From Dysbiosis to Disease: How Vaginal Microbiota Shape Group B Streptococcus Pathogenesis
ChemBioChem, Volume 27, Issue 20, 28 October 2026.Lactobacillus crispatus plays a critical role in the vaginal microbiome. Limiting glucose shifts metabolism toward HMO consumption and amino acid metabolism. These actions enable alkali production and competition. Homeostasis, characterized by dense Lactobacilli colonization and suppression of pathogens, provides resistance to dysbiosis.
Julie A. Talbert, Steven D. Townsend
wiley +1 more source
One Hundred Years of Sulfido Ligand in the Molybdenum Cofactor: New Perspectives
ChemBioChem, Volume 27, Issue 19, 14 October 2026.The terminal sulfido ligand in mononuclear molybdoenzymes has been appreciated for almost 125 years, with the characterization of Schardinger's enzyme in cow's milk, now known to be xanthine oxidase, that was isolated in 1902 in Vienna, Austria. The ligand is found in molybdoenzymes identified across all kingdoms of life.
Silke Leimkühler +2 more
wiley +1 more source
Aldehyde-Functional Diblock Copolymer Nano-objects via RAFT Aqueous Dispersion Polymerization
We report the rational design of aldehyde-functional sterically stabilized diblock copolymer nano-objects in aqueous solution via polymerization-induced self-assembly.
Mark J. Smallridge (1416730) +2 more
core +1 more source
TpPL7A and TpPL7B, members of CAZy family PL7, act as β-glucuronan lyases. TpPL7A diverges by lacking the catalytic histidine, identified as the Brønsted base in PL7 alginate lyases.
Vuillemin, Marlene +7 more
core +1 more source
ALDH2 mediates 5-nitrofuran activity in multiple species [PDF]
, 2012 Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of pro-drugs widely used to treat bacterial and trypanosome infections, but despite relative ...
Spitzer, Michaela +34 more
core +1 more source
Diversity of Three-Dimensional Structures and Catalytic Mechanisms of Alginate Lyases
, 2018 Alginate is a linear polysaccharide produced mainly by brown algae in marine environments. Alginate consists of a linear block copolymer made up of two monomeric units, β- d -mannuronate (M) and its C-5 epimer α- l
Peng Wang +3 more
core +1 more source
Comparative study on general properties of alginate lyases from some marine gastropod mollusks [PDF]
, 2009 Alginate lyase (EC 4.2.2.3) is an enzyme that splits glycosyl linkages of alginate chain via β-elimination producing unsaturated oligoalginates. This enzyme is widely distributed in herbivorous marine mollusks, brown algae, and marine and soil bacteria ...
Satoru Chiba +13 more
core +1 more source
PROPERTIES OF 2 PECTIN LYASES PRODUCED BY AUREOBASIDIUM-PULLULANS LV-10
, 1988 Two pectic lyases, L1 and L2, from culture liquids of Aureobasidium pullulans LV 10 were partially purified by ultrafiltration, CM-Sepharose 6B, DEAE-cellulose and/or Sephadex G 100 column chromatography, and characterized.
M. FORTINA, P. MANACHINI, C. PARINI
core +1 more source
Bacterial lyases as powerful tools to evaluate the structures of different glycosaminoglycans
, 1992 Bacterial lyases as powerful tools to evaluate the structures of different ...
VOLPI, Nicola, BOLOGNANI, Lorenzo
core
Effect of bacterial lyases on different molecular weight heparins and dermatan sulfate
, 1992 Effect of bacterial lyases on different molecular weight heparins and dermatan ...
VOLPI, Nicola +3 more
core