Results 11 to 20 of about 71,052 (154)

Synthesis and Activity-Based Protein Profiling Identifies Aldo-Keto Reductase 1C3 as Target Protein of Myxoglucamides. [PDF]

Angew Chem Int Ed Engl
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Siemon T, Mishra VK, Zhao M, Büssow K, Popoff A, Fu C, Müller R, Jänsch L, Blankenfeldt W, Brönstrup M.   +9 more
europepmc   +2 more sources

Proteomic Analysis of 2,4,6-Trinitrotoluene Degrading Yeast Yarrowia lipolytica

Frontiers in Microbiology, 2017
2,4,6-trinitrotoluene (TNT) is a common component of many explosives. The overproduction and extensive usage of TNT significantly contaminates the environment.
Irina V. Khilyas, Guenter Lochnit, Olga N. Ilinskaya   +2 more
doaj   +1 more source

Tungstoenzymes: Occurrence, Catalytic Diversity and Cofactor Synthesis

Inorganics, 2020
Tungsten is the heaviest element used in biological systems. It occurs in the active sites of several bacterial or archaeal enzymes and is ligated to an organic cofactor (metallopterin or metal binding pterin; MPT) which is referred to as tungsten ...
Carola S. Seelmann, Max Willistein, Johann Heider, Matthias Boll   +3 more
doaj   +1 more source

A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire [PDF]

, 2023
Aldehyde oxidoreductases (AORs) are tungsten enzymes catalyzing the oxidation of many different aldehydes to the corresponding carboxylic acids. In contrast to other known AORs, the enzyme from the denitrifying betaproteobacterium Aromatoleum aromaticum (
Winiarska, Agnieszka, Fidel Ramírez-Amador, Hege, Dominik, Winiarska, A., Prinz, Simone, Dominik Hege, Hege, D., Szaleniec, Maciej, Agnieszka Winiarska, Gemmecker, Y., Georg Hochberg, Prinz, S., Szaleniec, M., Johann Heider, Ramírez-Amador, Fidel, Hochberg, G., Heider, J., Gemmecker, Yvonne, Schuller, Jan Michael, Prinz, S. ; https://orcid.org/, Simone Prinz, Yvonne Gemmecker, Maciej Szaleniec, Heider, Johann, Jan Michael Schuller, Ramírez-Amador, F., Schuller, J., Hochberg, Georg, Hochberg, G. ; https://orcid.org/   +28 more
core   +1 more source

Aldehyde dehydrogenase 1A1 and gelsolin identified as novel invasion-modulating factors in conditioned medium of pancreatic cancer cells [PDF]

, 2008
Conditioned medium (CM) from clonal sub-populations of the pancreatic cancer cell line, MiaPaCa-2 with differing invasive abilities, were examined for their effect on in vitro invasion.
Naomi Walsh, Martin Clynes, Clynes, Martin, O'Donovan, Norma, Michael Henry, Walsh, Naomi, Dowling, Paul, Paula Meleady, Meleady, Paula, Norma O'Donovan, O\u27Donovan, Norma, Henry, Michael, Paul Dowling   +12 more
core   +2 more sources

Identification of crucial amino acids in mouse aldehyde oxidase 3 that determine substrate specificity.

PLoS ONE, 2013
In order to elucidate factors that determine substrate specificity and activity of mammalian molybdo-flavoproteins we performed site directed mutagenesis of mouse aldehyde oxidase 3 (mAOX3).
Martin Mahro, Natércia F Brás, Nuno M F S A Cerqueira, Christian Teutloff, Catarina Coelho, Maria João Romão, Silke Leimkühler   +6 more
doaj   +1 more source

Highly stable and reusable immobilized formate dehydrogenases: Promising biocatalysts for in situ regeneration of NADH

Beilstein Journal of Organic Chemistry, 2016
This study aimed to prepare robust immobilized formate dehydrogenase (FDH) preparations which can be used as effective biocatalysts along with functional oxidoreductases, in which in situ regeneration of NADH is required.
Barış Binay, Dilek Alagöz, Deniz Yildirim, Ayhan Çelik, S. Seyhan Tükel   +4 more
doaj   +1 more source

How Does Fusarium oxysporum Sense and Respond to Nicotinaldehyde, an Inhibitor of the NAD+ Salvage Biosynthesis Pathway?

Frontiers in Microbiology, 2019
Plant pathogenic fungi are a major threat to food security and impose a severe economic burden, thus there is a continuous need to develop new strategies to manage them.
Gautam Anand, Daniel Waiger, Nuria Vital, Jacob Maman, Li Jun Ma, Shay Covo   +5 more
doaj   +1 more source

Electron microscopic analysis and structural characterization of novel NADP(H)-containing methanol:N,N'-dimethyl-4-nitrosoaniline oxidoreductases from the gram-positive methylotrophic bacteria Amycolatopsis methanolica and Mycobacterium gastri MB19 [PDF]

, 1993
The quaternary protein structure of two methanol:N,N'-dimethyl-4-nitrosoaniline (NDMA) oxidoreductases purified from Amycolatopsis methanolica and Mycobacterium gastri MB19 was analyzed by electron microscopy and image processing.
Bystrykh, Leonid V, Bruggen, Ernst F.J. van, Duine, Johannis A., Dijkhuizen, Lubbert, Dijkhuizen, Lubbert; id_orcid, Van Beeumen, Jozef, Beeumen, Jozef van, Arfman, Nico, Bystrykh, Leonid V., van Bruggen, Ernst FJ, Govorukhina, Natalya I, Samyn, Bart, Duine, Johannis A, Govorukhina, Natalya I., Vonck, Janet   +14 more
core   +4 more sources

Studying Electron Transfer Pathways in Oxidoreductases [PDF]

, 2020
Oxidoreductases containing transition metal ions are widespread in nature and are essential for living organisms. The copper-containing nitrite reductase (NirK) and the molybdenum-containing aldehyde oxidoreductase (Aor) are typical examples of ...
González, Pablo Javier, Brondino, Carlos Dante, Ferroni, Felix Martín, Rivas, Maria Gabriela, Rizzi, Alberto Claudio   +4 more
core