Results 141 to 150 of about 157,814 (202)

Controlled Trial of Cervical Cancer Screening Frequency Among Human Papillomavirus Vaccinated Women II: Cervical Pre‐Cancer End‐Points by Specific Non‐Vaccine HPV Types

International Journal of Cancer, EarlyView.
ABSTRACT We conducted a controlled trial among 5626 early adolescent women vaccinated in 2007–2009 against human papillomavirus (HPV) types 16/18 to evaluate the impact of high‐intensity versus low‐intensity cervical screening, respectively at ages 22/25/28 and 28 years with squamous‐cell intraepithelial lesions (SILs) as the end‐point.
Matti Lehtinen, Mònica Ortega Llobet, Tiina Eriksson, Iacopo Baussano, Miriam Elfström, Mehran Ghaderi, Penelope Gray, Katja Harjula, Kaisa Heikkilä, Mari Hokkanen, Saara Kares, Camilla Lagheden, Pekka Nieminen, Anna Söderlund‐Strand, Joakim Dillner, Ville N. Pimenoff   +15 more
wiley   +1 more source

The female journey following sexual assault: Medical care, law enforcement and judicial outcomes

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Sexual violence affects 22% of Australian women, posing health and justice challenges. Systemic failures, fragmented data, and low conviction rates hinder effective responses. This study integrates Australian Capital Territory (ACT) medical and policing datasets to examine victim characteristics and case progression from clinical ...
Vanita Parekh, Michael Woodburn, Stephanie Leonard, Bridget Bourke, Janine McMinn, Anna Brkic, Ash Byron, Katelyn Pomroy   +7 more
wiley   +1 more source

Biochemical and Molecular Insights Into Monocrotaline‐Induced Hepatotoxicity: An Experimental Mouse Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol, Alparslan Kadir Devrim, Miyase Çinar, Mahmut Sözmen, Fatma Betül Akça   +4 more
wiley   +1 more source

Chlorfenapyr Induces Hepatotoxicity Associated With Oxidative Stress and Mitochondrial Dysfunction Involving Keap1/Nrf2 Signaling

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorfenapyr (CHL) is a widely used pyrrole insecticide, but its hepatotoxic effects and underlying mechanisms remain incompletely understood. This study investigated the toxic effects of CHL on rat liver and BRL‐3A hepatocytes and explored the involvement of the Keap1/Nrf2 signaling pathway. Rats were administered CHL (10, 20, or 30 mg/kg) by
Dongquan Zhao, Jia Li, Cheng Li, Hua He, Lipu Deng   +4 more
wiley   +1 more source

Causes of death among veterans with alcohol use disorder‐related conditions: A 5‐year follow‐up study of Veterans Health Administration hospitalizations

Journal of Hospital Medicine, EarlyView.
Abstract Background Alcohol use disorder‐related (AUD) diagnoses are common among hospitalized Veterans. Our prior research found that the presence of any AUD‐related diagnosis during hospital admission is associated with a 30% 5‐year mortality rate. Objective To compare demographics and causes of death between hospitalized patients within the Veterans
James C. Willey, Shivali Patel, Bjarni Haraldsson, George Bailey, Andrea Holcombe, Amy M. J. O'Shea, Thad Abrams, Jeydith Gutierrez   +7 more
wiley   +1 more source

Hospitalist perspectives and practices in treating hospitalized patients with alcohol withdrawal syndrome in the era of phenobarbital re‐emergence

Journal of Hospital Medicine, EarlyView.
Abstract Medication treatment for moderate to severe alcohol withdrawal syndrome (AWS) is evolving, particularly with renewed phenobarbital use. However, little research has examined how hospitalists manage AWS. We conducted a multiple‐methods study involving hospitalists from a national US Hospital Medicine research network.
James C. Willey, Julia E. Szymczak, Andrew D. Auerbach, Jeffrey L. Schnipper, Sunil Kripalani, Troy E. Madsen, Evan Done, Michael A. Incze, Valerie M. Vaughn, James D. Harrison   +9 more
wiley   +1 more source

Effects of oat protein on hematological parameters and metabolism in Wistar rats

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Diets rich in plant‐based proteins are becoming increasingly popular, but the safety of extracted oat (Avena sativa L.) protein in relation to cardiometabolic and endocrine risks remains unexplored. This study evaluated the safety of oat protein by analyzing anthropometric, hematological, biochemical, and histopathological ...
Gabriela Matte Bertoldi, Karine Raquel Uhdich Kleibert, Flávia Alessandra da Silva Räder, Alana Thais Gisch Andres, Luciana Mori Viero, Maria Andréia Inkelmann, José Antonio Gonzalez da Silva, Ivan Ricardo Carvalho, Christiane de Fátima Colet   +8 more
wiley   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Precisely Engineered Ultrathin Nanosheets With Amorphous Ni(OH)x‐Encapsulated Ru Nanoclusters for Enhanced Water Splitting in Neutral Media

National Materials, EarlyView.
An ultrathin 2D nanosheet composite of ultrafine Ru nanoclusters embedded in amorphous Ni(OH)x was synthesized in one step. Synergistic Ru‐Ni(OH)x interactions and abundant Ni–O–Ru interfacial sites provide excellent catalytic activity, robust stability, and highly efficient hydrogen evolution in both neutral and alkaline electrolytes under practical ...
Jifang Zhang, Zenglong Wu, Pengqi Yang, Xinyuan Zhang, Zhixian Mao, Tengxiu Tu, Mengfan Bi, Jian Kang, Yijin Wu, Shan Chen, Porun Liu, Xiangyang Li, Huajie Yin, Huijun Zhao   +13 more
wiley   +1 more source