Results 31 to 40 of about 71,052 (154)

Thiamine Diphosphate‐Dependent Biocatalysis in the 21st Century

Chemistry – A European Journal, EarlyView.
This account summarizes the major discoveries and recent advances, highlighting the biocatalytic abilities, mechanistic studies, and feature‐based classification that are shaping emerging perspectives on thiamine diphosphate (ThDP)‐dependent catalysis.
Lucrezia Lanza, Daniela Bjarnesen, Michael Müller   +2 more
wiley   +1 more source

Chiral Aldehyde Catalysis Enables Direct Asymmetric Substitution Reaction of N-Unprotected Amino Acids with Halohydrocarbons [PDF]

, 2023
The direct catalytic hydrocarbylation of readily available amino acids with halohydrocarbons is one of the most straightforward methods leading to disubstituted non-proteinogenic amino acid compounds.
Rong-Xing, He, Chao-Xing, Li, Wei, Wen, Zhu-Lian, Wu, Xin, Jiang, Tian, Cai, Jian-Hua, Liu, Fang, Zhu, Hao-Ran, Shen, Yao, Lin, Qi-Xiang, Guo, Yao Lin, Fang Zhu, Zhu-Lian Wu, Qi-Xiang Guo, Jian-Hua Liu, Hao-Ran Shen, Chao-Xing Li, Wei Wen, Xin Jiang, Rong-Xing He, Tian Cai   +21 more
core   +2 more sources

Silicon differentially protects PSII and PSI photochemistry and preserves fatty acid metabolism in salt‐stressed Sorghum bicolor (L.)

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Silicon (Si) has been demonstrated to be an important element to enhance crop tolerance against salinity. Nevertheless, mechanisms underlying Si's mitigation of salt stress remains insufficiently explored and understood. This study aims to provide new insights into Si's impact on salt‐stressed Sorghum bicolor (L.) supplied or not ...
Farah Bounaouara, Rabaa Hidri, Mohammed Falouti, Salma Nait Mohamed, Mokded Rabhi, Ahmed Hichem Hamzaoui, Issam Nouairi, Nabil Ben Youssef, Cécile Cabassa, Arnould Savouré, Chedly Abdelly, Inès Slama, Walid Zorrig   +12 more
wiley   +1 more source

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

Covalent immobilization of Candida methylica formate dehydrogenase on short spacer arm aldehyde group containing supports

, 2016
Formate dehydrogenases are promising enzymes for in situ regeneration of reduced form of nicotinamide adenine dinucleotide. However, the low operational stability of free form of formate dehydrogenases restricts their industrial uses.
Tükel S.S., Binay B., Alagöz D., YIldIrIm D., Çelik A.   +4 more
core   +1 more source

Plant‐Derived Natural Product Nanodelivery System in Cancer Therapy

Phytotherapy Research, EarlyView.
This review comprehensively summarizes the recent progress and emerging concepts in nanotechnology‐based delivery systems for plant‐derived natural products, with a particular focus on their application in precision cancer therapy. ABSTRACT Plant‐derived natural products have emerged as important sources of anticancer agents because of their diverse ...
Changqi Shi, LuLu Zhang, Lan Yan, Qi Geng, Li Li, Xiaojuan He, Ning Zhao, Yong Tan, Xiaomeng Zhang, Cheng Lu   +9 more
wiley   +1 more source

Exploring Oxidoreductases from Extremophiles for Biosynthesis in a Non-Aqueous System

, 2023
Organic solvent tolerant oxidoreductases are significant for both scientific research and biomanufacturing. However, it is really challenging to obtain oxidoreductases due to the shortages of natural resources and the difficulty to obtained it via ...
Hangbin Lei, Shizhen Wang, Zhehui Ji, Lei, Hangbin, Wang, Shizhen, Ji, Zhehui   +5 more
core   +1 more source

Notoginsenoside R2 Antagonizes Renal Interstitial Fibrosis by Regulating Fatty Acid Oxidation via the CASP2/ALDH3A1 Axis

Phytotherapy Research, EarlyView.
Proposed mechanism by which notoginsenoside R2 (NGR2) attenuates renal interstitial fibrosis. In injured renal tubular epithelial cells, CASP2 downregulation and enhanced ubiquitin‐dependent degradation of ALDH3A1 disrupt mitochondria‐associated endoplasmic reticulum membranes (MAMs) and impair fatty acid oxidation (FAO), leading to lipid accumulation ...
Guanting Chen, Tao Li, Zhenzhen Wang, Hao Zhao, Xiaoxia Xun, Yijiao Wang, Shiyuan Jiang, Qing Zhang, Weiwei Sun, Kang Yang, Yaoxian Wang   +10 more
wiley   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Aldonolactone oxidoreductases

, 2014
Vitamin C is a widely used vitamin. Here we review the occurrence and properties of aldonolactone oxidoreductases, an important group of flavoenzymes responsible for the ultimate production of vitamin C and its analogs in animals, plants, and single-cell
Willem J. H. van Berkel, Leferink, N.G.H., Nicole G. H. Leferink, Leferink, Nicole G.H., van Berkel, Willem J.H., Berkel, W.J.H., van   +5 more
core   +1 more source