Results 121 to 130 of about 658,178 (349)
Chemistry &Biodiversity, EarlyView.ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves +3 more
wiley +1 more source
THE TREATMENT OF ALCOHOLIC HEPATITIS [PDF]
Alcohol and Alcoholism, 1996 Alcoholic hepatitis is a precirrhotic lesion; it develops in only a minority of chronic alcohol abusers even after decades of abuse. The clinical spectrum of disease varies from asymptomatic hepatomegaly to florid hepatocellular failure with gastrointestinal bleeding and hepatic encephalopathy.
openaire +3 more sources
Clinical Pharmacology in Drug Development, EarlyView.Abstract Cytochrome P450 (CYP) 3A plays a significant role in fruquintinib metabolism in vitro. This 2‐part, 2‐period fixed‐sequence study investigated the impact of CYP3A inhibition (itraconazole) and CYP3A induction (rifampin) on the pharmacokinetics (PK) of fruquintinib and M11, its main metabolite.
Martha Gonzalez +5 more
wiley +1 more source
Populations Addressed in Vaccines Approved via the European Medicines Agency
Clinical Pharmacology &Therapeutics, EarlyView.Therapeutic and prophylactic agents require robust evidence before patient use. Randomized controlled trials are essential for evaluating safety and efficacy but often exclude specific populations that are also targets for the intervention. This study assessed which populations are included in vaccine registration studies and/or addressed in label ...
Débora D. Gräf +3 more
wiley +1 more source
Current management of alcoholic liver disease
Фундаментальная и клиническая медицина, 2019 In Russia, liver diseases largely contribute to the mortality. Here we review the literature on current management of alcoholic liver disease, which remains the leading cause of cirrhosis worldwide.
V. V. Tsukanov +2 more
doaj +1 more source
Rethinking Chlorine: Essential Chemical or Replaceable Risk?
ChemSusChem, EarlyView.Chlorine is essential for the production of plastics and pharmaceuticals but poses significant safety and environmental risks. Herein, processes are presented that substitute chlorine or reduce its demand. Where indispensable, trichloride‐ and bichloride‐based ionic liquids could enhance safety and streamline the integration of renewable energy ...
Johannes Schwan +6 more
wiley +1 more source
Discovering new hub genes of dilated cardiomyopathy
ESC Heart Failure, EarlyView.Abstract Aims Dilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of DCM by mining the human DCM databases and further by experimental validation.
Jun‐Yan Zhu +9 more
wiley +1 more source
Journal of Infection in Developing Countries, 2015 Introduction: The aims of this study were to detect the seroprevalence of hepatitis A, B, and C viruses in Turkish alcoholic cirrhotics, and to evaluate the impact of hepatitis B infection on clinical profile at first admittance.
Fatih Tekin +7 more
doaj +1 more source
Survival from alcoholic hepatitis has not improved over time
PLoS ONE, 2018 Purpose/Background We aimed to describe changes in survival in alcoholic hepatitis (AH) over time by examining published data. Methods A systematic literature search of Ovid Embase and PubMed was undertaken using the MESH terms ‘hepatitis, alcoholic’ to ...
E. Hughes, L. Hopkins, R. Parker
semanticscholar +1 more source
Contactless Conductivity Detection for Capillary Electrophoresis—Developments From 2020 to 2024
ELECTROPHORESIS, EarlyView.ABSTRACT The review covering the development of capillary electrophoresis with capacitively coupled contactless conductivity detection from 2020 to 2024 is the latest in a series going back to 2004. The article considers applications employing conventional capillaries and planar lab‐on‐chip devices as well as fundamental and technical developments of ...
Peter C. Hauser, Pavel Kubáň
wiley +1 more source