Results 31 to 40 of about 6,425 (174)

Proteomic analysis of Clostridium thermocellum core metabolism: relative protein expression profiles and growth phase-dependent changes in protein expression

BMC Microbiology, 2012
Background Clostridium thermocellum produces H2 and ethanol, as well as CO2, acetate, formate, and lactate, directly from cellulosic biomass. It is therefore an attractive model for biofuel production via consolidated bioprocessing.
Rydzak Thomas, McQueen Peter D, Krokhin Oleg V, Spicer Vic, Ezzati Peyman, Dwivedi Ravi C, Shamshurin Dmitry, Levin David B, Wilkins John A, Sparling Richard   +9 more
doaj   +1 more source

Molybdenum Incorporation in Tungsten Aldehyde Oxidoreductase Enzymes from Pyrococcus furiosus [PDF]

Journal of Bacteriology, 2010
ABSTRACT The hyperthermophilic archaeon Pyrococcus furiosus expresses five aldehyde oxidoreductase (AOR) enzymes, all containing a tungsto-bispterin cofactor. The growth of this organism is fully dependent on the presence of tungsten in the growth medium.
Sevcenco, A.M. (author), Bevers, L.E. (author), Pinkse, M.W.H. (author), Krijger, G.C. (author), Wolterbeek, H.T. (author), Verhaert, P.D.E.M. (author), Hagen, W.R. (author), Hagedoorn, P.L. (author)   +7 more
openaire   +4 more sources

Fig. 59 in The scope of flavin-dependent reactions and processes in the model plant Arabidopsis thaliana [PDF]

, 2021
Fig. 59. Putative reaction catalyzed by HTH (HOTHEAD). Shown are the successive oxidations of the ω-hydroxyl group to the aldehyde and eventually, to the carboxy-group, leading to an α,ω-dicarboxylic acid.
Winkler, Andreas, Toplak, Marina, Jammer, Alexandra, Strandback, Emilia, Macheroux, Peter, Eggers, Reinmar, Kerschbaumer, Bianca, Lahham, Majd, Jha, Shalinee, Wallner, Silvia   +9 more
core   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

Tungsten‐containing aldehyde oxidoreductase of Eubacterium acidaminophilum [PDF]

European Journal of Biochemistry, 2003
Aldehyde oxidoreductase of Eubacterium acidaminophilum was purified to homogeneity under strict anaerobic conditions using a four‐step procedure. The purified enzyme was present as a monomer with an apparent molecular mass of 67 kDa and contained 6.0 ± 0.1 iron, 1.1 ± 0.2 tungsten, about 0.6 mol pterin cofactor and zinc, but no molybdenum.
David Rauh, Andrea Graentzdoerffer, Katrin Granderath, Jan R. Andreesen, Andreas Pich   +4 more
openaire   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Classification of tungsten-containing oxidoreductases provides insights into their biochemical and physiological diversity

Frontiers in Microbiology
Tungsten-containing oxidoreductases (WORs) are a diverse family of enzymes with over 4,000 known members that can be subdivided into 92 clades based on the phylogeny of the large pyranopterin cofactor-containing large subunit (WorL).
Saisuki Putumbaka, Michael P. Thorgersen, Gerrit J. Schut, Farris L. Poole, Claire E. Barrow, Jennifer B. Glass, Michael W. W. Adams   +6 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Protein hydrolysates in cell culture: Toward multi‐omics characterization

Biotechnology Progress, EarlyView.
While protein hydrolysates are widely used in cell culture applications, they remain undefined and variable products. Multi‐omic characterization evaluating composition and function can transition hydrolysates toward semi‐defined media components.
Michelle Combe, Brandon M. Wrage, Angel Varela‐Rohena, Stanislav Sokolenko   +3 more
wiley   +1 more source

Combining phenotypic, physiological, and multi‐omics studies to provide new insights on the role of 2,4‐epibrassinolide in regulation of seed shattering in Elymus sibiricus L.

Grassland Research, EarlyView.
Abstract Background Seed shattering limits the production of Elymus sibiricus L., and application of exogenous brassinosteroid significantly alleviates plant organ abscission. Methods To explore the potential regulatory network of brassinosteroid on seed shattering, the abscission zone of E. sibiricus cv. Lanyu No.
Huanhuan Lu, Yiyang Wan, Liuban Tang, Yongsen Qiu, Yancui Zhao, Yuying Zheng, Wengang Xie   +6 more
wiley   +1 more source