Results 51 to 60 of about 71,052 (154)

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Discovery of a First‐in‐Class Dual‐Function TLX Activator by Microscale Library Synthesis and Direct‐to‐Biology Screening

Angewandte Chemie Novit, Volume 2, Issue 4, December 2026.
The transcription factor tailless (TLX) is an orphan nuclear receptor thought to maintain neural and retinal stem cell populations in a proliferating state to enable regeneration. Ligands to study TLX modulation were lacking. We developed a potent TLX agonist capable of activating TLX's transcriptional repressor and activator properties in an evolution‐
Tanja Stiller, Romy Busch, Giuseppe Faudone, Felia C. Haffelder, Jan Vietor, Arthur Kardanov, Úrsula López‐García, Arne Hackspacher, Georg Höfner, Vasily Morozov, Susanne F. Koch, Julian A. Marschner, Daniel Merk   +12 more
wiley   +1 more source

A Structure-Based Approach for Detection of Thiol Oxidoreductases and Their Catalytic Redox-Active Cysteine Residues [PDF]

, 2009
Cysteine (Cys) residues often play critical roles in proteins, for example, in the formation of structural disulfide bonds, metal binding, targeting proteins to the membranes, and various catalytic functions.
Vadim N Gladyshev, Stefano M Marino, Marino, Stefano M., Marino Stefano M., Gladyshev Vadim N., Gladyshev, Vadim N.   +5 more
core   +2 more sources

One Hundred Years of Sulfido Ligand in the Molybdenum Cofactor: New Perspectives

ChemBioChem, Volume 27, Issue 19, 14 October 2026.
The terminal sulfido ligand in mononuclear molybdoenzymes has been appreciated for almost 125 years, with the characterization of Schardinger's enzyme in cow's milk, now known to be xanthine oxidase, that was isolated in 1902 in Vienna, Austria. The ligand is found in molybdoenzymes identified across all kingdoms of life.
Silke Leimkühler, Benjamin R. Duffus, Carola Schulzke   +2 more
wiley   +1 more source

Tetra-N-confused Cyclohexapyrrole:  The Unusual Product Formed by Condensation of 3,3‘-Dipyrromethane with Tripyrrin-aldehyde

, 2016
Novel tetra-N-confused cyclohexapyrrole is synthesized for the first time via condensation of tripyrrinone-aldehyde with bis(2,4-dimethylpyrrole-3-yl)methane in the presence of p-toluenesulfonic acid monohydrate.
Yi Zhang (9093), Qingqi Chen (49519), Zheming Wang (63940), Jin Shi Ma (2426800), Genpei Li (3031374), Chunhua Yan (392686)   +5 more
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, Volume 16, Issue 10, Page 1911-1924, October 2026.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

ALDH2 mediates 5-nitrofuran activity in multiple species [PDF]

, 2012
Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of pro-drugs widely used to treat bacterial and trypanosome infections, but despite relative ...
Spitzer, Michaela, Brear, Paul, Johnson, Stephen L, Patton, E Elizabeth, Zeng, Zhiqiang, Patton, Elizabeth, Mitchell, Amy, Ishizaki, Hironori, Taylor, Kerrie L, Smith, Terry K., Westwood, Nicholas J, Patton, E Elizabeth; id_orcid, Marie, K.L.; id_orcid, McNeil, Ewan, Temperley, Nicholas, Tyers, Mike, Melton, David W, Zhou, Linna, Temperley, Nicholas D, Gautier, Philippe, Taylor, Kerrie, Narayan, Vikram, Melton, David, Westwood, Nicholas James, Smith, Terry K, Johnson, Stephen, McNeil, Ewan M, Westwood, Nicholas James; id_orcid, Smith, Terry K; id_orcid, McNeil, Ewan M., Johnson, Stephen L., Temperley, Nicholas D., Patton, E. Elizabeth, Melton, David W., Westwood, Nicholas J.   +34 more
core   +1 more source

Polyphenol‐Inspired Materials for Agricultural Applications

Advanced Materials, Volume 38, Issue 59, 22 October 2026.
This review outlines the use of polyphenol‐inspired materials for sustainable agriculture, highlighting their molecular design, interfacial assembly, structure–property relationships, and prospects toward precision agriculture, climate resilience, ecosystem protection, and circular bioeconomy strategies.
Haofu Liu, Omid Mazaheri, Zhixing Lin, Tianzheng Wang, Jingqu Chen, Yuang Gu, Xia Liang, Deli Chen, Frank Caruso   +8 more
wiley   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

UHPLC/MS‐MS Profiling, Antioxidant and Antimicrobial Properties of Atriplex halimus L. and Marrubium deserti De Noé Extracts: In Vitro and In Silico [PDF]

Chem Biodivers
This study investigates the phytochemical profile and biological potential of Atriplex halimus L. and Marrubium deserti De Noé extracts. Polyphenolic constituents are identified using UHPLC‐MS/MS analysis, complemented by TPC and TFC evaluations. Antioxidant activities are determined via DPPH, ABTS, and FRAP assays, while antimicrobial efficacy is ...
Siad N, Hamia C, Djeridane A, Benalia M, Mahfoudi R, Bouakkaz H, Yilmaz M, Cakir O, Tarhan A, Yousfi M.   +9 more
europepmc   +2 more sources