Results 141 to 150 of about 387,405 (380)
Alcohol, Clinical and Experimental Research, EarlyView.This RCT evaluated whether the glycine receptor (GlyR) agonist glycine reduces craving and alcohol intake in individuals with AUD. Despite a preclinical rationale for targeting the GlyR, these parameters were not reduced. Interestingly, glycine weakened the link between alcohol‐induced craving and self‐administration, and baseline glycine levels were ...
Yasmin Olsson +3 more
wiley +1 more source
Nature CommunicationsOnly ~20% of heavy drinkers develop alcohol cirrhosis (AC). While differences in metabolism, inflammation, signaling, microbiome signatures and genetic variations have been tied to the pathogenesis of AC, the key underlying mechanisms for this ...
Bani Mukhopadhyay +12 more
doaj +1 more source
Alcohol, Clinical and Experimental Research, EarlyView.This study investigates the impact of global Cyp2e1 knockout and wild‐type mice to explore the effect of altered ethanol metabolism on behavior and gene expression. Knockout mice demonstrated altered alcohol‐related pathways, increased ethanol sensitivity, and escalated drinking.
Hyland C. Gonzalez +7 more
wiley +1 more source
Alcohol, Clinical and Experimental Research, EarlyView.Participants (n = 236) from three sites were randomly assigned to either placebo, low‐dose topiramate (up to 125 mg/day), or high‐dose topiramate (up to 250 mg/day) for up to 18 weeks. Exploratory analyses indicated that participants treated with the high dose had lower mean percentage of heavy drinking days and drinks per day than those taking the low
Jason D. Robinson +6 more
wiley +1 more source
Alcohol, Clinical and Experimental Research, EarlyView.This study investigates the bidirectional and potentially causal association between alcohol use and suicidal thoughts and behaviors (STB). Analyses combined two complementary and well‐validated methods to assess causality: The cross‐lagged panel and the co‐relative designs.
Séverine Lannoy +4 more
wiley +1 more source
, 2017 The Japanese success rate for alcoholism treatment is approximately 30%, indicating high relapse rates. Although “difficulty in life” is thought to contribute to alcoholics’ relapse, the characteristics of the phenomenon are unknown.
Ito, Keiko
core +3 more sources
Alcohol, Clinical and Experimental Research, EarlyView.Prenatal alcohol exposure (PAE) significantly impacts cerebellum development, which may affect cognitive function in fetal alcohol spectrum disorders (FASD). Using an advanced MRI volumetric method that characterizes detailed cerebellum structure, this study identified regional cerebellum volume anomalies in children with FASD age 8–17 years ...
Blake A. Gimbel +9 more
wiley +1 more source
Psychopathology and Creativity Among Creative and Non-Creative Professions [PDF]
, 2016 The mad genius debate has been a topic that has been discussed in both popular culture and academic discourse. The current study sought to replicate previous findings that linked psychopathology to creativity.
Kwan, Victor
core +1 more source
Psychological Complexity of Self‐control Impairment in Alcoholism [PDF]
, 1987 Alfred B. Heilbrun, Julie R. Abraham
openalex +1 more source
Alcohol, Clinical and Experimental Research, EarlyView.Two small placebo‐controlled trials evaluated the effects of cannabidiol (CBD) in patients with alcohol use disorder (AUD), with and without co‐occurring post‐traumatic stress disorder (PTSD). CBD was rapidly absorbed and generally well tolerated in dosages of up to 1200 mg/day. Both treatment groups showed large reductions in drinking.
Michael P. Bogenschutz +6 more
wiley +1 more source