Results 191 to 200 of about 70,315 (252)

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

ADRB2 serves as a novel biomarker and attenuates alcoholic hepatitis via the SIRT1/PGC-1α/PPARα pathway: integration of WGCNA, machine learning and experimental validation. [PDF]

Front Pharmacol
Song L, Huang S, Yan H, Ma Q, Luo Q, Qiu J, Chen M, Li Z, Jiang H, Chen Y, Chen F, Du Y, Fu H, Zhao L, Zhao K, Qiu P.   +15 more
europepmc   +1 more source

Hand Hygiene Accuracy of Students and Staff at a Dutch Dental School

European Journal of Dental Education, EarlyView.
ABSTRACT Introduction Oral health care professionals continuously come into contact with bodily fluids containing many pathogens. Hand hygiene should be used to prevent cross transmission. We aimed to examine the accuracy of application of alcohol‐based hand rub (ABHR) according to the WHO hand hygiene steps at a dental school.
Ilona Francisca Persoon, Catherine Minke Charlotte Volgenant   +1 more
wiley   +1 more source

Italian Patients Journey for Gene Therapy in Haemophilia A

Haemophilia, EarlyView.
ABSTRACT Introduction Gene therapy (GT) provides sustained FVIII levels without repeated infusions in Hemophilia A (HA) patients thus overcoming a major limitation of replacement therapy. However, issues remain e.g., patient selection criteria, duration and variability of transgene expression, quality of life and long‐term safety.
Giovanni Di Minno, Gaia Spadarella, Alessandra Borchiellini, Anna Borrelli, Andrea Buzzi, Giancarlo Castaman, Michele Cecchi, Raimondo De Cristofaro, Vincenzo La Mura, Angelo Lupi, Giuseppe Malcangi, Maria Elisa Mancuso, Maria Francesca Mansueto, Cristina Santoro, Rita Carlotta Santoro, Luigi Piero Solimeno, Annarita Tagliaferri, Ezio Zanon, Isabella Garagiola, Flora Peyvandi   +19 more
wiley   +1 more source

Prognostic Value of PALBI in Patients With Hepatocellular Carcinoma and Concurrent Chronic Kidney Disease: A Nomogram Development

Hepatology Research, EarlyView.
Patients with hepatocellular carcinoma (HCC) as well as chronic kidney disease (CKD) are high‐risk individuals, making it challenging to accurately predict their survival. We found that the PALBI grade model when combined with other patient's clinical and tumor‐related factors, forms a new and highly accurate prediction tool to estimate their ...
Jihye Lim, Seok–Hwan Kim, Myeong Jun Song   +2 more
wiley   +1 more source

Correction to “The Dynamic Evolution of Lipid Profiles Following Transjugular Intrahepatic Portosystemic Shunt in Patients With Liver Cirrhosis”

Portal Hypertension &Cirrhosis, EarlyView.
wiley   +1 more source

Diagnostic Impact of Two‐Dimensional Shear Wave Elastography for Liver Fibrosis: A Multicenter Retrospective Study

Hepatology Research, EarlyView.
Two‐dimensional shear wave elastography demonstrated strong correlation with magnetic resonance elastography and high diagnostic accuracy for liver fibrosis across stages in 744 patients with chronic liver disease, supporting its role as a reliable non‐invasive tool for fibrosis assessment.
Takashi Nishimura, Toshifumi Tada, Yasuaki Suzuki, Kento Imajo, Katsutoshi Sugimoto, Sadanobu Ogawa, Hidenori Toyoda, Tamami Abe, Hidekatsu Kuroda, Masashi Hirooka, Asako Nogami, Satoshi Oeda, Hirokazu Takahashi, Tomoyuki Akita, Reiichiro Kondo, Takuma Nakatsuka, Ryosuke Tateishi, Yoichi Hiasa, Yuichiro Eguchi, Atsushi Nakajima, Hirohisa Yano, Shigehiro Kokubu, Junko Tanaka, Fuminori Moriyasu, Masayoshi Kage, Takashi Kumada, Hiroko Iijima   +26 more
wiley   +1 more source

A Novel Diagnostic Approach for Hepatocellular Carcinoma Using Glycosylated Ferritin

Hepatology Research, EarlyView.
The percentage of glycosylated ferritin relative to total ferritin (%GF) is a novel biomarker for hepatocellular carcinoma (HCC), showing diagnostic performance comparable to that of AFP and DCP. We developed the GFAD index by integrating age, sex, %GF, AFP, and DCP, achieving improved diagnostic accuracy with high sensitivity and specificity. ABSTRACT
Akiyo Ishiguro, Yutaka Suehiro, Issei Saeki, Maho Egusa, Norikazu Tanabe, Toshihiko Matsumoto, Tsuyoshi Ishikawa, Yuki Kunimune, Toshihiko Kobayashi, Mitsuaki Nishioka, Taro Takami, Takahiro Yamasaki   +11 more
wiley   +1 more source

Depletion of Activated Hepatic Stellate Cells and Capillarized Liver Sinusoidal Endothelial Cells Using a Rationally Designed Protein for Nonalcoholic Steatohepatitis and Alcoholic Hepatitis Treatment. [PDF]

Int J Mol Sci
Mishra F, Yuan Y, Yang JJ, Yang JJ, Li B, Chan P, Liu Z.   +6 more
europepmc   +1 more source