Results 241 to 250 of about 112,433 (285)

Uncovering newly identified aldehyde dehydrogenase 2 genetic variants that lead to acetaldehyde accumulation after an alcohol challenge. [PDF]

J Transl Med
Rwere F, White JR, Hell RCR, Yu X, Zeng X, McNeil L, Zhou KN, Angst MS, Chen CH, Mochly-Rosen D, Gross ER.   +10 more
europepmc   +1 more source

Integrated In Silico and In Vitro Study of Copper Nanocatalyzed Carbonyl‐Functionalized Triazoles—Inducing S Phase Cell Cycle Arrest and Apoptosis in MCF‐7

ChemistryOpen, Volume 15, Issue 1, January 2026.
A targeted drug discovery pipeline identified novel copper‐nanocatalyzed carbonyl‐functionalized triazoles as potent breast cancer therapeutics (selectivity index up to 4.44). Lead compounds (3i, 3j) induced apoptosis in breast cancer cells (MCF‐7) by modulating BAX/BCL2, causing reactive oxygen species (ROS)‐mediated glutathione (GSH) depletion ...
Joydip Mondal, Tiasha Dasgupta, Chitluri Kiran Kumar, Prasanth Babu Nandagopal, Sadananda Mal, Sourav Paul, Aishwarya S, Chayan Pandya, Isaac Arnold Emerson, Venkatraman Manickam, Akella Sivaramakrishna   +10 more
wiley   +1 more source

Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) Protects against Binge Alcohol-Mediated Gut and Brain Injury. [PDF]

Cells
Ray B, Rungratanawanich W, LeFort KR, Chidambaram SB, Song BJ.   +4 more
europepmc   +1 more source

Functionalizing Nucleic Acids: Synthesis and Purification Strategies for Bioconjugates as Biomaterials

Small, Volume 22, Issue 5, 22 January 2026.
Nucleic acid‐ligand conjugates combine the distinct properties of macromolecular ligands with the versatility of DNA/RNA nanotechnology. In biomaterial and nanomedicine applications, highly purified products are paramount, requiring reliable synthesis and purification methods.
Nico Alleva, Jian Zhang, David Y. W. Ng, Tanja Weil, Torsten John   +4 more
wiley   +1 more source

Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor. [PDF]

Molecules
Gowda K, Raza A, Vangala V, Lone NA, Lin JM, Singh JK, Srivastava SK, Schell TD, Robertson GP, Amin S, Sharma AK.   +10 more
europepmc   +1 more source

Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial Fibrillation Susceptibility: Unraveling the Connection. [PDF]

Int J Mol Sci
Hsu LA, Yeh YH, Chang CJ, Chen WJ, Tsai HY, Chang GJ.   +5 more
europepmc   +1 more source

Contribution of a C-Terminal Extension to the Substrate Affinity and Oligomeric Stability of Aldehyde Dehydrogenase from Thermus thermophilus HB27. [PDF]

Biochemistry
Brytan W, Shortall K, Duarte F, Soulimane T, Padrela L.   +4 more
europepmc   +1 more source

Comparison of the correlation between serum autoantibodies against aldehyde dehydrogenase 2 and thyrotropin receptor in patients with Graves' ophthalmopathy. [PDF]

Indian J Ophthalmol
Lin CC, Chiu LW, Lee PY, Chen KJ, Cheng KC.   +4 more
europepmc   +1 more source

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Aldehyde Inhibitors of Aldehyde Dehydrogenases

1999
Aldehyde dehydrogenases catalyze aldehyde dehydrogenation as well as ester hydrolysis. Nitrate esters e.g. isosorbide nitrates and nitroglycerin inhibit the enzyme. Mechanism of inhibition which involves aldehyde dehydrogenase catalyzed formation of a reactive species (Mukerjee and Pietruszko, 1994), which inactivates the enzyme via covalent bond ...
R, Pietruszko, D P, Abriola, G, Izaguirre, A, Kikonyogo, M, Dryjanski, W, Ambroziak   +5 more
openaire   +2 more sources

Yeast aldehyde dehydrogenase

Archives of Biochemistry and Biophysics, 1951
Summary o 1. A soluble enzyme has been isolated from baker's yeast which catalyzes the reduction of pyridine nucleotides by several aldehydes. With acetaldehyde, the most rapidly utilized substrate, the oxidative product is acetic acid. A reverse reaction was not demonstrated. 2.
openaire   +2 more sources