Results 221 to 230 of about 122,587 (295)
Abstract Background and aims Gamma‐hydroxybutyrate (GHB) is an endogenous neurochemical and illicit synthetic drug. Its precursors, gamma‐butyrolactone (GBL) and 1,4‐butanediol (1,4‐BD), are often used as substitutes. We aimed to describe GHB‐related harms in New South Wales (NSW), Australia.
Krista J. Siefried +9 more
wiley +1 more source
The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications
ABSTRACT Ecopipam is a first‐in‐class dopamine D1 receptor antagonist under investigation for the treatment of Tourette syndrome. This open‐label, fixed‐sequence, three‐cohort study evaluated whether ecopipam induces or inhibits cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, organic anion‐transporting polypeptide (OATP) 1B1, and p ...
Virginia D. Schmith +4 more
wiley +1 more source
Abstract Introduction While hyperammonemia is traditionally associated with decompensated cirrhosis, emerging evidence suggests that disturbances in nitrogen homeostasis contribute to disease progression in earlier stages of steatohepatitis and fibrosis.
Abdulrahman Ismaiel +3 more
wiley +1 more source
1‐Year Clinical Outcome Post‐Myasthenic Crisis: A Multicenter Prospective Study in China
In this prospective cohort of 282 patients with myasthenic crisis (MC) episodes, all‐cause mortality was 15.16%. Among 247 patients who have completed 1‐year follow‐up, 79.76% achieved favorable outcomes with significant improvement in the MG‐activities of daily living (MG‐ADL) score.
Xiao Huan +38 more
wiley +1 more source
Emergency Department presentations for mental health crisis: Comparing ED‐only care with transfer to a Crisis Stabilisation Unit. ABSTRACT Emergency departments (EDs) are often the first point of contact for individuals experiencing mental health crises; however, they remain unsuitable to cater to the complex needs of mental health patients.
Carly Hudson, Marcus Randall
wiley +1 more source
Evaluation of the Use of Phenobarbital and Benzodiazepines in the Management of Alcohol Withdrawal Syndrome in Patients Requiring Neurological/Neurosurgical Critical Care: A Propensity-Matched Analysis. [PDF]
Norris M +5 more
europepmc +1 more source
Patient Agitation in the Intensive Care Unit: A Concept Analysis
ABSTRACT Aim Exploring the concept of patient agitation in the intensive care unit. Background Patient agitation in the intensive care unit is of widespread concern and linked to negative outcomes for patients, staff, and family members. There is currently no consensus on what constitutes agitation in the intensive care context, hindering effective and
Anne Mette N. Adams +7 more
wiley +1 more source

