors.
Laura Gayanova, Katrina Sian, Jason Wells, Amber Fedin, YanFei Qi   +4 more
wiley   +1 more source

Evaluation of the Use of Phenobarbital and Benzodiazepines in the Management of Alcohol Withdrawal Syndrome in Patients Requiring Neurological/Neurosurgical Critical Care: A Propensity-Matched Analysis. [PDF]

Cureus
Norris M, Mak H, Fong CT, Walters AM, Hoang CV, Lele AV.   +5 more
europepmc   +1 more source

Association of the NOS1AP rs10494366 Genetic Variant With Drug‐Induced QT Prolongation

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Drug‐induced QTc prolongation (diQTP) is a major risk factor for torsades de pointes and sudden cardiac death. This study evaluated whether carriers of the G allele of the NOS1AP rs10494366 T > G variant have greater risk for diQTP when prescribed high‐risk QT‐prolonging medications.
Christina A. Pippis, Ana I. Lopez‐Medina, Choudhary Anwar A. Chahal, Jasmine A. Luzum   +3 more
wiley   +1 more source

Erratum: Management of alcohol withdrawal syndrome in patients with alcohol-associated liver disease. [PDF]

Hepatol Commun
europepmc   +1 more source

Evaluation of the Safety, Efficacy and Pharmacokinetics of BGM0504 in Chinese Adults With Type 2 Diabetes: A Multicentre, Randomised, Controlled and Double‐Blind Phase II Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7073-7082, August 2026.
ABSTRACT Aim This study aimed to evaluate its safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy in Chinese adults with T2DM and to preliminarily compare its efficacy and safety with semaglutide through multiple subcutaneous injections. Materials and Methods In this multicentre, randomised, placebo‐controlled and semaglutide‐positive‐
Ping Jin, Linong Ji, Yangqing Huang, Haifeng Ding, Daosheng Xie, Xiaohui Jiang, Xuemei Yuan, Zhao Cao, Haibin Zhang, Jiandong Yuan   +9 more
wiley   +1 more source

Semaglutide Injection in Indian Patients With Type 2 Diabetes Mellitus: A Randomised, Phase III, Active‐Controlled Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7094-7103, August 2026.
ABSTRACT Aim To evaluate the efficacy, safety and immunogenicity of semaglutide injection (synthetic) (Test group) compared with the Reference semaglutide injection [Ozempic, (Reference group)] in Indian patients with Type 2 diabetes mellitus (T2DM).
Unnikrishnan Ambika Gopalakrishnan, Ameya Sudhakar Joshi, Richa Giri, Shalin Jagdeep Shah, Jitendra Shukla, Sanjiv Maheshwari, Rekha M. Chowdaiah, Manish Kumar Singh, Aditya Srirang Bari, Niranjan Pandurang Pathak, Akash Nitinbhai Shah, Shweta Bhandari, Ambanna Gowda, Ambrish Chandrappa, Pravin Dinkar Supe, Bharat Das, Prabhat Kumar Sharma, Mehul Kalubhai Virani, Prakash Harishchandra Kurmi, Gayatri Amit Ghanekar, Mani Deepathi Dasari, Banshidhar Sahoo, Sanjay Kumar Jangid, Prakash Sadashiv Shende, Sandesh Sahebarao Patil, Avinash Narayan Kumbhar, Shrikant Vishnu Deshpande, Madhusudhan Chennappa, Nitesh Chandubhai Patel, Dipesh Sonawane, Dipak Patil, Sucheta Pandit, Pravin Ghadge, Suyog Mehta   +33 more
wiley   +1 more source

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The alcohol withdrawal syndrome

Lancet, The, 1997
The alcohol withdrawal syndrome (AWS) is a set of signs and symptoms that typically develops in alcohol-dependent people within 6–24 h of their last drink. It may occur unintentionally if abstinence is enforced by illness or injury, or deliberately if the person voluntarily stops drinking because of an alcohol-related illness, or as a prelude to ...
Wayne Hall, D ZÁDOR
exaly   +6 more sources

Alcohol Withdrawal Syndrome

Critical Care Clinics, 2012
In susceptible patients, alcohol withdrawal syndrome (AWS) is often precipitated by other medical or surgical disorders, and AWS can adversely affect the course of these underlying conditions. Although the mortality rate of AWS has decreased over the past few decades, significant risk for morbidity and death remain if management is complicated by a ...
Richard W, Carlson, Nivedita N, Kumar, Edna, Wong-Mckinstry, Srikala, Ayyagari, Nitin, Puri, Frank K, Jackson, Shivaramaiah, Shashikumar   +6 more
exaly   +3 more sources