Results 221 to 230 of about 122,587 (295)

Emergency department presentations, hospitalisations and police seizure data related to gamma‐hydroxybutyrate (GHB) in New South Wales, Australia, from 2015 to 2024

open access: yesAddiction, Volume 121, Issue 2, Page 305-315, February 2026.
Abstract Background and aims Gamma‐hydroxybutyrate (GHB) is an endogenous neurochemical and illicit synthetic drug. Its precursors, gamma‐butyrolactone (GBL) and 1,4‐butanediol (1,4‐BD), are often used as substitutes. We aimed to describe GHB‐related harms in New South Wales (NSW), Australia.
Krista J. Siefried   +9 more
wiley   +1 more source

The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications

open access: yesClinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Ecopipam is a first‐in‐class dopamine D1 receptor antagonist under investigation for the treatment of Tourette syndrome. This open‐label, fixed‐sequence, three‐cohort study evaluated whether ecopipam induces or inhibits cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, organic anion‐transporting polypeptide (OATP) 1B1, and p ...
Virginia D. Schmith   +4 more
wiley   +1 more source

Can ammonia scavenging treat MASLD? Evaluating the evidence for L‐ornithine L‐aspartate—A systematic review

open access: yesEuropean Journal of Clinical Investigation, Volume 56, Issue 2, February 2026.
Abstract Introduction While hyperammonemia is traditionally associated with decompensated cirrhosis, emerging evidence suggests that disturbances in nitrogen homeostasis contribute to disease progression in earlier stages of steatohepatitis and fibrosis.
Abdulrahman Ismaiel   +3 more
wiley   +1 more source

1‐Year Clinical Outcome Post‐Myasthenic Crisis: A Multicenter Prospective Study in China

open access: yesEuropean Journal of Neurology, Volume 33, Issue 2, February 2026.
In this prospective cohort of 282 patients with myasthenic crisis (MC) episodes, all‐cause mortality was 15.16%. Among 247 patients who have completed 1‐year follow‐up, 79.76% achieved favorable outcomes with significant improvement in the MG‐activities of daily living (MG‐ADL) score.
Xiao Huan   +38 more
wiley   +1 more source

Emergency Department Presentations for Mental Health Crisis: Comparing ED‐Only Care With Transfer to a Crisis Stabilisation Unit

open access: yesInternational Journal of Mental Health Nursing, Volume 35, Issue 1, February 2026.
Emergency Department presentations for mental health crisis: Comparing ED‐only care with transfer to a Crisis Stabilisation Unit. ABSTRACT Emergency departments (EDs) are often the first point of contact for individuals experiencing mental health crises; however, they remain unsuitable to cater to the complex needs of mental health patients.
Carly Hudson, Marcus Randall
wiley   +1 more source

Patient Agitation in the Intensive Care Unit: A Concept Analysis

open access: yesJournal of Advanced Nursing, Volume 82, Issue 2, Page 1737-1749, February 2026.
ABSTRACT Aim Exploring the concept of patient agitation in the intensive care unit. Background Patient agitation in the intensive care unit is of widespread concern and linked to negative outcomes for patients, staff, and family members. There is currently no consensus on what constitutes agitation in the intensive care context, hindering effective and
Anne Mette N. Adams   +7 more
wiley   +1 more source

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