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Metabolism of Cyclophosphamide by Aldehyde Dehydrogenases
1995Cyclophosphamide (Endoxan) and other oxazaphosphorines such as 4-hydroperoxy-cyclophosphamide, ifosfamide, and mafosfamide are widely used as antineoplastic drugs (Sladek, 1988; Lindahl, 1992). The cytotoxic effect is caused by alkylation reaction of these drugs with DNA and proteins inhibiting the cell proliferation.
D P, Agarwal +3 more
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Metabolic Role of Aldehyde Dehydrogenase
1993Aldehyde dehydrogenase (EC 1.2.1.3), an enzyme with a broad substrate specificity and low Km values for short chain aliphatic aldehydes utilizes NAD as coenzyme, is universally distributed in mammalian livers and also at lower concentrations in other organs. The enzyme is a homotetramer of MW of ca. 220,000 (see review by Pietruszko, 1989).
W, Ambroziak, R, Pietruszko
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Alcohol dehydrogenases and aldehyde dehydrogenases
Biochemical Society Transactions, 1988HANS JÖRNVALL +6 more
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Aldehyde Dehydrogenases — The 1992 Perspective
1993The past decade has been an exciting one for researchers studying the family of enzymes collectively known as the aldehyde dehydrogenases. Ten years ago, if aldehyde dehydrogenases were even known to scientists outside the small group who actively studied the enzyme, it was for their role in acetaldehyde oxidation.
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ALDEHYDE DEHYDROGENASES AND ALCOHOLISM
Alcoholism: Clinical and Experimental Research, 1990openaire +2 more sources
Non-P450 Aldehyde Oxidizing Enzymes: The Aldehyde Dehydrogenase Superfamily
Expert Opinion on Drug Metabolism and Toxicology, 2008Vasilis Vasiliou, Chad Brocker
exaly