Results 81 to 90 of about 118,083 (262)

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Early life stress and body-mass-index modulate brain connectivity in alcohol use disorder

Translational Psychiatry
Early life stress (ELS) significantly increases susceptibility to alcohol use disorder (AUD) by affecting the interplay between the executive and the salience networks (SNs).
Khushbu Agarwal, Paule V. Joseph, Rui Zhang, Melanie L. Schwandt, Vijay A. Ramchandani, Nancy Diazgranados, David Goldman, Reza Momenan   +7 more
doaj   +1 more source

Longitudinal Associations between Depression, Daytime Sleepiness, and Caregiver Strain in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Objective Examine the longitudinal relationship between caregiver strain and Parkinson's patient depression, daytime sleepiness, and treatment with dopamine agonists and antidepressants. Background Parkinson's disease (PD) is a neurodegenerative disorder, in which family caregivers play an integral role in patient care.
Sarah Holden, Sean P. Lane, Madison Christopher, Lisa Mann, Julie H. Carter, Joseph Quinn, Jiayun Xu   +6 more
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Mobilizing Presence across Borders: Devotion to Papua New Guinea's Blessed Peter To Rot in Australia

Oceania, EarlyView.
ABSTRACT This article engages with the conjunctures between migration and religion by focusing on the celebration of Papua New Guinea's ‘National Patron Saint’, the Blessed Peter To Rot, in the Australian diaspora. Both in Sydney and Brisbane, Catholic Papua New Guinea (PNG) migrants have been ‘relocating’ PNG shrines, regalia, relics and ritual ...
Anna‐Karina Hermkens
wiley   +1 more source

Mechanistic Insights Into Hepatotoxicity‐Induced Liver Cirrhosis and Anemia: Iron Dysregulation, the Hepcidin–Ferroportin Axis, and Emerging Therapeutic Strategies

Organ Medicine, EarlyView.
Patients with alcohol‐associated liver cirrhosis or acetaminophen (APAP) toxicity frequently develop anemia with iron metabolism disturbances. Dysregulation of hepcidin–ferroportin signaling, along with inflammation, oxidative stress, hypoxia, impaired intestinal iron absorption, malnutrition, and gastrointestinal bleeding, contributes to anemia ...
Debabrata Dash, Raj Kumar Koiri
wiley   +1 more source

Rethinking Gender Representation in Policing: Experimental Insights on Citizen Trust and Cooperation in South Korea

Public Administration and Development, EarlyView.
ABSTRACT This study extends the literature on symbolic representation by examining how increased female representation affects citizens' attitudes in policy areas that are not typically salient to women. A survey experiment with South Korean citizens tested whether a greater presence of female police leaders overseeing patrol programs affects public ...
Sunyoung Pyo
wiley   +1 more source

A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis

Nature Communications
Only ~20% of heavy drinkers develop alcohol cirrhosis (AC). While differences in metabolism, inflammation, signaling, microbiome signatures and genetic variations have been tied to the pathogenesis of AC, the key underlying mechanisms for this ...
Bani Mukhopadhyay, Cheryl Marietta, Pei-Hong Shen, Abdul Oiseni, Faridoddin Mirshahi, Maria Mazzu, Colin Hodgkinson, Eli Winkler, Qiaoping Yuan, Daniel Miranda, George Kunos, Arun J. Sanyal, David Goldman   +12 more
doaj   +1 more source

Assessing Extracellular Vesicle Proteins as Predictive Biomarkers for Developing Type 1 Diabetes

PROTEOMICS, EarlyView.
ABSTRACT Plasma extracellular vesicles (EVs) are considered excellent sources for biomarker discovery since they carry signatures of their cellular origin and disease processes. In this paper, we evaluate the potential of plasma EV proteomics analysis for identifying predictive biomarkers of developing type 1 diabetes (T1D), which results from ...
Panshak P. Dakup, Lisa M. Bramer, Athena Schepmoes, Ivo Diaz Ludovico, Javier Flores, Raghavendra G. Mirmira, Bobbie‐Jo M. Webb‐Robertson, Thomas O. Metz, Emily K. Sims, Ernesto S. Nakayasu   +9 more
wiley   +1 more source