Results 81 to 90 of about 154,955 (297)

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Alcoholism recovery and treatment needs of women [PDF]

, 2003
Plan BAmong American women, alcohol is the single leading drug of abuse, yet research in addiction has concentrated on male subjects. Most models of treatment were developed to meet the needs of male patients.
Milton, Judith L.
core  

Suppression of PKM2 by Leonurine Attenuates Alcoholic Hepatitis Through Regulating Glycolytic Reprogramming

Phytotherapy Research, EarlyView.
Leonurine inhibits PKM2 to remodel hepatocyte glycolysis, thereby alleviating liver injury in alcoholic hepatitis. ABSTRACT Alcoholic hepatitis (AH) is a liver disease caused by long‐term heavy drinking. In the early stages, it usually manifests as fatty liver, which can then develop into liver fibrosis and cirrhosis.
Xuan‐Xuan Zhang, Gao‐Feng Pan, Hong Fang, Xiao‐Peng Liu, Jing Sun, Ji‐Xiang Chen, Xin Fan, Jia‐Hao Feng   +7 more
wiley   +1 more source

History of Suicidality and Pandemic Outcomes: Longitudinal Associations with Anxiety Symptoms, Depressive Symptoms, and Problematic Drinking

Psychiatric Research and Clinical Practice
Objective Individuals with a history of suicidality may be especially vulnerable to the adverse impact of COVID‐related stressors, but this vulnerability has not been demonstrated.
Jeremy W. Luk, Matthew F. Thompson, Laura A. Novak, Bethany L. Stangl, Melanie L. Schwandt, David Goldman, Vijay A. Ramchandani, Nancy Diazgranados   +7 more
doaj   +1 more source

Auto-FPFA: An Automated Microscope for Characterizing Genetically Encoded Biosensors

Scientific Reports, 2018
Genetically encoded biosensors function by linking structural change in a protein construct, typically tagged with one or more fluorescent proteins, to changes in a biological parameter of interest (such as calcium concentration, pH, phosphorylation ...
Tuan A. Nguyen, Henry L. Puhl, An K. Pham, Steven S. Vogel   +3 more
doaj   +1 more source

Alcoholism: a high priority health problem [PDF]

, 1977
This report summarizes the problem and the historical background of alcoholism, evaluates prevention programs, and offers a reference guide for tribes and communities wishing to undertake alcoholism ...
Indian Health Service Task Force on Alcoholism
core  

Toll‐Like Receptor 4 Signaling in Natural N‐Acylethanolamines and Derivative NAE‐Like Compounds: Mechanisms and Implications for Neuroimmune and Inflammatory Processes in a Systematic Search Approach

Phytotherapy Research, EarlyView.
ABSTRACT N‐acylethanolamines (NAEs) are endogenous fatty acid amides structurally related to the endocannabinoid anandamide and function as bioactive lipid mediators with broad regulatory roles in inflammation and neuroinflammation. Among pattern‐recognition receptors, Toll‐like receptor 4 (TLR4) occupies a central position in innate immune ...
Damiana Scuteri, Francesca Guida, Giacinto Bagetta, Sabatino Maione, Maria Tiziana Corasaniti, Morena Zusso   +5 more
wiley   +1 more source

Analysis of aminophospholipid molecular species by high performance liquid chromatography.

Journal of Lipid Research, 1989
A new method is described for the separation of individual molecular species of the aminophospholipids, phosphatidylethanolamine and phosphatidylserine. Trinitrobenzene-sulfonic acid was used to derivatize both aminophospholipids and the derivatives were
F Hullin, H Y Kim, N Salem, Jr
doaj   +1 more source

Accomplishing Ethics‐Work as a Generic Social Process

Symbolic Interaction, EarlyView.
Existing systems of university research ethics are often criticized by those in the qualitative research tradition. A common thread is that ethics cannot be fully anticipated before the research begins, as is expected by most institutional review boards.
Deana Simonetto, Antony Puddephatt
wiley   +1 more source

Associations of substance use and positive coping behaviors with sleep quality during the COVID-19 pandemic

Frontiers in Sleep
BackgroundThe COVID-19 pandemic may have negatively impacted individuals' sleep quality. In this study, we examined changes in sleep quality from before to during the COVID-19 pandemic by history of alcohol use disorder (AUD) and investigated the cross ...
Jessica Laudie, Bethany L. Stangl, Tommy Gunawan, Tommy Gunawan, Melanie L. Schwandt, Cecilia Cheng, Amanda K. Gilmore, Amanda K. Gilmore, David Goldman, David Goldman, Vijay A. Ramchandani, Nancy Diazgranados, Jeremy W. Luk   +12 more
doaj   +1 more source